Skip to main content

Advertisement

SpringerLink
Log in

The Attenuating Effect of Curcumin-Loaded Gold Nanoparticles and Its Combination with Pluchea indica Root Extract on Kidney Stone Induced Male Wistar Rats

  • Original Paper
  • Published:
Journal of Cluster Science Aims and scope Submit manuscript

Abstract

The focus of this research was to investigate the impact of combining curcumin-loaded gold nanoparticles (Au NPs) with P. indica root extracts on kidney stones formed in male Wistar rats. Besides, kidney stones were induced in male Wistar rats through the oral supplementation of 2% ethylene glycol mixed with drinking water. To evaluate the impact of P. indica-curcumin-Au NPs on kidney stones, the rats were given a dose of 150 mg/kg P. indica root extract, 100 mg/kg curcumin, and 100 ppm of gold nanoparticles via administration. Following the treatment, the Wistar rat’s kidney tissues were collected and analysed for further research. Curcumin is a primary active ingredient in turmeric that has shown significant biological, pharmacological and diverse effects, such as anti-inflammatory, antifibrotic, and antioxidant properties. Additionally, P. indica root extract has been shown to reduce the formation of oxalate stones in the kidneys. The presence of various phenolic compounds in P. indica such as flavonoids, quinic acids, thiophenes, terpenes, and sterols, are more likely to generate Au NPs. Subsequent addition of curcumin with P. indica root extract accelerates the formation of a complex with Au NPs which was confirmed by X-ray diffraction, UV- visible spectroscopy, Dynamic light scattering and Transmission electron microscopy results. The use of P. indica-curcumin-Au NPs relieved the oxidative stress response in the rat model by decreasing MDA content and raising GSH, CAT, GR, GPx, and SOD levels. Moreover, the combination efficiently inhibited the expression of IL-6, -SMA, collagen I, and MCP1 and protected kidney tissues from deterioration.

Graphical Abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

Data Availability

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

Reference

  1. M. E. Abd El-Hack, M. T. El-Saadony, A. A. Swelum, M. Arif, M. M. Abo Ghanima, M. Shukry, A. Noreldin, A. E. Taha, and K. A. El-Tarabily (2021). Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability. J. Sci. Food Agric. 101, 5747–5762. https://doi.org/10.1002/jsfa.11372.

    Article  CAS  PubMed  Google Scholar 

  2. A. Abhishek, S. Benita, M. Kumari, D. Ganesan, E. Paul, P. Sasikumar, A. Mahesh, S. Yuvaraj, T. Ramprasath, and G. S. Selvam (2017). Molecular analysis of oxalate-induced endoplasmic reticulum stress mediated apoptosis in the pathogenesis of kidney stone disease. J. Physiol. Biochem. 73, 561–573. https://doi.org/10.1007/s13105-017-0587-8.

    Article  CAS  PubMed  Google Scholar 

  3. T. Ahmad, M. A. Bustam, M. Irfan, M. Moniruzzaman, H. M. Anwaar Asghar, and S. Bhattacharjee (2018). Green synthesis of stabilized spherical shaped gold nanoparticles using novel aqueous Elaeis guineensis (oil palm) leaves extract. J. Mol. Struct. 1159, 167–173. https://doi.org/10.1016/j.molstruc.2017.11.095.

    Article  CAS  Google Scholar 

  4. S. Ahmed, M. M. Hasan, H. Khan, Z. A. Mahmood, and S. Patel (2018). The mechanistic insight of polyphenols in calcium oxalate urolithiasis mitigation. Biomed. Pharmacother. 106, 1292–1299. https://doi.org/10.1016/j.biopha.2018.07.080.

    Article  CAS  PubMed  Google Scholar 

  5. M. Akram, M. Idrees (2019) Progress and prospects in the management of kidney stones and developments in phyto-therapeutic modalities. Int. J. Immunopathol. Pharmacol. 33. https://doi.org/10.1177/2058738419848220

  6. A. A. A. Aljabali, Y. Akkam, M. S. Al Zoubi, K. M. Al-Batayneh, B. Al-Trad, O. A. Alrob, A. M. Alkilany, M. Benamara, and D. J. Evans (2018). Synthesis of gold nanoparticles using leaf extract of ziziphus zizyphus and their antimicrobial activity. Nanomaterials 8, 1–15. https://doi.org/10.3390/nano8030174.

