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Vegetable Oil Based Polyurethane Containing 1,2,3-Triazolium Functional Groups as Antimicrobial Wound Dressing

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Abstract

Preparation of antimicrobial polyurethane wound dressing membranes from a mixture of castor oil and a novel soybean oil-based polyol containing 1,2,3-triazolium rings (QTSBO) was described in this research. QTSBO was prepared through N-alkylation of 1,2,3-triazole functional soybean oil (TSBO) with methyl iodide, and TSBO was synthesized from an azidated soybean oil and propargyl alcohol through click reaction. The excellent tensile strength of these dressings under dry state and minimum deterioration of this property at fully hydrated state guaranteed the mechanical protection of wounds during the entire period of the healing process. The measured quantities of equilibrium water absorption and water vapor transmission rate for the optimized dressings confirmed the applicability of the selected formulations for the preservation of proper moist environment over low exuding wounds. The cyto-compatibility of dressings was verified by the excellent ability of the dressings to support the growth and proliferation of dermal fibroblasts. Due to the presence of 1,2,3-triazolium rings the dressing showed efficient antimicrobial activity against different bacterial and fungal stains. Therefore, these dressing could promote wound healing by preserving moist and hygienic environment over the wound bed.

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Authors and Affiliations

  1. Iran Polymer and Petrochemical Institute, P.O. Box: 14945/115, Tehran, Iran

    Hoshyar Gholami, Hamid Yeganeh & Marziyeh Sorayya

  2. Biomedical Engineering Department, Faculty of Engineering, Islamic Azad University, Central Tehran Branch, Tehran, Iran

    Saeed Beigi Burujeny

  3. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran

    Elias Shams

Authors
  1. Hoshyar Gholami
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  2. Hamid Yeganeh
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  3. Saeed Beigi Burujeny
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  4. Marziyeh Sorayya
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  5. Elias Shams
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Correspondence to Hamid Yeganeh.

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Gholami, H., Yeganeh, H., Burujeny, S.B. et al. Vegetable Oil Based Polyurethane Containing 1,2,3-Triazolium Functional Groups as Antimicrobial Wound Dressing. J Polym Environ 26, 462–473 (2018). https://doi.org/10.1007/s10924-017-0964-y

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  • DOI: https://doi.org/10.1007/s10924-017-0964-y

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