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NIR-Laser Triggered Drug Release from Molybdenum Disulfide Nanosheets Modified with Thermosensitive Polymer for Prostate Cancer Treatment

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Abstract

In the present study, the thermosensitive polymers were successfully grown on the surface of molybdenum disulfide nanosheets (MNs) by free radical polymerization method, then the polymer were characterized by x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and thermo gravimetric analysis (TGA). The thermosensitive polymer was prepared from allyl glycidyl ether (AGE) and N-isopropyl acrylamide (NIPAM) and then coated with methoxypolyethylene glycol (mPEG). The resultant polymer MNs@ (poly (AGE-co-NIPAM)/mPEG) was prepared as a drug carrier system for the controlled delivery of bicalutamide (BCT). Experimental factors, including pH, contact time and temperature were investigated to optimize the adsorption method. The BCT loading and release behavior of MNs @ poly (AGE-co-NIPAM)/mPEG were considered and the results indicated that up to 93% of the adsorbed BCT was released within 6 h. The investigation of adsorption kinetic was fitted well to intra-particle diffusion kinetic model with a coefficient of determination (R2) equal to 0.9996. Also, the adsorption isotherm data were better expressed by Freundlich isotherm model (R2 = 0.9969). To study the activity of the BCT/MNs @ poly (AGE-co-NIPAM)/mPEG nanocarrier under only near-infrared (NIR) light irradiation, its photothermal properties were investigated by monitoring the degradation of BCT under 808 nm NIR light irradiation. NIR laser-triggered photo thermal effects induce the shrinkage of thermo sensitive polymer which results in the control of BCT release.

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Abbreviations

MNs:

Molybdenum disulfide nanosheets

XRD:

X-ray diffraction

FTIR:

Fourier transform infrared spectroscopy

SEM:

Scanning electron microscope

TGA:

Thermo gravimetric analysis

AGE:

Allyl glycidyl ether

NIPAM:

N-isopropyl acrylamide

mPEG:

Methoxypolyethylene glycol

BCT:

Bicalutamide

NIR:

Near-infrared

NSAA:

Nonsteroidal anti-androgens

SAA:

Steroidal anti-androgen

TSP:

Thermosensitive polymers

PNIPAM:

Poly (N-isopropylacrylamide)

LCST:

Lower critical solution temperature

PEG:

Polyethylene glycol

2D:

Two dimensional

TMD:

Transition metal dichalcogenides

MoS2 :

Molybdenum disulfide

PTT:

Photo thermal therapy

MNs:

Mos2 nanosheets

EDX:

Energy dispersive X-ray

AIBN:

2,2-Azobis(2-methylpropionitrile)

DMF:

Dimethylformamide

DDW:

Distilled deionized water

D-R:

Dubinin-radushkevich

PFO:

Pseudo-first-order

PSO:

Pseudo-second-order

PZC:

Point of zero charge

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Acknowledgements

The authors would like to acknowledge Islamic Azad University (North Tehran branch) for financial support of this project.

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Authors and Affiliations

  1. Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran

    Elham Reza Soltani & Kambiz Tahvildari

  2. Department of Chemistry, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran

    Elham Moniri

  3. Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran

    Homayon Ahmad Panahi

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  1. Elham Reza Soltani
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  2. Kambiz Tahvildari
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  4. Homayon Ahmad Panahi
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Correspondence to Kambiz Tahvildari or Elham Moniri.

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Reza Soltani, E., Tahvildari, K., Moniri, E. et al. NIR-Laser Triggered Drug Release from Molybdenum Disulfide Nanosheets Modified with Thermosensitive Polymer for Prostate Cancer Treatment. J Inorg Organomet Polym 31, 4659–4669 (2021). https://doi.org/10.1007/s10904-021-02075-1

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