    Article  CAS  Google Scholar 

  7. A. K. Barui, R. Kotcherlakota, V. S. Bollu, S. K. Nethi, and C. R. Patra, 11 - Biomedical and drug delivery applications of functionalized inorganic nanomaterials (Elsevier Ltd., Biopolymer-Based Composites, 2017). https://doi.org/10.1016/B978-0-08-101914-6.00011-9. .

    Book  Google Scholar 

  8. S. Biswas, M. Chawda, K. Thakur, R. Gudi, and J. Bellare (2021). Physicochemical variation in nanogold-based ayurved medicine suvarna bhasma produced by various manufacturers lead to different in vivo bioaccumulation profiles. J. Evidence-Based Integr. Med. 26, 1–12. https://doi.org/10.1177/2515690X211011064.

    Article  Google Scholar 

  9. P. Das, K. Kumar, A. Nambiraj, R. Rajan, R. Awasthi, K. Dua, and M. Himaja (2017). Potential therapeutic activity of Phlogacanthus thyrsiformis Hardow (Mabb) flower extract and its biofabricated silver nanoparticles against chemically induced urolithiasis in male Wistar rats. Int. J. Biol. Macromol. 103, 621–629. https://doi.org/10.1016/j.ijbiomac.2017.05.096.

    Article  CAS  PubMed  Google Scholar 

  10. O. M. El-Borady, M. S. Ayat, M. A. Shabrawy, and P. Millet (2020). Green synthesis of gold nanoparticles using Parsley leaves extract and their applications as an alternative catalytic, antioxidant, anticancer, and antibacterial agents. Adv. Powder Technol. 31, 4390–4400. https://doi.org/10.1016/j.apt.2020.09.017.

    Article  CAS  Google Scholar 

  11. F. Fatima, S. Siddiqui, and W. A. Khan (2021). Nanoparticles as novel emerging therapeutic antibacterial agents in the antibiotics resistant era. Biol. Trace Elem. Res. 199, 2552–2564.

    Article  CAS  PubMed  Google Scholar 

  12. Z. Ferdous and A. Nemmar (2020). Health impact of silver nanoparticles: a review of the biodistribution and toxicity following various routes of exposure. Int J Mol Sci. https://doi.org/10.3390/ijms21072375.

    Article  PubMed  PubMed Central  Google Scholar 

  13. A. Folorunso, S. Akintelu, A. K. Oyebamiji, S. Ajayi, B. Abiola, I. Abdusalam, and A. Morakinyo (2019). Biosynthesis, characterization and antimicrobial activity of gold nanoparticles from leaf extracts of Annona muricata. J. Nanostruct. Chem. 9, 111–117. https://doi.org/10.1007/s40097-019-0301-1.

    Article  CAS  Google Scholar 

  14. M. Gandhi, M. Aggarwal, S. Puri, and S. K. Singla (2013). Prophylactic effect of coconut water (Cocos nucifera L.) on ethylene glycol induced nephrocalcinosis in male wistar rat. Int. Braz. J. Urol. 39, 108–117. https://doi.org/10.1590/S1677-5538.IBJU.2013.01.14.

    Article  CAS  PubMed  Google Scholar 

  15. Y. H. Gonfa, F. B. Tessema, A. Bachheti, M. G. Tadesse, E. M. Eid, S. Abou Fayssal, B. Adelodun, K. S. Choi, I. Širić, P. Kumar, and R. K. Bachheti (2022). Essential oil composition of aerial part of Pluchea ovalis (Pers.) DC., silver nanoparticles synthesis, and larvicidal activities against fall armyworm. Sustain 14, 15785. https://doi.org/10.3390/su142315785.

    Article  CAS  Google Scholar 

  16. S. Gopi, A. Amalraj, S. Jude, K. Varma, T. R. Sreeraj, J. T. Haponiuk, and S. Thomas (2017). Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber. Mater. Sci. Eng. C 81, 20–31. https://doi.org/10.1016/j.msec.2017.07.037.

