Skip to main content
SpringerLink
Log in

Polymer complexes: LXXX—characterization, DNA cleavage properties, antimicrobial activity and molecular docking studies of transition metal complexes of Schiff base

  • Original Paper
  • Published:
Journal of the Iranian Chemical Society Aims and scope Submit manuscript

Abstract

A new series of polymer complexes of Cu(II), Co(II), Ni(II), Mn(II) and Cd(II) with 4-[(2,4-dihydroxy-benzylidene)-amino]-1,5-dimethyl-2-phenyl-1,2-dihydroxo-pyrazol-3-one (H2L) ligand were prepared and characterized. From the elemental analysis data, the polymer complexes were proposed to have the general formula {[M(L)(OH2)2]·xH2O}n where M = Cu(II)(1), x = 1.25; M = Co(II)(2), Ni(II)(3), Mn(II)(4) and Cd(II)(5), x = nil. The molar conductance data revealed that all the polymer complexes were non-electrolytes. The synthesized ligand, in comparison with its metal polymer complexes, was screened for their antibacterial activity against bacterial species. It was found that the metal complexes have more antimicrobial activities than the Schiff base ligand against some microbial species. Some complexes showed higher activity than ligand. The antibacterial activity of Cd(II) complex (5) was the highest ones than the ligand and other complexes as well as penicillin G against Bacillus cereus, Staphylococcus aureus and Pseudomonas sp. The anticandidal activity of Cd(II) complex (5) was the highest ones than the ligand and other complexes as well as miconazole against Candida albicans.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Scheme 1
Scheme 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12

Similar content being viewed by others

References

  1. A.Z. El-Sonbati, M.A. Diab, Sh.M. Morgan, H.A. Seyam, J. Mol. Struct. 1154, 354 (2018)

    Article  CAS  Google Scholar 

  2. A. Sahraei, H. Kargar, M. Hakimi, M.N. Tahir, Transit. Met. Chem. 42, 483 (2017)

    Article  CAS  Google Scholar 

  3. Sh.M. Morgan, A.Z. El-Sonbati, H.R. Eissa, J. Mol. Liq. 240, 752 (2017)

    Article  CAS  Google Scholar 

  4. S.N. Buttrus, Res. J. Chem. Sci. 4, 41 (2014)

    CAS  Google Scholar 

  5. K.B. Sindhu, G. Raijuulal, K. Mohanan, Synth. React. Inorg. Metal-Org. Nano-Metal Chem. 39, 24 (2009)

    Article  Google Scholar 

  6. N. Raman, J.R. Dhaveethu, A. Sakthivel, J. Chem. Sci. 119, 303 (2007)

    Article  CAS  Google Scholar 

  7. A. Corona-Bustamante, J.M. Viveros-Paredes, A. Flores-Parraet, Molecules 15, 5445 (2010)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. N. Raja, R. Ramesh, Spectrochim. Acta A 75, 713 (2010)

    Article  CAS  Google Scholar 

  9. M. Joseph, A. Sreekanth, V. Suni, M.R.P. Kurup, Spectrochim. Acta A 64, 637–641 (2006)

    Article  Google Scholar 

  10. A.A. El-Sherif, Inorg. Chim. Acta 362, 4991 (2009)

    Article  CAS  Google Scholar 

  11. M. Aghaei, A.H. Kianfar, M. Dinari, App. Organomet. Chem. 34, e5617 (2020)

    Article  CAS  Google Scholar 

  12. M. Dostani, A.H. Kianfar, W.A.K. Mahmood, M. Dinari, H. Farrokhpour, M.R. Sabzalian, F. Abyar, M.H. Azarian, Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 180, 144 (2017)

    Article  CAS  Google Scholar 

  13. H. Kargar, M. Fallah-Mehrjardi, R. Behjatmanesh-Ardakani, H.A. Rudbari, A.A. Ardakani, S. Sedighi-Khavidak, KhSh. Munawar, M. Ashfaq, M.N. Tahir, Inorg. Chim. Acta 530, 120677 (2022)

    Article  CAS  Google Scholar 

  14. H. Kargar, F. Aghaei-Meybodi, R. Behjatmanesh-Ardakani, M.R. Elahifard, V. Torabi, M. Fallah-Mehrjardi, M.N. Tahir, M. Ashfaq, KhSh. Munawar, J. Mol. Struct. 1230, 129908 (2021)

