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Solvent-Free Synthesis of 1, 4 Dihydropyridines Derivatives via Hantzsch Reaction Employing MgFe2O4 MNPs: An Efficient and Recyclable Heterogeneous Catalyst

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Abstract

Pristine magnesium spinel ferrite nanoparticles (MgFe2O4, MNPs) were fabricated via sol–gel auto combustion and elucidated by XRD, SEM, EDAX, TEM, FTIR, BET and VSM for structural and physical characteristics. Fabricated MgFe2O4 MNPs found to be an efficient, robust and magnetically separable reusable heterogeneous catalyst for one pot three component solvent free synthesis of biologically important 1,4-dihydropyridines (1, 4 DHP’s) via Hantzsch condensation reaction. This convention was effectively appropriate to an extensive variety physically distinct aryl-aldehydes with ethyl acetoacetate and ammonium acetate to manage the required 1,4-dihydropyridines (1, 4 DHP’s) derivatives. The structural investigations approved the sustainability and reusability of the MgFe2O4, MNPs towards current organic reactions. The novelties of this protocol are operational cleanness, short reaction time, nontoxic, inexpensive and magnetically separable heterogeneous catalyst may perhaps easily be recycled deprived of remarkable decline in catalytic performance.

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Acknowledgements

The authors are very much indebted to Punyashlok Ahilyadevi Holkar Solapur University for XRD, Materials Research Centre, Malaviya National Institute of Technology (MNIT), Jaipur for TEM and Zeta potential characterization, and Sophisticated Analytical Instrument Facility (SAIF), Panjab University, Chandigarh for NMR and HRMS measurements.

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Authors and Affiliations

  1. Department of Chemistry, Government Institute of Forensic Science, Aurangabad, MS, 431004, India

    Ravikumar M. Borade

  2. Department of Applied Science, Government Polytechnic, Aurangabad, MS, 431004, India

    Swati B. Kale

  3. Department of Physics, Shri Shivaji Science College, Amravati, MS, 444603, India

    Pankaj P. Khirade

  4. Department of Basic and Applied Sciences, MGM University, Aurangabad, MS, 431003, India

    K. M. Jadhav

  5. Department of Chemistry, Shivchhatrapati College, Aurangabad, MS, 431003, India

    Rajendra P. Pawar

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Contributions

RMB: Formal analysis, investigation, methodology, data curation, visualization, writing original draft. SBK: investigation, methodology, PPK: formal analysis, visualization, writing—review and editing. KMJ: conceptualization, supervision, RPP: validation, supervision.

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Borade, R.M., Kale, S.B., Khirade, P.P. et al. Solvent-Free Synthesis of 1, 4 Dihydropyridines Derivatives via Hantzsch Reaction Employing MgFe2O4 MNPs: An Efficient and Recyclable Heterogeneous Catalyst. J Inorg Organomet Polym 34, 1104–1120 (2024). https://doi.org/10.1007/s10904-023-02858-8

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