    Article  CAS  Google Scholar 

  17. A. Haghighatzadeh, M. Hosseini, B. Mazinani, M. Shokouhimehr, H. Wang, P. Zhou, J. Wang, Y. Wang, J. Wei, H. Zhan, R. Guo, Y. Y. Zhang, L. Munguti, F. Dejene, M. R. Delsouz Khaki, M. S. Shafeeyan, A. A. A. Raman, W. M. A. W. Daud, N. Mohamadi Zalani, B. Koozegar Kaleji, B. Mazinani, H. Fan, X. Zhao, J. Yang, X. Shan, L. Yang, Y. Y. Zhang, X. X. Li, M. Gao, A. M. Ferrari-Lima, R. P. De Souza, S. S. Mendes, R. G. Marques, M. L. Gimenes, N. R. C. Fernandes-Machado, Y. Chen, C. Zhang, W. Huang, C. Yang, T. Huang, Y. Situ, H. Huang, G. Yang, Z. Yan, T. Xiao, M. Konyar, H. C. Yatmaz, K. Öztürk, C. C. Pei, W. W. F. Leung, S. Siuleiman, N. Kaneva, A. Bojinova, K. Papazova, A. Apostolov, D. Dimitrov, P. Zhang, C. Shao, X. X. Li, M. M. Zhang, X. X. Zhang, Y. Sun, Y. Y. Liu, L. Li, X. X. Zhang, W. Zhang, L. Wang, X. Chen, Y. Gao, X. Xu, J. Wang, J. Tian, X. Wang, J. Dai, X. X. Liu, B. Pant, H. R. Pant, N. A. M. Barakat, M. Park, K. Jeon, Y. Choi, H. J. H. Y. Kim, M. M. Zhang, T. An, X. X. Liu, X. Hu, G. Sheng, J. Fu, H. R. Pant, B. Pant, R. K. Sharma, A. Amarjargal, H. J. H. Y. Kim, C. H. Park, L. D. Tijing, C. S. Kim, J. Wang, W. Mi, J. Tian, J. Dai, X. Wang, X. X. Liu, R. H. Tao, J. M. Wu, J. Z. Xiao, Y. P. Zhao, W. W. Dong, X. D. Fang, L. Zhao, M. Xia, Y. Y. Liu, B. Zheng, Q. Jiang, J. Lian, M. Jlassi, H. Chorfi, M. Saadoun, B. Bessaïs, H. R. Pant, C. H. Park, B. Pant, L. D. Tijing, H. J. H. Y. Kim, C. S. Kim, V. V. Gawade, N. L. Gavade, H. M. Shinde, S. B. Babar, A. N. Kadam, and K. M. Garadkar (2013). Synthesis, characterization, and photocatalytic properties of ZnO nano-flower containing TiO 2 NPs. Ceram. Int. 258, 281–289. https://doi.org/10.1016/j.jhazmat.2012.08.054.

    Article  CAS  Google Scholar 

  18. A. Hardy, D. Benford, T. Halldorsson, M. J. Jeger, H. K. Knutsen, S. More, H. Naegeli, H. Noteborn, C. Ockleford, A. Ricci, G. Rychen, J. R. Schlatter, V. Silano, R. Solecki, D. Turck, M. Younes, Q. Chaudhry, F. Cubadda, D. Gott, A. Oomen, S. Weigel, M. Karamitrou, R. Schoonjans, A. Mortensen (2018) Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health. EFSA J. 16. https://doi.org/10.2903/j.efsa.2018.5327

  19. S. J. Huang, J. Huang, Y. B. Yan, J. Qiu, R. Q. Tan, Y. Liu, Q. Tian, L. Guan, S. S. Niu, Y. Zhang, Z. Xi, Y. Xiang, and Q. Gong (2020). The renoprotective effect of curcumin against cisplatin-induced acute kidney injury in mice: involvement of miR-181a/PTEN axis. Ren. Fail. 42, 350–357. https://doi.org/10.1080/0886022X.2020.1751658.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. S. Jumiyati, F. A. Parumpu, Budiman (2021) Types and utilization identification of medicinal plants: developing strategy for non-timber forest products in buffer zone. IOP Conf. Ser. Earth Environ. Sci. https://doi.org/10.1088/1755-1315/870/1/012017

  21. P. Kaewtubtim, W. Meeinkuirt, S. Seepom, and J. Pichtel (2018). Phytomanagement of radionuclides and heavy metals in mangrove sediments of Pattani Bay, Thailand using Avicennia marina and Pluchea indica. Mar. Pollut. Bull. 127, 320–333. https://doi.org/10.1016/j.marpolbul.2017.12.021.

    Article  CAS  PubMed  Google Scholar 

  22. S. Kalakotla, N. Jayarambabu, G. K. Mohan, R. B. S. M. N. Mydin, and V. R. Gupta (2019). A novel pharmacological approach of herbal mediated cerium oxide and silver nanoparticles with improved biomedical activity in comparison with Lawsonia inermis. Colloids Surf. B Biointerfaces 174, 199–206. https://doi.org/10.1016/j.colsurfb.2018.11.014.

