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Chromatographic Evaluation of Octadecyl-Bonded SiO2/SiO2-Based Stationary Phase for Reversed-Phase High Performance Liquid Chromatography

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Abstract

A new type of octadecyl-bonded SiO2/SiO2 (ODSS) core–shell monodisperse silica spheres was prepared as a high performance liquid chromatography stationary phase. The chromatographic performance was evaluated and compared with totally porous octadecyl-bonded SiO2. Various methods were used for characterization of the two column packings for reversed-phase chromatography in terms of permeability, hydrophobic selectivity, sensitivity, stability and hydrophobicity. The results showed that the ODSS-based stationary phase has enhanced permeability, good hydrophobic selectivity, high chemical stability and sensitivity. Acidic, basic and neutral aromatic compounds were separated on the two types of stationary phases. The ODSS-based stationary phase has good selectivity and gives symmetrical narrow peaks under reversed-phase conditions.

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Acknowledgments

The authors acknowledge financial support from the the National Nature Science Foundation of China (Grant: 20675085), Science and Technology Support Xinjiang Project (2010), the Science and Technology Special Project of Lanzhou (No. 2010-1-156).

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Authors and Affiliations

  1. Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, People’s Republic of China

    Xia Zhang, Zhixin Zhang, Litao Wang, Qin Liu, Xiaoli Zhang, Shuqing Dong & Liang Zhao

  2. University of Chinese Academy of Sciences, Beijing, 100039, People’s Republic of China

    Xia Zhang & Xiaoli Zhang

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  1. Xia Zhang
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  2. Zhixin Zhang
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  3. Litao Wang
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  4. Qin Liu
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  5. Xiaoli Zhang
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  6. Shuqing Dong
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  7. Liang Zhao
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Correspondence to Liang Zhao.

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Zhang, X., Zhang, Z., Wang, L. et al. Chromatographic Evaluation of Octadecyl-Bonded SiO2/SiO2-Based Stationary Phase for Reversed-Phase High Performance Liquid Chromatography. J Inorg Organomet Polym 23, 1445–1450 (2013). https://doi.org/10.1007/s10904-013-9947-1

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