Abstract
Purpose: Examine young adults' attitudes about HFE genotyping. Methods: 121 college students read about hemochromatosis, transferrin saturation measurement (iron test), and HFE genotyping. Interest in testing and knowledge and attitudes about genetic testing were assessed. Participants were randomly assigned to predict either their response to a positive HFE genotype (genotype group) or a positive iron test (phenotype group). Results: 71% preferred the iron test, but most would undergo either test. Learning risk and early detection/prevention were the most commonly perceived benefits; limited information about health and negative emotional consequences were the most commonly perceived disadvantages. The genotype and phenotype groups did not differ in expected worry, perceived severity, perceived risk, and preventability of organ damage. After reading the description provided, participants answered 78% of knowledge questions correctly. Conclusions: Young adults view HFE genotyping positively and report few disadvantages, but prefer the iron test for its information about current health. They appear to be receptive to public health screening for hemochromatosis.
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Aro, A. R., Hakonen, A., Hietala, M., Lonnqvist, J., Niemela, P., Peltonen, L., & Aula, P. (1997). Acceptance of genetic testing in a general population: age, education and gender differences. Patient Educ Couns, 32(1–2), 41–49.
Axworthy, D., Brock, D. J., Bobrow, M., & Marteau, T. M. (1996). Psychological impact of population-based carrier testing for cystic fibrosis: 3-year follow-up. UK Cystic Fibrosis Follow-Up Study Group. Lancet, 347(9013), 1443–1446.
Bowen, D. J., Burke, W., Yasui, Y., McTiernan, A., & McLeran, D. (2002). Effects of risk counseling on interest in breast cancer genetic testing for lower risk women. Genet Med, 4(5), 359–365.
Brooks, L., Lennard, F., Shenton, A., Lalloo, F., Ambus, I., Ardern-Jones, A., Belk, R., et al. (2004). BRCA1/2 predictive testing: a study of uptake in two centres. Eur J Hum Genet, 12(8), 654–662.
Burke, W., Thomson, E., Khoury, M. J., McDonnell, S. M., Press, N., Adams, P. C., Barton, J. C., et al. (1998). Hereditary hemochromatosis: gene discovery and its implications for population-based screening. JAMA, 280(2), 172–178.
Clayton, C., Hall, P., & Mackinnon, M. (1993). Family screening for genetic haemochromatosis. The Medical Journal of Australia, 159, 614–615.
Foster, C., Evans, D. G., Eeles, R., Eccles, D., Ashley, S., Brooks, L., Cole, T., et al. (2004). Non-uptake of predictive genetic testing for BRCA1/2 among relatives of known carriers: attributes, cancer worry, and barriers to testing in a multicenter clinical cohort. Genet Test, 8(1), 23–29.
Gleeson, F., Ryan, E., Barrett, S., & Crowe, J. (2004). Clinical expression of haemochromatosis in Irish C282Y homozygotes identified through family screening. Eur J Gastroenterol Hepatol, 16(9), 859–863.
Hicken, B. L., Barton, J. C., Calhoun, D. A., & Tucker, D. C. (2004). Attitudes about and psychosocial outcomes of HFE genotyping for hemochromatosis. Genet Test, 8(2), 90–97.
Hicken, B. L., Calhoun, D. C., & Tucker, D. C. (2003). Genetic testing for hemochromatosis: Attitudes and acceptability among young and older adults. Genet Test, 7(3), 235–239.
Marteau, T. M., van Duijn, M., & Ellis, I. (1992). Effects of genetic screening on perceptions of health: a pilot study. J Med Genet, 29(1), 24–26.
McDonnell, S. M., Phatak, P. D., Felitti, V., Hover, A., & McLaren, G. D. (1998). Screening for hemochromatosis in primary care settings. Ann Intern Med, 129(11S), 962–970.
McLaren, C. E., Barton, J. C., Adams, P. C., Harris, E. L., Acton, R. T., Press, N., Reboussin, D. M., et al. (2003). Hemochromatosis and Iron Overload Screening (HEIRS) study design for an evaluation of 100,000 primary care-based adults. Am J Med Sci, 325(2), 53–62.
Murray, T. H. (1997). Genetic exceptionalism and “future diaries”: Is genetic information different from other medical information? In M. A. Rothstein (Ed.), Genetic secrets: protecting privacy and confidentiality in the genetic era (Vol. 1, pp. 60–73). New Haven, CT: Yale University Press.
Penson, R. T., Seiden, M. V., Shannon, K. M., Lubratovich, M. L., Roche, M., Chabner, B. A., & Lynch, T. J., Jr. (2000). Communicating genetic risk: pros, cons, and counsel. Oncologist, 5(2), 152–161.
Petty, E. (2001). When we discuss genetics, our words have different meanings: examination of African American and Caucasian adults' understanding of genetics and related implications. Paper presented at the Presentation at A Decade of ELSI Research Conference, Bethesda, Maryland.
Powell, L. W., & Bassett, M. L. (1998). Haemochromatosis: diagnosis and management after the cloning of the HFE gene. Australian & New Zealand Journal of Medicine, 28(2), 159–163.
Press, N. A., Yasui, Y., Reynolds, S., Durfy, S. J., & Burke, W. (2001a). Women's interest in genetic testing for breast cancer susceptibility may be based on unrealistic expectations. American Journal of Medical Genetics., 99(2), 99–110.
Press, N. A., Yasui, Y., Reynolds, S., Durfy, S. J., & Burke, W. (2001b). Women's interest in genetic testing for breast cancer susceptibility may be based on unrealistic expectations. Am J Med Genet, 99(2), 99–110.
Senior, V., Marteau, T., & Weinman, J. (2000). Impact of genetic testing on causal models of heart disease and arthritis: an analogue study. Psychol Health Med, 14, 1077–1088.
Senior, V., Marteau, T. M., & Peters, T. J. (1999a). Will genetic testing for predisposition for disease result in fatalism? A qualitative study of parents' responses to neonatal screening for familial hypercholesterolaemia. Soc Sci Med, 48, 1857–1860.
Senior, V., Marteau, T. M., & Peters, T. J. (1999b). Will genetic testing for predisposition for disease result in fatalism? a qualitative study of parents' responses to neonatal screening for familial hypercholesterolaemia. Social Science and Medicine, 48, 1857–1860.
Stemler, S. (2001). An overview of content analysis. Practical Assessment, Research, and Evaluation, 7(17), Online Journal.
Weinstein, N. D. (1982). Unrealistic optimism about susceptibility to health problems. J Behav Med, 5(4), 441–460.
Wroe, A. L., Salkovskis, P. M., & Rimes, K. A. (1998). The prospect of predictive testing for personal risk: attitudes and decision making. Beh Res Therapy, 36(6), 599–619.
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Hicken, B.L., Foshee, A. & Tucker, D.C. Perceptions and Attitudes about HFE Genotyping Among College-Age Adults. J Genet Counsel 14, 465–472 (2005). https://doi.org/10.1007/s10897-005-4718-y
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DOI: https://doi.org/10.1007/s10897-005-4718-y