    Article  CAS  Google Scholar 

  15. H. Kargar, F. Aghaei-Meybodi, M.R. Elahifard, M.N. Tahir, M. Ashfaq, Kh. Shahzad, J. Coord. Chem. 74, 1534 (2021)

    Article  CAS  Google Scholar 

  16. M.I. Abou-Dobara, N.F. Omar, M.A. Diab, A.Z. El-Sonbati, Sh.M. Morgan, O.L. Salem, A.M. Eldesoky, Mat. Sci. Eng. C 103, 109727 (2019)

    Article  CAS  Google Scholar 

  17. H. Raouf, S.A. Beyramabadi, S. Allameh, A. Morsali, J. Mol. Struct. 1179, 779 (2019)

    Article  CAS  Google Scholar 

  18. M. Aghaei, A.H. Kianfar, M. Dinari, J. Polym. Res. 27, 54 (2020)

    Article  CAS  Google Scholar 

  19. M. Aghaei, A.H. Kianfar, M. Dinari, J. Iran. Chem. Soc. 16, 2489 (2019)

    Article  CAS  Google Scholar 

  20. S.A. Aboafia, Sh.A. Elsayed, A.K.A. El-Sayed, A.M. El-Hendawy, J. Mol. Struct. 1158, 39 (2018)

    Article  CAS  Google Scholar 

  21. M. Vijayalakshmi, Rasayan J. Chem. 11, 857 (2018)

    Article  CAS  Google Scholar 

  22. M. Sedighipoor, A.H. Kianfara, Gh. Mohammadnezhada, H. Gorlsb, W. Plassb, A.A. Momtazi-Borojenic, E. Abdollahie, Inorg. Chim. Acta 488, 182 (2019)

    Article  CAS  Google Scholar 

  23. M. Sedighipoor, A.H. Kianfar, M.R. Sabzalian, F. Abyar, Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 198, 38 (2018)

    Article  CAS  Google Scholar 

  24. M. Sedighipoor, A.H. Kianfar, W.A.K. Mahmood, M.H. Azarian, Polyhedron 129, 1 (2017)

    Article  CAS  Google Scholar 

  25. K.M.P. Kumar, B.C.V. Kumar, P.R. Kumar, R.J. Butcher, H.K. Vivek, P.A. Suchetan, H.D. Revanasiddappa, S. Foro, Appl. Org. Chem. 34, e5634 (2020)

    Article  Google Scholar 

  26. R. Sarin, K.N. Mushi, J. Inorg. Nucl. Chem. 34, 581 (1972)

    Article  CAS  Google Scholar 

  27. A.Z. El-Sonbati, A.A.M. Belal, M.S. El-Gharib, Sh.M. Morgan, Spectrochim. Acta A 95, 627 (2012)

    Article  CAS  Google Scholar 

  28. A.Z. El-Sonbati, M.A. Diab, A.A.M. Belal, Sh.M. Morgan, Spectrochim. Acta A 99, 353 (2012)

    Article  CAS  Google Scholar 

  29. A.Z. El-Sonbati, M.A. Diab, Sh.M. Morgan, A.M. Eldesoky, M.Z. Balboula, Appl. Organomet. Chem. 32, e4207 (2018)

    Article  Google Scholar 

  30. Sh.M. Morgan, A.Z. El-Sonbati, M.A. El-Mogazy, Appl. Organomet. Chem. 32, e4264 (2018)

    Article  Google Scholar 

  31. N.A. El-Ghamaz, A.Z. El-Sonbati, Sh.M. Morgan, J. Mol. Struct. 1027, 92 (2012)

    Article  CAS  Google Scholar 

  32. R. Shirley, The CRYSFIRE system for automatic powder indexing: user's manual, the Lattice Press, Guildford, England Surrey GU2 7NL (2000)

  33. J. Laugier, B. Bochu, LMGP-suite suite of programs for the interpretation of X-ray experiments, ENSP/Laboratoire des Materiaux et du Genie Physique, BP46,38042, Saint Martin d'Heres, France (2000)

