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Methyl-β-Cyclodextrin /Cetyltrimethyl Ammonium Bromide Synergistic Sensitized Fluorescence Method for the Determination of Levofloxacin

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Abstract

A novel method of methyl-β-cyclodextrin (methyl-β-CD) and cetyltrimethyl ammonium bromide (CTAB) synergistic sensitized fluorescence analysis to determine levofloxacin (LVFX) was developed. The results were shown that the fluorescence intensity of LVFX was increased a lot in the system of methyl-β-cyclodextrin-CTAB medium. Under the conditions of λex/em = 330/507 nm and pH 4.5, the linear range and the detection limit for LVFX were found to be 0.040 ~ 4.0 μg/mL and 0.3 ng/mL, respectively. The mechanism of sensitized fluorescence method was discussed by the solubilization capacity and the microenvironment of medium. The proposed method has been applied for the determination of LVFX in eye drops real samples and human serum with satisfactory recovery.

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Acknowledgments

The authors acknowledge the financial support from the National Natural Science Foundation of China (21375117) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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  1. College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, People’s Republic of China

    Qiuyi Ren & Xiashi Zhu

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  1. Qiuyi Ren
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  2. Xiashi Zhu
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Correspondence to Xiashi Zhu.

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Ren, Q., Zhu, X. Methyl-β-Cyclodextrin /Cetyltrimethyl Ammonium Bromide Synergistic Sensitized Fluorescence Method for the Determination of Levofloxacin. J Fluoresc 26, 671–677 (2016). https://doi.org/10.1007/s10895-015-1753-4

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  • DOI: https://doi.org/10.1007/s10895-015-1753-4

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