Abstract
As a biocompatible porous material, bio-MOF is a very promising material as a carrier for hydrophobic drugs, including curcumin. However, the stability of bio-MOF against water and humidity still needs to be improved; therefore, surface modifications are required. This study aims to modify the MIL-100(Fe)-based bio-MOF through core–shell architecture by employing mesoporous silica nanoparticles (MSNs or SiO2) for improving the stability and performance of MIL-100(Fe) to provide a slow-release feature of curcumin. The composites were synthesized via sonochemistry-assisted or mechanochemistry-assisted green protocol to form core–shell structure of MIL-100(Fe)@SiO2 (Composite-1) or SiO2@MIL-100(Fe) (Composite-2). Structural, textural, and morphological analyses, including XRD, FTIR, SEM, TEM, and N2 adsorption–desorption, are discussed in this study to evaluate the composite formation. BET surface area of the MIL-100(Fe) decreased from 1197.45 m2/g to 565.63 and 823.70 m2/g after forming composite-1 and composite-2 with SiO2. The loading capacity, however, just increased slightly up to 97.89% after the modification. The presence of SiO2 as shell (composite-1) protects the MIL-100(Fe) from degradation under the acidic condition at pH 5.8 and can maintain the slow-release of curcumin. In contrast, the presence of SiO2 as core (composite-2) induces the sustained release due to faster degradation of MIL-100(Fe) in acidic condition. Both composites serve as a model for either sustained release or delayed release drug delivery systems.
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W. Liu, J. Yuan, H. Zhu, X. Zhang, L. Li, X. Liao, Z. Wen, Y. Chen, H. Feng, J. Lin, Neurosci. Lett. 620, 74 (2016)
S. Abrahams, W.L. Haylett, G. Johnson, J.A. Carr, S. Bardien, Neuroscience 406, 1 (2019)
R. Jin, Y. Xia, Q. Chen, W. Li, D. Chen, H. Ye, C. Zhao, X. Du, D. Shi, J. Wu, G. Liang, Drug Des. Devel. Ther. 10, 979 (2016)
O. Naksuriya, S. Okonogi, R.M. Schiffelers, W.E. Hennink, Biomaterials 35, 3365 (2014)
S. Taverna, S. Fontana, F. Monteleone, M. Pucci, L. Saieva, V. De Caro, V.G. Cardinale, M. Giallombardo, E. Vicario, C. Rolfo, G. De Leo, R. Alessandro, Oncotarget 7, 30420 (2016)
S. Wanninger, V. Lorenz, A. Subhan, F.T. Edelmann, Chem. Soc. Rev. 44, 4986 (2015)
W. Park, A.R.M. Ruhul Amin, Z.G. Chen, D.M. Shin, Cancer Prev. Res. 6, 387 (2013)
X.M. Zhu, J. Yuan, K.C.F. Leung, S.F. Lee, K.W.Y. Sham, C.H.K. Cheng, D.W.T. Au, G.J. Teng, A.T. Ahuja, Y.X.J. Wang, Nanoscale 4, 5744 (2012)
S. Bisht, G. Feldmann, S. Soni, R. Ravi, C. Karikar, A. Maitra, A. Maitra, J. Nanobiotechnol. 5, 1 (2007)
Z. Wang, M.H.M. Leung, T.W. Kee, D.S. English, Langmuir 26, 5520 (2010)
D. Psimadas, P. Georgoulias, V. Valotassiou, G. Loudos, J. Pharm. Sci. 101, 2271 (2012)
M.X. Wu, Y.W. Yang, Adv. Mater. 29, 1 (2017)
M.A. Adahoun, M.A.H. Al-Akhras, M.S. Jaafar, M. Bououdina, Artif. Cells Nanomed. Biotechnol. 45, 98 (2017)
Y. Zhang, L. Wang, L. Liu, L. Lin, F. Liu, Z. Xie, H. Tian, X. Chen, A.C.S. Appl, Mater. Interfaces 10, 41035 (2018)
A. Maleki, V. Eskandarpour, J. Rahimi, N. Hamidi, Carbohydr. Polym. 208, 251 (2019)
J. Ren, N.M. Musyoka, H.W. Langmi, M. Mathe, S. Liao, Int. J. Hydrogen Energy 42, 289 (2017)
I. Ahmed, S.H. Jhung, Biochem. Pharmacol. 17, 136 (2014)
L. Shaozhou, H. Fengwei, Nanoscale 7, 7482 (2015)
R.A. Raj Kumar, K. Mondal, P.K. Panda, A. Kaushik, Y.K.M. Rajeev Ahuja, H.G. Rubahn, J. Mater. Chem. B 8, 8992 (2020)
P. T., C. D. J. Ratchapol, Biomaterials 10, 2756 (2020)
Y.Z. Huai-Xin, Z. Quan, S. Shao-Kai, Y. Chunshui, Z. Xuejun, Rui-Jun Li, and Yan-Fu. Chem. Sci. 8, 5294 (2016)
D. Wang, J. Zhou, R. Shi, H. Wu, R. Chen, B. Duan, G. Xia, P. Xu, H. Wang, S. Zhou, C. Wang, H. Wang, Z. Guo, 7 (2017)
J.W.M. Osterrieth, D. Wright, H. Noh, C. Kung, D. Vulpe, A. Li, J.E. Park, R.P. Van Duyne, P.Z. Moghadam, J.J. Baumberg, O.K. Farha, D. Fairen-jimenez, J. Am. Chem. Soc. 141, 3893 (2019)
