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Synthesis and Characterization of Thermally Stable and Biologically Active Metal-Based Schiff Base Polymer

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Abstract

Schiff base was prepared via condensation of ethanedihydrazide with 2-hydroxy benzaldehyde and further this monomeric Schiff base polymerize with formaldehyde and barbituric acid and form polymeric Schiff base (PLSB) ligand. The ligand and its polymer metal complexes were characterized by using elemental analysis, IR, UV–VIS, 1HNMR, magnetic susceptibility and thermogravimetric studies. On basis of elemental analysis and spectral studies, six coordinated geometry was assigned for Mn(II), Co(II) and Ni(II) complexes and four coordinated for Cu(II) and Zn(II) complexes. PLSB act as a tetradentate and coordinate through the azomethine nitrogen and phenolic oxygen. The thermal behavior of these polymer metal complexes showed that the hydrated complexes losses water molecules of hydration in the first step followed immediately by decomposition of the anions and ligand molecules in the subsequent steps. The (PLSB) ligands and its polymer metal complexes were screened against bacterial species Escherichia coli, Staphylococcus aureus, Bacillus subtilis and fungal species Aspergillus flavus, Candida albicans, A. niger. The activity data show that the metal complexes were more potent than the parent Schiff bases.

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References

  1. B.S. Tovrog, D.J. Kitko, R.S. Dragom, J. Am. Chem. Soc. 98, 5144 (1976)

    Article  CAS  Google Scholar 

  2. X. Wang, Q. Zhanng, Eur. Polym. J. 40, 385 (2004)

    Article  CAS  Google Scholar 

  3. P.J. Larkin, M.P. Makowski, N.B. Colthup, L.A. Flood, Vib. Spectrosc. 17, 53 (1998)

    Article  CAS  Google Scholar 

  4. H. Sharghi, M.A. Nasseri, Bull. Chem. Soc. (Jpn.) 76, 137 (2003)

    Article  CAS  Google Scholar 

  5. M.R. Filipovic, K. Duerr, M. Mojovic, V. Simeunovic, R. Zimmermann, V. Niketic, I. Ivanovic-Burmazovic, Angew. Chem. Int. Ed. Eng. 47, 8735 (2008)

    Article  CAS  Google Scholar 

  6. K.B. Gudasi, M.S. Patil, R.S. Vadavi, R.V. Shenoy, S.A. Patil, M. Nethaji, Trans. Met. Chem. 31, 580 (2006)

    Article  CAS  Google Scholar 

  7. D.H. Brown, W.E. Smith, J.W. Teape, A.J. Lewis, J. Med. Chem. 23, 729 (1980)

    Article  CAS  Google Scholar 

  8. A. Scozzafava, L. Menabuoni, F. Mincione, G. Mincione, C.T. Supuran, Bioorg. Med. Chem. Lett. 11, 575 (2001)

    Article  CAS  Google Scholar 

  9. A. Scozzafana, C.T. Supuran, J. Med. Chem. 43, 3677 (2000)

    Article  Google Scholar 

  10. G. Alzuet, J. Casanova, J. Borras, S.G. Granda, A.G. Rodriguez, C.T. Supuran, Inorg. Chim. Acta 273, 334 (1998)

    Article  CAS  Google Scholar 

  11. C.T. Supuran, A. Scozzafava, Eur. J. Med. Chem. 35, 867 (2000)

    Article  CAS  Google Scholar 

  12. A.J. Crowe, Metal Base Antitumour Drugs, ed. by M. Gielen, vol 1 (Freund, London, 1988)

  13. R.S. Srivastava, Ind. J. Chem. 29, 1024 (1990)

    Google Scholar 

  14. A.Y. Louie, T.J. Meade, Chem. Rev. 99, 2711 (1999)

    Article  CAS  Google Scholar 

  15. V.L. Damaraju, S. Damaraju, J.D. Young, S.A. Baldwin, J. Mackey, M.B. Sawyer, C.E. Cass, Oncog 22, 7524 (2003)

    Article  CAS  Google Scholar 

  16. C. Walsh, Nat 409, 226 (2001)

    Article  CAS  Google Scholar 

  17. I. Bertini, H.B. Gray, S.J. Lippard, J.S. Valentine, Bioinorganic Chemistry (University Science Books, Mill Valley, California, 1994)

    Google Scholar 

  18. R.K. Watt, P.W. Ludden, Cell. Mol. Life Sci. 56, 604 (1999)

    Article  CAS  Google Scholar 

  19. M.Y. Khuhawar, A.G. Bhatti, M.A. Qureshi, Z.P. Memon, F.C. Nachnani, J. Chem. Soc. Pak. 6, 103 (1984)

    CAS  Google Scholar 

  20. W.R. Frisell, Human Biochemistry (Macmillan, New York;, 1982)

    Google Scholar 

  21. K. Nakamoto, Infrared Spectra of Inorganic and Coordination Compounds, 2nd edn. (Wiley Interscience, New York, 1970)

    Google Scholar 

  22. I. Kaya, J. Inorg. Organomet. Polym. 20, 369 (2010)

    Article  CAS  Google Scholar 

  23. K.V. Ribalka, D.T. Radzhabov, A.V. Ragimov, Sborn Elektrotekhnich Promishl. 2(95), 20 (1984)

    Google Scholar 

  24. I. Manners, Angew. Chem. Int. Ed. Engl. 35, 1602 (1996)

    Article  Google Scholar 

  25. G.C. Bassler, R.M. Silverstein, Spectrophotometric Identification of Organic Compounds, 3rd edn. (Wiley, New York, 1992), pp. 109–112