    Article  CAS  PubMed  Google Scholar 

  23. B. Kaleeswaran, S. Ramadevi, R. Murugesan, S. Srigopalram, T. Suman, and T. Balasubramanian (2019). Evaluation of anti-urolithiatic potential of ethyl acetate extract of Pedalium murex L. on struvite crystal (kidney stone). J. Tradit. Complement. Med. 9, 24–37. https://doi.org/10.1016/j.jtcme.2017.08.003.

    Article  CAS  PubMed  Google Scholar 

  24. R. Kanlaya and V. Thongboonkerd (2019). Protective effects of epigallocatechin-3-gallate from green tea in various kidney diseases. Adv. Nutr. 10, 112–121. https://doi.org/10.1093/advances/nmy077.

    Article  PubMed  PubMed Central  Google Scholar 

  25. T. Kaur, R. K. Bijarnia, S. K. Singla, and C. Tandon (2009). In vivo efficacy of Trachyspermum ammi anticalcifying protein in urolithiatic rat model. J. Ethnopharmacol. 126, 459–462. https://doi.org/10.1016/j.jep.2009.09.015.

    Article  CAS  PubMed  Google Scholar 

  26. J. Kaushik, S. Tandon, R. Bhardwaj, T. Kaur, S. K. Singla, J. Kumar, and C. Tandon (2019). Delving into the Antiurolithiatic potential of Tribulus terrestris extract through –in vivo efficacy and preclinical safety investigations in wistar rats. Sci. Rep. 9, 1–13. https://doi.org/10.1038/s41598-019-52398-w.

    Article  CAS  Google Scholar 

  27. T. Kobayashi, A. Okada, Y. Fujii, K. Niimi, S. Hamamoto, T. Yasui, K. Tozawa, and K. Kohri (2010). The mechanism of renal stone formation and renal failure induced by administration of melamine and cyanuric acid. Urol. Res. 38, 117–125. https://doi.org/10.1007/s00240-010-0254-9.

    Article  CAS  PubMed  Google Scholar 

  28. Y. Li, J. Zhang, H. Liu, J. Yuan, Y. Yin, T. Wang, B. Cheng, S. Sun, and Z. Guo (2019). Curcumin ameliorates glyoxylate-induced calcium oxalate deposition and renal injuries in mice. Phytomedicine 61, 152861. https://doi.org/10.1016/j.phymed.2019.152861.

    Article  CAS  PubMed  Google Scholar 

  29. Z. Li, L. Chang, X. Ren, Y. Hu, and Z. Chen (2021). Modulation of rat kidney stone crystallization and the relative oxidative stress pathway by green tea polyphenol. ACS Omega 6, 1725–1731. https://doi.org/10.1021/acsomega.0c05903.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. A. Maji, M. Beg, S. Das, N. K. Sahoo, P. K. Jha, M. M. Islam, and M. Hossain (2019). Binding interaction study on human serum albumin with bactericidal gold nanoparticles synthesized from a leaf extract of Musa balbisiana: a multispectroscopic approach. Luminescence 34, 563–575. https://doi.org/10.1002/bio.3639.

    Article  CAS  PubMed  Google Scholar 

  31. M. Majumdar, S. C. Biswas, R. Choudhury, P. Upadhyay, A. Adhikary, D. N. Roy, and T. K. Misra (2019). Synthesis of gold nanoparticles using citrus macroptera fruit extract: anti-biofilm and anticancer activity. ChemistrySelect 4, 5714–5723. https://doi.org/10.1002/slct.201804021.

    Article  CAS  Google Scholar 

  32. I. F. Mosa, M. Youssef, M. Kamel, O. F. Mosa, and Y. Helmy (2019). file:///E:/work/BiM/2.Kidney stone/Kidney stone/10.1152@ajprenal.00199.2019.pdf. Toxicol. Res. (Camb) 8, 939–952. https://doi.org/10.1039/c9tx00221a.

    Article  CAS  PubMed  Google Scholar 

  33. D. M. G. Mosquera, Y. H. Ortega, P. C. Quero, R. S. Martínez, and L. Pieters (2020). Antiurolithiatic activity of Boldoa purpurascens aqueous extract: An in vitro and in vivo study. J. Ethnopharmacol. 253, 112691. https://doi.org/10.1016/j.jep.2020.112691.

