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Slow Released Delivery of Alendronate Using β-Cyclodextrine Modified Fe–MOF Encapsulated Porous Hydroxyapatite

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Abstract

In this study, an efficient and robust metal organic framework (MOF)-based drug delivery system comprising high potential for slow release rate is introduced. Porous Fe-MIL-88B-NH2 nano-carrier, a series of flexible designed MOF materials, was synthesized and evaluated for slow released of alendronate (Alen). The Fe-MIL-88B-NH2 nano-carrier was synthesized by direct mixing of 2-aminoterephthalic acid and ferric chloride in the presence of pluronic F127 and acetic acid. Then, the surface of the nanoparticles was modified using β-cyclodextrin in order to increase the loading of Alen. After the loading process, the nano-drug carrier was encapsulated with hydroxyapatite (HAp) as a coating agent having the bone-like structure, which assists in lowering the drug release rate by decreasing the demand dosage. HAp is in high compatibility with Alen in terms of their positive impact on body bones. In order to confirm the synthesis of the nano-carrier system, scanning electron microscope, X-ray powder diffraction, Fourier transfer infrared, thermogravimetric analysis and BET surface analysis were used. Finally controlled released of Alen over 28 days was studied, which showed good results in comparison with previous systems.

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Funding

Funding was provided by Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences (IR) and Shahrood University of Technology.

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Authors and Affiliations

  1. College of Chemistry, Shahrood University of Technology, P.O. Box 36155-316, Shahrood, Iran

    Azadeh Golmohamadpour & B. Bahramian

  2. Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran

    A. Shafiee

  3. Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Karaj, Iran

    L. Ma’mani

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  1. Azadeh Golmohamadpour
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  2. B. Bahramian
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  3. A. Shafiee
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  4. L. Ma’mani
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Correspondence to B. Bahramian or L. Ma’mani.

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Golmohamadpour, A., Bahramian, B., Shafiee, A. et al. Slow Released Delivery of Alendronate Using β-Cyclodextrine Modified Fe–MOF Encapsulated Porous Hydroxyapatite. J Inorg Organomet Polym 28, 1991–2000 (2018). https://doi.org/10.1007/s10904-018-0871-2

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  • DOI: https://doi.org/10.1007/s10904-018-0871-2

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