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Drug delivery properties of three-dimensional ordered macroporous zinc-doped hydroxyapatite

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Abstract

Porous hydroxyapatite (HA) as a drug carrier in drug delivery systems has been widely concerned. Three-dimensional ordered macroporous (3DOM) HA and 3DOM Zn-doped HA (Zn–HA) for drug delivery systems were successfully prepared to improve its amoxicillin loading and release rate. Effect of Zn doping amount on the 3DOM morphology and amoxicillin delivery properties of the HA were investigated. In the drug delivery test of amoxicillin, the prepared 3DOM Zn–HA (1 mol%) had a higher amoxicillin loading, and the drug loading of amoxicillin reached 101.4 mg g−1. The release rate of amoxicillin from the 3DOM Zn–HA (1 mol%) in the first 5 h was about 42.58%, which was significantly lower than that of pure 3DOM HA (55.37%). The 3DOM Zn–HA was expected to be a promising drug carrier for the biomedical field, though more detailed pre-clinical studies were necessary to verify these observations.

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The data in the current study are available from the corresponding author on reasonable request.

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Acknowledgments

This work was supported by National Foundation of Natural Science, China (51402179, 51272149), Scientific Research Foundation of Shaanxi University of Science & Technology (BJ14-17).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials, Shaanxi University of Science and Technology, Xi’an, 710021, China

    Li-li Wang, Xu-ri Hou, Li-na Feng, Ye-min Zhou, Xin-xin Liu & Cheng-yuan Tian

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  1. Li-li Wang
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  2. Xu-ri Hou
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The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.

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Correspondence to Li-li Wang.

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Wang, Ll., Hou, Xr., Feng, Ln. et al. Drug delivery properties of three-dimensional ordered macroporous zinc-doped hydroxyapatite. Journal of Materials Research 37, 2314–2321 (2022). https://doi.org/10.1557/s43578-022-00632-z

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  • DOI: https://doi.org/10.1557/s43578-022-00632-z

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