  34. T. Mosmann, J. Immunol. Methods 65, 55 (1983)

    Article  CAS  PubMed  Google Scholar 

  35. M.A. Diab, A.Z. El-Sonbati, Sh.M. Morgan, M.A. El-Mogazy, Appl. Organomet. Chem. 32, e4378 (2018)

    Article  Google Scholar 

  36. S.M. Gomha, S.M. Riyadh, E.A. Mahmmoud, M.M. Elaasser, Heterocycles 91, 1227 (2015)

    Article  CAS  Google Scholar 

  37. A.Z. El-Sonbati, M.A. Diab, Sh.M. Morgan, J. Mol. Liq. 225, 195 (2017)

    Article  CAS  Google Scholar 

  38. Sh.M. Morgan, N.A. El-Ghamaz, M.A. Diab, J. Mol. Struct. 1160, 227 (2018)

    Article  CAS  Google Scholar 

  39. H.M. Refaat, H.A. El-Badway, Sh.M. Morgan, J. Mol. Liq. 220, 802 (2016)

    Article  CAS  Google Scholar 

  40. G.G. Mohamed, A.A. El-Sherif, M.A. Saad, S.E.A. El-Sawy, Sh.M. Morgan, J. Mol. Liq. 223, 1311 (2016)

    Article  CAS  Google Scholar 

  41. A. Jamshidvand, M. Sahihi, V. Mirkhani, M. Moghadam, I. Mohammadpoor-Baltork, Sh. Tangestaninejad, H.A. Rudbari, H. Kargar, R. Keshavarzi, S. Gharaghani, J. Mol. Liq. 253, 61 (2018)

    Article  CAS  Google Scholar 

  42. Sh.M. Morgan, M.A. Diab, A.Z. El-Sonbati, Appl. Organomet. Chem. 32, e4504 (2018)

    Article  Google Scholar 

  43. H. Kargar, R. Behjatmanesh-Ardakani, V. Torabi, M. Kashani, Z. Chavoshpour-Natanzi, Z. Kazemi, V. Mirkhani, A. Sahraei, M.N. Tahir, M. Ashfaq, KhSh. Munawar, Polyhedron 195, 114988 (2021)

    Article  CAS  Google Scholar 

  44. H. Kargar, R. Behjatmanesh-Ardakani, V. Torabi, A. Sarvian, Z. Kazemi, Z. Chavoshpour-Natanzi, V. Mirkhani, A. Sahraei, M.N. Tahir, M. Ashfaq, Inorg. Chim. Acta 514, 120004 (2021)

    Article  CAS  Google Scholar 

  45. M.I. Abou-Dobara, N.F. Omar, M.A. Diab, A.Z. El-Sonbati, M.S. Morgan, M.A. El-Mogazy, J. Cell. Biochem. 120, 1667 (2019)

    Article  CAS  PubMed  Google Scholar 

  46. M.I. Abou-Dobara, A.Z. El-Sonbati, Sh.M. Morgan, World J. Microbiol. Biotechnol. 29, 119 (2013)

    Article  CAS  PubMed  Google Scholar 

  47. J. Sambrook, D. Russell, Molecular cloning. A Laboratory Manual, 3rd edn. (Cold Spring Harbour Lab. Press, New York, 2001)

