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Polysilsesquioxanes and Oligosilsesquioxanes Substituted by Alkylammonium Salts as Antibacterial Biocides

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Abstract

Octa(3-chloropropylsilsesquioxane), (T-ClPr)8, and a soluble, low molecular weight, poly(3-chloropropylsilsesquioxane) were subjected to a reaction with dimethyl-n-octylamine to convert part or almost all the chloropropyl groups to corresponding quaternary ammonium salt (QAS) groups. Polysilsesquioxanes containing secondary n-amylammonium salt (SAS) groups were synthesized by reaction of n-alkyl bromides with poly(3-aminopropylsilsesquioxane) of limited molecular weight or by amination of n-amyl bromide with 3-aminopropyltriethoxysilane followed by hydrolysis and polycondensation. The antibacterial activity of these QAS- and SAS-containing silsesquioxane materials against two representative Gram-positive and three representative Gram-negative bacterium strains were tested. Most of these materials showed high or moderate activity against Gram-positive bacteria and moderate or weak activity against Gram-negative bacteria.

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Acknowledgments

The financial support by the Ministry of Education and Science of Republic of Poland, Grant 3 T09 B 06926 is highly appreciated. Authors are indebted to Dr Grzegorz Lapienis for the performing of the SEC analysis in water solution.

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Authors and Affiliations

  1. Center of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza, 90-363, Łódź, Poland

    J. Chojnowski & W. Fortuniak

  2. Institute of Industrial Chemistry, 8 Rydygiera, 01-793, Warsaw, Poland

    P. Rościszewski

  3. Gdańsk Medical University, 107 Hallera, 80-416, Gdańsk, Poland

    W. Werel, J. Łukasiak, W. Kamysz & R. Hałasa

Authors
  1. J. Chojnowski
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  2. W. Fortuniak
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  3. P. Rościszewski
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  4. W. Werel
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  5. J. Łukasiak
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  6. W. Kamysz
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  7. R. Hałasa
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Correspondence to J. Chojnowski.

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Chojnowski, J., Fortuniak, W., Rościszewski, P. et al. Polysilsesquioxanes and Oligosilsesquioxanes Substituted by Alkylammonium Salts as Antibacterial Biocides. J Inorg Organomet Polym 16, 219–230 (2006). https://doi.org/10.1007/s10904-006-9048-5

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  • DOI: https://doi.org/10.1007/s10904-006-9048-5

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