Enhanced Effect of SiC Nanoparticles Combined with Nanohydroxyapatite Material to Stimulate Bone Regenerations in Femoral Fractures Treatment

Abstract

Adequate bone substitute's in osseointegration is not only easy way to achieve osteoporotic. The nano-hydroxyapatite of the osteoporotic bone, covered by osteoblasts, was a lighter in crystal size and smaller crystal phase than conventional materials. Herein, we used materials such as interfacial connection of silicon carbide and hydroxyapatite nanoparticles for osteoporotic study were prepared by electrochemical deposition method. Live/Dead cell assay; the cell viability of SiC@Hydroxyapatite assembly was essentially higher activity than nano-hydroxyapatite. Also, Osteocalcin results, SiC@ Hydroxyapatite 62.33 ± 0.05 (ng/mL) was higher calcin value than nano-hydroxyapatite (39.88 ± 0.12 ng/mL) and silica carbide (15.12 ± 0.04 ng/mL), respectively. Osteoblast cell adhesion, SiC@ Hydroxyapatite motivates a surface-explicit response as a consequence of the hydroxyapatite valuable mineral-based morphological nanostructures. Furthermore, the silica carbide @ nano-hydroxyapatite particles materials shows good biocompatibility, and also the as-synthesized nanomaterial has an excellent developing for osteoporotic and adaptable bone formation in femoral fractures applications.