    Article  CAS  PubMed  Google Scholar 

  34. A. Muthuvel, K. Adavallan, K. Balamurugan, and N. Krishnakumar (2014). Biosynthesis of gold nanoparticles using Solanum nigrum leaf extract and screening their free radical scavenging and antibacterial properties. Biomed. Prev. Nutr. 4, 325–332. https://doi.org/10.1016/j.bionut.2014.03.004.

    Article  Google Scholar 

  35. M. C. Nirumand, M. Hajialyani, R. Rahimi, M. H. Farzaei, S. Zingue, S. M. Nabavi, and A. Bishayee (2018). Dietary plants for the prevention and management of kidney stones: preclinical and clinical evidence and molecular mechanisms. Int J Mol Sci. https://doi.org/10.3390/ijms19030765.

    Article  PubMed  PubMed Central  Google Scholar 

  36. F. J. Osonga, P. Le, D. Luther, L. Sakhaee, and O. A. Sadik (2018). Water-based synthesis of gold and silver nanoparticles with cuboidal and spherical shapes using luteolin tetraphosphate at room temperature. Environ. Sci. Nano 5, 917–932. https://doi.org/10.1039/c8en00042e.

    Article  CAS  Google Scholar 

  37. P. K. Sarkar and C. Das Mukhopadhyay (2021). Ayurvedic metal nanoparticles could be novel antiviral agents against SARS-CoV-2. Int. Nano Lett. 11, 197–203. https://doi.org/10.1007/s40089-020-00323-9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. T. Selvaraj, A. Thirunavukkarasu, S. M. Rathnavelu, and G. Kasivelu (2019). In vivo non-toxicity of gold nanoparticles on wistar rats. J. Clust. Sci. 30, 513–519. https://doi.org/10.1007/s10876-019-01514-x.

    Article  CAS  Google Scholar 

  39. W. A. Siddiqui, M. Shahzad, A. Shabbir, and A. Ahmad (2018). Evaluation of anti-urolithiatic and diuretic activities of watermelon (Citrullus lanatus) using in vivo and in vitro experiments. Biomed. Pharmacother. 97, 1212–1221. https://doi.org/10.1016/j.biopha.2017.10.162.

    Article  CAS  PubMed  Google Scholar 

  40. B. Stephen Inbaraj and B. H. Chen (2020). An overview on recent in vivo biological application of cerium oxide nanoparticles. Asian J. Pharm. Sci. 15, 558–575. https://doi.org/10.1016/j.ajps.2019.10.005.

    Article  PubMed  Google Scholar 

  41. Y. Sun, J. Kang, Z. Tao, X. Wang, Q. Liu, D. Li, X. Guan, H. Xu, Y. Liu, and Y. Deng (2020). Effect of endoplasmic reticulum stress-mediated excessive autophagy on apoptosis and formation of kidney stones. Life Sci. 244, 117232. https://doi.org/10.1016/j.lfs.2019.117232.

    Article  CAS  PubMed  Google Scholar 

  42. N. Tran, B. Pham, and L. Le (2020). Bioactive compounds in anti-diabetic plants. Biology (Basel) 9, 1–31.

    Google Scholar 

  43. Z. Vahidinia, A. Azami Tameh, M. Nejati, C. Beyer, S. A. Talaei, S. Etehadi Moghadam, and M. A. Atlasi (2019). The protective effect of bone marrow mesenchymal stem cells in a rat model of ischemic stroke via reducing the C-Jun N-terminal kinase expression. Pathol. Res. Pract. 215, 152519. https://doi.org/10.1016/j.prp.2019.152519.

    Article  CAS  PubMed  Google Scholar 

  44. V. Velu, M. Das, N. Raj, and A.N., Dua, K., Malipeddi, H., (2017). Evaluation of in vitro and in vivo anti-urolithiatic activity of silver nanoparticles containing aqueous leaf extract of Tragia involucrata. Drug Deliv. Transl. Res. 7, 439–449. https://doi.org/10.1007/s13346-017-0363-x.

    Article  CAS  PubMed  Google Scholar 

  45. P. Vijaya Kumar, S. Mary Jelastin Kala, and K. S. Prakash (2019). Green synthesis of gold nanoparticles using Croton Caudatus Geisel leaf extract and their biological studies. Mater. Lett. 236, 19–22. https://doi.org/10.1016/j.matlet.2018.10.025.

    Article  CAS  Google Scholar 

  46. W. Wang, X. Wang, X. Zhang, and sheng, Liang, C. zhao, (2018). Cryptotanshinone attenuates oxidative stress and inflammation through the regulation of Nrf-2 and NF-κB in mice with unilateral ureteral obstruction. Basic Clin. Pharmacol. Toxicol. 123, 714–720. https://doi.org/10.1111/bcpt.13091.

