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Bioreactance-derived haemodynamic parameters in the transitional phase in preterm neonates: a longitudinal study

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Abstract

Bioreactance (BR) is a novel, non-invasive technology that is able to provide minute-to-minute monitoring of cardiac output and additional haemodynamic variables. This study aimed to determine the values for BR-derived haemodynamic variables in stable preterm neonates during the transitional period. A prospective observational study was performed in a group of stable preterm (< 37 weeks) infants in the neonatal service of Tygerberg Children’s Hospital, Cape Town, South Africa. All infants underwent continuous bioreactance (BR) monitoring until 72 h of life. Sixty three preterm infants with a mean gestational age of 31 weeks and mean birth weight of 1563 g were enrolled. Summary data and time series graphs were drawn for BR-derived heart rate, non-invasive blood pressure, stroke volume, cardiac output and total peripheral resistance index. All haemodynamic parameters were significantly associated with postnatal age, after correction for clinical variables (gestational age, birth weight, respiratory support mode). To our knowledge, this is the first paper to present longitudinal BR-derived haemodynamic variable data in a cohort of stable preterm infants, not requiring invasive ventilation or inotropic support, during the first 72 h of life. Bioreactance-derived haemodynamic monitoring is non-invasive and offers the ability to simultaneously monitor numerous haemodynamic parameters of global systemic blood flow. Moreover, it may provide insight into transitional physiology and its pathophysiology.

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All data are available upon request from corresponding author and available on SUNScholarData.

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Acknowledgements

We wish to thank our patients’ parents for allowing their participation in this research.

Funding

No funds, Grants or other financial support was received.

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Authors and Affiliations

  1. Division Neonatology, Dept. Pediatrics & Child Health, Stellenbosch University and Tygerberg Children’s Hospital, Cape Town, South Africa

    Lizelle Van Wyk & Johan Smith

  2. Pediatric Cardiology Unit, Dept. Pediatrics & Child Health, Stellenbosch University, Cape Town, South Africa

    John Lawrenson

  3. Division of Epidemiology and Biostatistics, Department of Global Health, Stellenbosch University, Cape Town, South Africa

    Carl J. Lombard

  4. Biostatistics Unit, South African Medical Research Council, Cape Town, South Africa

    Carl J. Lombard

  5. Division of Neonatology, Dept. of Perinatology, Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children’s Hospital, Nijmegen, The Netherlands

    Willem Pieter de Boode

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  1. Lizelle Van Wyk
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Contributions

Conceptualization: LVW, JS; Methodology: LVW, W-PB, Formal analysis and investigation: LVW, CL; Writing—original draft preparation: LVW, JS, JL, W-PB; Writing—review and editing: LVW, JS, JL, W-PB, CL; Supervision: JS, JL, W-PB.

Corresponding author

Correspondence to Lizelle Van Wyk.

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Conflict of interest

L Van Wyk declares that Amayezu Medical, South Africa, provided bioreactance monitors and sensors, but no monetary incentives were provided. WP de Boode declares research support by Cheetah Medical. Neither Amayezu Medical nor Cheetah Medical had any input into research design, statistical analysis or manuscript editing.

Ethical approval

Research was conducted in accordance with the World Medical Association Declaration of Helsinki. Research was approved by the Human Research Ethics Committee of the Stellenbosch University, Cape Town, South Africa.

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Parents of all study participants (neonates) provided written, informed consent.

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Van Wyk, L., Smith, J., Lawrenson, J. et al. Bioreactance-derived haemodynamic parameters in the transitional phase in preterm neonates: a longitudinal study. J Clin Monit Comput 36, 861–870 (2022). https://doi.org/10.1007/s10877-021-00718-9

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  • DOI: https://doi.org/10.1007/s10877-021-00718-9

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