  48. S.Y. Wang, C.L. Wu, F.H. Chu, S.C. Chien, Y.H. Kuo, L.F. Shyur, S.T. Chang, Holzforschung 59, 295 (2005)

    Article  CAS  Google Scholar 

  49. A.Z. El-Sonbati, M.A. Diab, A.M. Eldesoky, Sh.M. Morgan, O.L. Salem, Appl. Organomet. Chem. 33, e4839 (2019)

    Article  Google Scholar 

  50. S. Chandra, S. Raizada, M. Tyagi, P. Sharma, Spectrochim. Acta A 69, 816 (2008)

    Article  Google Scholar 

  51. L.F. Lindoy, W.E. Moody, D. Taylor, Inorg. Chem. 16, 1962 (1997)

    Article  Google Scholar 

  52. C.H. Thirupataiah, D.P. Chary, M. Ravinder, S. Srihari, Orient. J. Chem. 24, 859 (2008)

    CAS  Google Scholar 

  53. I.M. Issa, R.M. Issa, Y.M. Temark, M.M. Ghoneim, Egypt. J. Chem. 18, 11 (1975)

    Google Scholar 

  54. G. Karagonius, O. Peter, Z. Electrochem. Ber. Bunseges. Phys. Chem. 63, 1170 (1959)

  55. M.M.A. Abou Sekkina, S.M. El-Helhuwy, Proc. Indian Nucl. Sci. 51, 946 (1985)

    Google Scholar 

  56. D.M. Boghaei, S.J.S. Sabounechei, S. Rayati, Synth. React. Inorg. Met. Org. Chem. 30, 1535 (2000)

    Article  CAS  Google Scholar 

  57. R.K. Ray, K.B. George, Inorg. Chim. Acta. 173, 207 (1990)

    Article  CAS  Google Scholar 

  58. R.K. Ray, K.B. George, Inorg. Chim. Acta. 174, 257 (1990)

    Article  CAS  Google Scholar 

  59. P.W. Selwood, Magnetochemistry (Interscience, New York, London, 1956)

    Google Scholar 

  60. A.M. Attallah, M. El- Far, M.E.A. Fatah, M.M. Omran, M.A. Abdelrazek, G.E. Abdelhameed, K.A. Attallah, N.A. Ahmed, E.A. El-sayes, F.M. Khedr, I. El-Dosoky, J. Biosci. App. Res. 5, 212 (2019)

    Article  Google Scholar 

  61. G. Psomas, J. Inorg. Biochem. 102, 1798 (2008)

    Article  CAS  PubMed  Google Scholar 

  62. A. Sahraei, H. Kargar, M. Hakimi, M.N. Tahir, J. Mol. Str. 42, 483 (2017)

    CAS  Google Scholar 

  63. H. Kargar, A.A. Ardakani, KhSh. Munawar, M. Ashfaq, M.N. Tahir, J. Iran. Chem. Soc. 18, 2493 (2021)

    Article  CAS  Google Scholar 

  64. A.A. Ardakani, H. Kargar, N. Feizi, M.N. Tahir, J. Iran. Chem. Soc. 15, 1495 (2018)

    Article  CAS  Google Scholar 

  65. A.Z. El-Sonbati, M.A. Diab, Sh.M. Morgan, M.Z. Balboula, Appl. Organomet. Chem. 32, e4059 (2018)

    Article  Google Scholar 

  66. G. Kumaravel, P.P. Utthra, N. Raman, Bioorg. Chem. 77, 269 (2018)

    Article  CAS  PubMed  Google Scholar 

  67. D. Śmiłowicz, N. Metzler-Nolte, J. Inorg. Biochem. 206, 111041 (2020)

    Article  PubMed  Google Scholar 

  68. W.-J. Lian, X.-T. Wang, C.-Z. Xie, He. Tian, X.-Q. Song, H.-T. Pan, X. Qiao, Xu. Jing-Yuan, Dalton Trans. 45, 9073 (2016)

    Article  CAS  PubMed  Google Scholar 

  69. Y.-X. Tai, Y.-M. Ji, Lu. Yan-Li, M.-X. Li, Wu. Yuan-Yuan, Q.-X. Han, Synth. Met. 219, 109 (2016)

    Article  CAS  Google Scholar 

  70. A.W. Coats, J.P. Redfern, Nature 201, 68 (1964)

    Article  CAS  Google Scholar 

  71. H.H. Horowitz, G. Metzger, Anal. Chem. 35, 1464 (1963)

    Article  CAS  Google Scholar 

  72. A.H. Kianfar, M. Bahramian, H.R. Khavasic, Spectrochim. Acta Part A 94, 302 (2012)

    Article  CAS  Google Scholar 

  73. Sh.M. Morgan, M.A. Diab, A.Z. El-Sonbati, Appl. Organometal. Chem. 32, e4305 (2018)

    Article  Google Scholar 

  74. Sh.M. Morgan, M.A. Diab, A.Z. El-Sonbati, Appl. Organometal. Chem. 32, e4281 (2018)

    Article  Google Scholar 

Download references

Acknowledgements

The authors are grateful to Dr. Mohamed Marzouk El-Zahed, Lecturer of Microbiology at Botany and Microbiology Department, Faculty of Science, Damietta University, for his effort for detecting antimicrobial activities of the synthesized compounds.

Author information

Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt

    M. A. Diab, H. R. Issa & A. Z. El-Sonbati

  2. Botany and Microbiology Department, Faculty of Science, Damietta University, Damietta, Egypt

    A. K. El-Sayed & M. I. Abou-Dobara

Authors
  1. M. A. Diab
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. K. El-Sayed
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. I. Abou-Dobara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. R. Issa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Z. El-Sonbati
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Z. El-Sonbati.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 670 kb)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Diab, M.A., El-Sayed, A.K., Abou-Dobara, M.I. et al. Polymer complexes: LXXX—characterization, DNA cleavage properties, antimicrobial activity and molecular docking studies of transition metal complexes of Schiff base. J IRAN CHEM SOC 20, 1283–1305 (2023). https://doi.org/10.1007/s13738-023-02755-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13738-023-02755-4

Keywords

Search

Navigation