    Article  CAS  PubMed  Google Scholar 

  47. J. M. Whittamore and M. Hatch (2017). The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man. Urolithiasis 45, 89–108. https://doi.org/10.1007/s00240-016-0952-z.

    Article  CAS  PubMed  Google Scholar 

  48. M. Xiang, S. Zhang, J. Lu, L. Li, W. Hou, M. Xie, and Y. Zeng (2011). Antilithic effects of extracts from Urtica dentata hand on calcium oxalate urinary stones in rats. J. Huazhong Univ. Sci. Technol. Med. Sci. 31, 673–677. https://doi.org/10.1007/s11596-011-0580-3.

    Article  Google Scholar 

  49. X. Yang, T. Yang, Jie Li, R. Yang, S. Qi, Y. Zhao, L. Li, Jingjin Li, X. Zhang, K. Yang, Y. Xu, and C. Liu (2019). Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo. Int. J. Mol. Med. 43, 1611–1622. https://doi.org/10.3892/ijmm.2019.4084.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. L. Yu, X. Gan, Y. Bai, and R. An (2021). CREB1 protects against the renal injury in a rat model of kidney stone disease and calcium oxalate monohydrate crystals-induced injury in NRK-52E cells. Toxicol. Appl. Pharmacol. 413, 115394. https://doi.org/10.1016/j.taap.2021.115394.

    Article  CAS  PubMed  Google Scholar 

  51. X. Zeng, Y. Xi, and W. Jiang (2019). Protective roles of flavonoids and flavonoid-rich plant extracts against urolithiasis: a review. Crit. Rev. Food Sci. Nutr. 59, 2125–2135. https://doi.org/10.1080/10408398.2018.1439880.

    Article  CAS  PubMed  Google Scholar 

  52. L. Zhao, L. Lu, A. Wang, H. Zhang, M. Huang, H. Wu, B. Xing, Z. Wang, and R. Ji (2020). Nano-biotechnology in agriculture: use of nanomaterials to promote plant growth and stress tolerance. J. Agric. Food Chem. 68, 1935–1947. https://doi.org/10.1021/acs.jafc.9b06615.

    Article  CAS  PubMed  Google Scholar 

  53. W. Zhu, Z. Zhao, F. J. Chou, L. Zuo, T. Liu, D. Bushinsky, C. Chang, G. Zeng, S. Yeh (2019) The protective roles of estrogen receptor β in renal calcium oxalate crystal formation via reducing the liver oxalate biosynthesis and renal oxidative stress-mediated cell injury. Oxid. Med. Cell. Longev. https://doi.org/10.1155/2019/5305014

Download references

Funding

The authors have not disclosed any funding.

Author information

Author notes

  1. Min Bi and Yuying Li have contributed equally to this work.

Authors and Affiliations

  1. Department of Nephrology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China

    Min Bi

  2. Department of Cardiology and Nephrology, The 962 Hospital of PLA joint logistics unit, Harbin, 150080, Heilongjiang, China

    Yuying Li

  3. Department of Hemodialysis, The Railway Central Hospital of Jixi, Jixi, 158100, China

    Fugang Lv

  4. Department of integrated internal medicine, Shanghai Donghai Senior Nursing Hospital Shanghai China, No.8, Lane 5020, SanSan Road, Pudong New Area, Shanghai, 201304, China

    Weiwu Shi

  5. Department of Nephrology, The fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Harbin, 150001, Heilongjiang, China

    Guotao Jiang

Authors
  1. Min Bi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuying Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fugang Lv
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Weiwu Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Guotao Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MB and YL: experimental design, data analysis. FL: data interpretation. WS and GJ: drafted manuscript and principal investigation. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Weiwu Shi or Guotao Jiang.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

Animal experiments were performed in care with the National Research Council (US) Committee for Guide for the Care and Use of Laboratory Animals and all animal experiments were carried out after approval from Institutional animal ethics committee of the fourth Affiliated Hospital of Harbin Medical University, PR China.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bi, M., Li, Y., Lv, F. et al. The Attenuating Effect of Curcumin-Loaded Gold Nanoparticles and Its Combination with Pluchea indica Root Extract on Kidney Stone Induced Male Wistar Rats. J Clust Sci 35, 327–340 (2024). https://doi.org/10.1007/s10876-023-02483-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10876-023-02483-y

Keywords

Search

Navigation