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Preparation and Characterization of SiO2/SiO2 Core–Shell Microspheres as RP-HPLC Stationary Phase

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Abstract

Novel SiO2/SiO2 core–shell monodisperse silica spheres for high-performance liquid chromatography packing materials are prepared by the layer-by-layer self-assembly technique. The core–shell silica spheres consist of micrometer-sized porous silica spheres as the core and a thin mesoporous silica shell formed from multilayer nanometer-sized silica particles. In addition, a reversed-phase packing by bonding octadecyltrichlorosilane on SiO2/SiO2 particles through alkyl-modified method is prepared and characterized. The results show that the carbon content of the new reversed-phase stationary phase increases by approximately 45% compared with the uncoated octadecyl-bonded SiO2 stationary phase. Eight kinds of tested aromatic compounds are well-separated on the packing and the peaks are symmetrical, which demonstrates that the packing acts as an excellent reversed-phase chromatographic stationary phase.

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References

  1. H.M. Chen, C.H. Deng, X.M. Zhang, Angew. Chem. Int. Ed. 49, 607 (2010)

    CAS  Google Scholar 

  2. M. Omer-Mizrahi, S. Margel, J. Colloid Interface Sci. 329, 228 (2009)

    Article  CAS  Google Scholar 

  3. S. Ludtke, T. Adam, K.K. Unger, J. Chromatogr. A 786, 229 (1997)

    Article  Google Scholar 

  4. F. Li, X.T. Huang, Y. Jiang, L.Y. Liu, Z. Li, Mater. Res. Bull. 44, 437 (2009)

    Article  CAS  Google Scholar 

  5. M.L. Breen, A.D. Dinsmore, R.H. Pink, S.B. Qadri, B.R. Ratna, Langmuir 17, 903 (2001)

    Article  CAS  Google Scholar 

  6. H.J. Dun, W.Q. Zhang, Y. Wei, X.Q. Song, Y.M. Li, L.R. Chen, Anal. Chem. 76, 5016 (2004)

    Article  CAS  Google Scholar 

  7. J. Ge, X.F. Shi, Y.M. Li, L.R. Chen, Chromatographia 63, 25 (2006)

    Article  CAS  Google Scholar 

  8. J. Ge, Y.M. Li, L.R. Chen, J. Liq, Chromatogr. Rel. Technol. 29, 2329 (2006)

    Article  CAS  Google Scholar 

  9. J. Ge, W. Zhou, L. Zhao, Y.P. Shi, Anal. Lett. 40, 2515 (2007)

    Article  CAS  Google Scholar 

  10. J. Ge, L. Zhao, Y.-P. Shi, J. Liq, Chromatogr. Rel. Technol. 31, 151 (2008)

    Article  CAS  Google Scholar 

  11. J. Ge, L. Zhao, Y.P. Shi, Chin. J. Chem. 26, 139 (2008)

    Article  CAS  Google Scholar 

  12. J. Ge, L. Zhao, L.R. Chen, Y.P. Shi, J. Chromatogr. Sci. 48, 29 (2010)

    CAS  Google Scholar 

Download references

Acknowledgment

The authors acknowledge financial support to the National Nature Science Foundation of China (Grant: 20675085), Science and Technology Support Xinjiang Project (2010), the Science and Technology Special Project of Lanzhou (No.2010-1-156).

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Authors and Affiliations

  1. Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, People’s Republic of China

    Q. Liu, L.-T. Wang, S.-Q. Dong, Zh.-X. Zhang & L. Zhao

  2. Graduate University of the Chinese Academy of Sciences, Beijing, 100039, People’s Republic of China

    Q. Liu & Zh.-X. Zhang

Authors
  1. Q. Liu
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  2. L.-T. Wang
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  3. S.-Q. Dong
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  4. Zh.-X. Zhang
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  5. L. Zhao
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Correspondence to L. Zhao.

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Liu, Q., Wang, LT., Dong, SQ. et al. Preparation and Characterization of SiO2/SiO2 Core–Shell Microspheres as RP-HPLC Stationary Phase. J Inorg Organomet Polym 21, 941–945 (2011). https://doi.org/10.1007/s10904-011-9549-8

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  • DOI: https://doi.org/10.1007/s10904-011-9549-8

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