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Fashionable Co-operative Sensing of Bivalent Zn2+ and Cd2+ in Attendance of OAc− by Use of Simple Sensor: Exploration of Molecular Logic Gate and Docking Studies

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Abstract

The Schiff-base probe H2VL [6,6'-((1E,1'E)-hydrazine-1,2 diylidenebis(methanylylidene))bis(2-methoxyphenol)] is synthesized and structurally characterized by single crystal X-ray diffraction (SCXRD). H2VL is able to detect selectively acetate ion (OAc-) colorimetrically over other anions with 1:1 co-ordination. The detection limit is found to be 4.93 µM. On the other hand, fluorescence intensity of the receptor is drastically enhanced with Zn2+ and Cd2+ in the presence of acetate as counter anion. N, N-Dimethyl formamide (DMF) or Dimethylsulphoxide (DMSO) and acetate (OAc-) was the best solvent and counter anion for Zn2+/Cd2+ -sensing compared with other solvents and anions, respectively. Detection limit for Zn2+ and Cd2+ are calculated to be 1.94 µM and 1.99 µM, respectively. The strong selective emissive behavior could be attributed to the CHEF (chelation-enhanced fluorescence) process. According to the changes in output emission intensity in DMSO in response to the set of ions (Zn2+, Cd2+ and OAc¯) as input variables, the function of 3-input multifunctional molecular logic circuits has been demonstrated. The molecular docking studies of H2VL with DNA and BSA are also performed to confirm its possible bioactivity.

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Raw data and materials are available on request to the author.

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Acknowledgements

M. Dolai thanks to Prabhat Kumar College, Contai for the constant support for carrying out the research. S. Pakrashy acknowledges CSIR-NET, New Delhi for the support of fellowship. This work was funded by the researcher supporting project (RSP-2021/259), King Saud University, Riyadh, Saudi Arabia.

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Author notes

  1. Bhriguram Das

    Present address: Mahammadpur Satya Smriti Sikshaniketan, Nandakumar, PurbaMedinipur, WB, 721632, India

Authors and Affiliations

  1. Department of Chemistry, Vidyasagar University, Paschim Medinipur, 721102, WB, India

    Bhriguram Das

  2. Department of Chemistry, Prabhat Kumar College, Purba Medinipur, 721404, WB, India

    Sourav Pakrashy, Gopal Chandra Das, Upasana Das & Malay Dolai

  3. Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    Fatmah Ali Alasmary & Saikh Mohammad Wabaidur

  4. Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK

    Md Ataul Islam

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  1. Bhriguram Das
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Contributions

All the authors (B. Das, S. Pakrashy, G. Das, U. Das, F. A. Alasmary, S. M. Wabaidur, M. A. Islam, and M. Dolai) contributed to the study conception and made substantial contribution while preparing the manuscript. All authors read and approved the final manuscript.

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Das, B., Pakrashy, S., Das, G.C. et al. Fashionable Co-operative Sensing of Bivalent Zn2+ and Cd2+ in Attendance of OAc− by Use of Simple Sensor: Exploration of Molecular Logic Gate and Docking Studies. J Fluoresc 32, 1263–1277 (2022). https://doi.org/10.1007/s10895-022-02980-9

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