    Google Scholar 

  26. V. Reddy, N. Patil, T. Reddy, S.G. Angadi. E-J. Chem. 5, 529 (2008)

    Google Scholar 

  27. L.J. Bellamy, The infrared spectra of complex molecules, vol. 2, 2nd edn. (Chapman and Hall, London, 1980), p. 299

    Book  Google Scholar 

  28. C. Jayalarilankan, K. Natarajan, Synth. React. Inorg. Met. Org. Chem. 31, 983 (2001)

    Article  Google Scholar 

  29. S.C. Gagieva, T.A. Sukhova, D.V. Savinov, V.A. Optov, N.M. Bravaya, Y.M. Belokon, B.M. Bulychev, J. Appl. Polym. Sci. 95, 1040 (2005)

    Article  CAS  Google Scholar 

  30. N.H. Patel, K.N. Patel, M.N. Patel, Synth. React. Inorg. Met. Org. Chem. 32, 1879 (2002)

    Article  CAS  Google Scholar 

  31. J.R. Dyer, Application of absorption spectroscopy of organic compounds (Prentice hall, Englewood Cliffs, 1984), p. 90

    Google Scholar 

  32. A.B.P. Lever, Inorganic Electronic Spectroscopy (Elsevier, Amsterdam, London, New York, 1968), pp. 317–327

    Google Scholar 

  33. S. Chandra, K. Gupta, Ind. J. Chem. 40A, 775 (2001)

    CAS  Google Scholar 

  34. A. Bajpai, S. Rai, J. Appl. Polym. Sci. 69, 751 (1998)

    Article  CAS  Google Scholar 

  35. R.L. Carlin, Transition Metal Chemitry (Marcel Decker, New York, 1965), p. 1

    Google Scholar 

  36. S.M. Roy, H.D. Juneja, K.N. Munshi, J. Therm. Anal. Cal. 65, 197 (2001)

    Article  CAS  Google Scholar 

  37. A.V. Nikolaev, V.A. Longvinenko, L.T. Myachina, Thermal analysis (Academic Press, New York, 1960), p. 779

    Google Scholar 

  38. R. Olar, M. Badea, E. Cristurean, V. Lazar, R. Cernat, C. Balotescu, J. Therm. Anal. Cal. 80, 451 (2005)

    Article  CAS  Google Scholar 

  39. C.M. Sharaby, Spectrochim. Acta Part A. 66, 1271 (2007)

    Article  Google Scholar 

  40. H.L. Singh, S. Varshney, A.K. Varshney, Appl. Organomet. Chem. 14, 212 (2000)

    Article  CAS  Google Scholar 

  41. K.B. Gudasi, M.S. Patil, R.S. Vadavi, Euro. J. Med. Chem. 43, 2436 (2008)

    Article  CAS  Google Scholar 

  42. V.L. Siji, M.R.S. Kumar, S. Suma, M.R.P. Kurup, Spectrochim. Acta Part A. 76, 22 (2010)

    Article  CAS  Google Scholar 

  43. V.P. Singh, A. Katiyar, Pest. Biochem. Physio. 92, 8 (2008)

    Article  CAS  Google Scholar 

  44. S.K. Sengupta, O.P. Pandey, B.K. Srivastava, V.K. Sharma, Trans. Met. Chem. 23, 349 (1998)

    Article  CAS  Google Scholar 

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Acknowledgments

S. A. Khan is thankful to UGC (New Delhi, India) for financial assistance. The authors express their sincere thanks to The Third World Academy of Sciences, Italy for UV-Visible spectrophotometer EZ-201 (PerkinElmer) through research grant scheme No. 00-047 RG/CHE/AS.

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  1. Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi, 110025, India

    Nahid Nishat, Shamim Ahmad Khan, Raza Rasool & Shadma Parveen

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  1. Nahid Nishat
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  2. Shamim Ahmad Khan
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  3. Raza Rasool
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  4. Shadma Parveen
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Correspondence to Nahid Nishat.

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Nishat, N., Khan, S.A., Rasool, R. et al. Synthesis and Characterization of Thermally Stable and Biologically Active Metal-Based Schiff Base Polymer. J Inorg Organomet Polym 22, 455–463 (2012). https://doi.org/10.1007/s10904-011-9592-5

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  • DOI: https://doi.org/10.1007/s10904-011-9592-5

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