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Synthesis and Characterization of a Novel pH-Sensitive Aluminum Crosslinked Carboxymethyl Tragacanth Beads for Extended and Enteric Drug Delivery

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Abstract

Carboxymethyl tragacanth (CM-TG) with a DS of 1.2 was synthesized and characterized for drug delivery using diclofenac sodium as a model drug. The mixture of CM-TG and drug was ionically crosslinked using aluminum chloride to form drug-loaded beads. The concentrations of 10 and 20% w/w solution of CM-TG were found to produce beads with acceptable qualities. The beads exhibited pH-dependent swelling. The highest swelling was observed at pH 6.8 which evidences the possibility to release the drug in the colon. FT-IR and TGA confirmed carboxymethylation of tragacanth and the absence of drug-polymer interaction. The diclofenac sodium entrapment efficiency was 30–35% while the loading varies from 4.5 to 18% w/w based upon the drug-polymer ratio. The beads could extend the drug release up to 180 min at pH 6.8. The pH-responsive CM-TG hydrogel beads are biocompatible and could be exploited as a new excipient in developing enteric release formulations.

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Acknowledgements

The authors are thankful to the School of Science, Monash University Malaysia for providing the higher degree research financial assistance to the Ph.D. students.

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Authors and Affiliations

  1. School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500, Subang Jaya, Selangor Darul Ehsan, Malaysia

    Anand Kumar Veeramachineni, Ragul Paramasivam & Janarthanan Pushpamalar

  2. School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500, Subang Jaya, Selangor Darul Ehsan, Malaysia

    Thenapakiam Sathasivam

  3. Monash-Industry Palm Oil Education and Research Platform (MIPO), Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia

    Thenapakiam Sathasivam & Janarthanan Pushpamalar

  4. Department of Pharmacy, Fatima College of Health Sciences, Al Maqam, Al Ain, United Arab Emirates

    Saravanan Muniyandy

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  1. Anand Kumar Veeramachineni
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  2. Thenapakiam Sathasivam
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  3. Ragul Paramasivam
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  4. Saravanan Muniyandy
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  5. Janarthanan Pushpamalar
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Correspondence to Janarthanan Pushpamalar.

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Veeramachineni, A.K., Sathasivam, T., Paramasivam, R. et al. Synthesis and Characterization of a Novel pH-Sensitive Aluminum Crosslinked Carboxymethyl Tragacanth Beads for Extended and Enteric Drug Delivery. J Polym Environ 27, 1516–1528 (2019). https://doi.org/10.1007/s10924-019-01448-5

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  • DOI: https://doi.org/10.1007/s10924-019-01448-5

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