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A Fluorescent Visual Proton Donor and Photoacid Sterilant Based on Sulfonate‐conjugated BODIPY

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Abstract

Increasing acidity is an effective method for bacterial inactivation by inhibiting the synthesis of intracellular proteins at low pH. Photo-driven proton release probe can be used for the measurement of proton in hydrophobic condition. To develop fluorescent proton donor, two boron dipyrromethene derivatives (BDP-S and BDP-S2) were characterized by spectroscopic methods. Irradiation of BDP-S by white LED light resulted in efficient generation of acidic species with changes of fluorescence emission. The linear relationship between the pH value and the fluorescence intensity of BDP-S was obtained, indicating that BDP-S is a fluorescent visual proton donor. Light-induced antibacterial results indicate that BDP-S can significantly inhibit the growth of E. coli. The results prove that BDP-S is a very promising photoacid sterilant.

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The data used to support the findings of this study are included within the article.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (21701056).

Funding

This work was financially supported by the National Natural Science Foundation of China (21,701,056).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China

    Abbas Mohammed Ali, Jian Shao, Jia-Xin Wang, Qiu-Yun Chen, Yang Li & Ling-Ling Qu

Authors
  1. Abbas Mohammed Ali
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  2. Jian Shao
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  3. Jia-Xin Wang
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  4. Qiu-Yun Chen
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  5. Yang Li
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  6. Ling-Ling Qu
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Contributions

All authors contributed to the study conception and design. Conceptualization: Qiu-Yun Chen; Methodology: Ling-Ling Qu; Formal analysis and investigation: Abbas Mohammed Ali, Jian Shao, Jia-Xin Wang and Yang Li; Writing- original draft preparation: Abbas Mohammed Ali; Writing - review and editing: Qiu-Yun Chen and Ling-Ling Qu; Funding acquisition: Ling-Ling Qu; Supervision: Qiu-Yun Chen.

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Correspondence to Qiu-Yun Chen or Ling-Ling Qu.

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Ali, A.M., Shao, J., Wang, JX. et al. A Fluorescent Visual Proton Donor and Photoacid Sterilant Based on Sulfonate‐conjugated BODIPY. J Fluoresc 31, 501–507 (2021). https://doi.org/10.1007/s10895-021-02682-8

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  • DOI: https://doi.org/10.1007/s10895-021-02682-8

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