B. Wu, J. Fu, Y. Zhou, S. Luo, and Y. Zhao, Acta Pharm. Sin. B (2020)
L. Lu, M. Ma, C. Gao, H. Li, L. Li, F. Dong, and Y. Xiong, Pharmaceutics 12, (2020)
N. Ahmadi Nasab, H. Hassani Kumleh, M. Kazemzad, F. Ghavipanjeh, Iran. J. Chem. Chem. Eng. 33, 37 (2014)
S. Kim, M.J. Stébé, J.L. Blin, A. Pasc, J. Mater. Chem. B 2, 7910 (2014)
S. Ghosh, Mesoporous Silica-Based Nano Drug-Delivery System Synthesis, Characterization, and Applications (Elsevier Inc., 2019)
S. Zinatloo-Ajabshir, S. Mortazavi-Derazkola, M. Salavati-Niasari, J. Mol. Liq. 231, 306 (2017)
C. Adhikari, A. Mishra, D. Nayak, A. Chakraborty, J. Drug Deliv. Sci. Technol. 47, 1 (2018)
J. Ying, A. Herbst, Y.X. Xiao, H. Wei, G. Tian, Z. Li, X.Y. Yang, B.L. Su, C. Janiak, Inorg. Chem. 57, 899 (2018)
X. Jia, Z. Yang, Y. Wang, Y. Chen, H. Yuan, H. Chen, X. Xu, X. Gao, Z. Liang, Y. Sun, J.R. Li, H. Zheng, R. Cao, ChemMedChem 13, 400 (2018)
Z.Q. Li, A. Wang, C.Y. Guo, Y.F. Tai, L.G. Qiu, Dalt. Trans. 42, 13948 (2013)
H. Hosseini, H. Ahmar, A. Dehghani, A. Bagheri, A.R. Fakhari, M.M. Amini, Electrochim. Acta 88, 301 (2013)
L. Han, H. Qi, D. Zhang, G. Ye, W. Zhou, C. Hou, W. Xu, Y. Sun, New J. Chem. 41, 13504 (2017)
S. Gai, P. Yang, C. Li, W. Wang, Y. Dai, N. Niu, J. Lin, Adv. Funct. Mater. 20, 1166 (2010)
P. George, R.K. Das, P. Chowdhury, Microporous Mesoporous Mater. 281, 161 (2019)
Promega Corporation, Promega - Protocols & Applications Guide (2009)
P. Horcajada, S. Surblé, C. Serre, D.Y. Hong, Y.K. Seo, J.S. Chang, J.M. Grenèche, I. Margiolaki, G. Férey, Chem. Commun. 100, 2820 (2007)
X. Ke, N. Qin, T. Zhang, F. Ke, X. Yan, J. Inorg. Organomet. Polym. Mater. 30, 935 (2020)
N.M. Mahmoodi, J. Abdi, M. Oveisi, M. Alinia Asli, M. Vossoughi, Mater. Res. Bull. 100, 357 (2018)
S.E. Moradi, S. Dadfarnia, A.M. Haji Shabani, S. Emami, Desalin. Water Treat. 56, 709 (2015)
S.M. Shawky, A.A. Abo-alhassan, H. Lill, D. Bald, S.F. El-khamisy, E. M. Ebeid 1, 1 (2016)
A. Lajevardi, M. Hossaini, A. Badiei, M. Armaghan, J. Mol. Liq. 307, 112996 (2020)
P. Horcajada, C. Serre, M. Vallet-regí, M. Sebban, F. Taulelle, G. Førey, 6120 (2006)
C.R. Quijia, C. Lima, C. Silva, R.C. Alves, R. Frem, M. Chorilli, J. Drug Deliv. Sci. Technol. 61, 102217 (2021)
K. Fujioka, M. Pans, S. Joyal, Clin. Ther. 25, 515 (2003)
C. Guo, Haibin, Y. Shen, K. Feng, Y. Xia, X. Qu, F. Wan, Zhang, Chem. Eng. J. 403, 126432 (2021)
Z. Zou, S. Li, D. He, X. He, K. Wang, L. Li, X. Yang, H. Li, J. Mater. Chem. B 5, 2126 (2017)
L. Chen, J. Zhang, X. Zhou, S. Yang, Q. Zhang, W. Wang, Z. You, C. Peng, C. He, Acta Biomater. 86, 406 (2019)
N.D. Bikiaris, N.M. Ainali, E. Christodoulou, M. Kostoglou, T. Kehagias, E. Papasouli, E.N. Koukaras, S.G. Nanaki, Nanomaterials 10, 1 (2020)
Acknowledgements
We gratefully acknowledge PNBP Universitas Sebelas Maret in the scheme Advanced Applied Research (PUT) project number 260/UN27.22/HK.07.00/2021 for funding.
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This study was funded by PNBP Universitas Sebelas Maret in the scheme of Advanced Applied Research (PUT) under Grant Number 260/UN27.22/HK.07.00/2021.
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Conceptualization: WWL; methodology: NF, WWL; TES: formal analysis and investigation: NF, OAS; writing—original draft preparation: NF, WWL, OAS; writing—review and editing: OAS, WWL, TES, LL, FRW; funding acquisition: [WWL], …; Resources: [WWL], …; Supervision: [WWL, TES, FRW].
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Faaizatunnisa, N., Lestari, W.W., Saputra, O.A. et al. Slow-Release of Curcumin Induced by Core–Shell Mesoporous Silica Nanoparticles (MSNs) Modified MIL-100(Fe) Composite. J Inorg Organomet Polym 32, 1744–1754 (2022). https://doi.org/10.1007/s10904-022-02230-2
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DOI: https://doi.org/10.1007/s10904-022-02230-2