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RETRACTED ARTICLE: Anticancer Activity of Zn(II) Coordination Polymer Against Cervical Cancer Cells via miR-5571/MDM2

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This article was retracted on 30 January 2024

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Abstract

A fresh mixed-ligand Zn(II) coordination polymer, namely, [Zn2(tbta)(phen)2(OH)]n (1), in which H3tbta is 1-(triazol-1-yl)-2,4,6-benzene tricarboxylic acid and phen is 1,10-phenanthroline, was successfully synthesized through the reaction between H3tbta, a dual-functional ligand, and Zn(NO3)2·6H2O in the presence of the N-donor co-ligand phen. Its anti-cervical cancer activity was evaluated via Cell Counting Kit-8 (CCK-8) assay. Furthermore, they were found to act as tumor suppressor genes that promote tumor cell apoptosis. Finally, their clinical pathological features were observed to be closely related to poor prognosis. miR-5571 was predicted as the upregulator of murine double minute 2 (MDM2) in cervical cancer cells. After transfecting miR-5571, the accumulation of intracellular reactive oxygen species and cell apoptosis in cervical cancer cells were detected and determined using 2,7-Dichlorodihydrofluorescein diacetate (DCFH-DA) and Annexin V-FITC/PI. The direction binding of miR-5571 and MDM2 was proved via luciferase activity detection. This research proved the important role of miR-5571 may help in the further development of better and effective therapeutic approaches for cervical cancer treatment, and the Zn(II) complex could be the excellent candidate for the cervical cancer therapy.

Graphical Abstract

A Zn(II) coordination polymer was synthesized, and its anti-cervical cancer activity was evaluated via Cell Counting Kit-8 (CCK-8) assay. In addition, it was found that this coordination polymer could act as tumor suppressor genes that promote tumor cell apoptosis.

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FT-IR spectra of 1 (Fig. S1), the information could be found in the supporting information file.

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Authors and Affiliations

  1. Department of Medical Genetics, School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, Henan, China

    Hao Liu

  2. Department of Obstetrics and Gynecology, The First Affiliated Hospital of the Military Medical University of the Air Force, Xi’an, Shaanxi, China

    Liying Wu

  3. Department of Medicine, Henan University, Kaifeng, Henan, China

    Jiji Cui & Dan Wang

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  1. Hao Liu
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  2. Liying Wu
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  3. Jiji Cui
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  4. Dan Wang
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Correspondence to Liying Wu.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s10876-024-02574-4

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Liu, H., Wu, L., Cui, J. et al. RETRACTED ARTICLE: Anticancer Activity of Zn(II) Coordination Polymer Against Cervical Cancer Cells via miR-5571/MDM2. J Clust Sci 34, 1195–1206 (2023). https://doi.org/10.1007/s10876-021-02201-6

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  • DOI: https://doi.org/10.1007/s10876-021-02201-6

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