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A new Cu(II)-based coordination polymer: application values on liver cancer through down-regulating relative expression of miRNA9

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Abstract

In current research, a novel coordination polymer based on Cu(II) having a 1D spiro-like chain architecture has been created with the reaction between HL (4-(4-(2-chloroimidazo[1,2-a]pyridin-3-yl)-[2,3′-bipyridin]-6-yl)benzoic acid), the custom designed organic ligand and Cu(NO3)2·3H2O under the reaction conditions of solvothermal, and its chemical formula is [Cu(L)2]·2DMF·3H2O (1). At first, the real-time RT-PCR was accomplished for the determination of the miRNA9 expression level in normal tissue and liver cancer tissue. And the compound’s influence on the miRNA9 relative expression in the cancer cells was next investigated as well. The western blotting assay was in-depth employed for the determination of the PDGF signaling pathway expression in the liver cancer cells after treated with the new compound. In the end, we investigate the direct regulation of miRNA9 on signaling pathway of PDGF by luciferase reporter gene analysis and bioinformatics analysis. Suggested by the simulation of molecular docking, it is found that the carboxyl group of Cu complex could bind to probe protein, at the same time, the pyridine ring also could bind to the probe protein, and therefore suggested that the Cu complex exhibited excellent biological activities.

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References

  1. Gravitz L (2014) Liver cancer. Nature 516:S1

    Article  CAS  Google Scholar 

  2. Anwanwan D, Singh SK, Singh S, Saikam V, Singh R (2020) Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer 1873:188314

    Article  CAS  Google Scholar 

  3. Wang L, Cho KB, Li Y, Tao G, Xie Z, Guo B (2019) Long noncoding RNA (lncRNA)-mediated competing endogenous rna networks provide novel potential biomarkers and therapeutic targets for colorectal cancer. Int J Mol Sci 20:5758

    Article  CAS  Google Scholar 

  4. Vamsikrishna N, Daravath S, Ganji N, Pasha N (2020) Synthesis, structural characterization, DNA interaction, antibacterial and cytotoxicity studies of bivalent transition metal complexes of 6-aminobenzothiazole Schiff base. Inorg Chem Commun 113:107767

    Article  CAS  Google Scholar 

  5. Wang F, Tian F, Deng Y, Yang L, Zhang H, Zhao D, Li B, Zhang X, Fan L (2021) Cluster-based multifunctional Copper(II) organic framework as a photocatalyst in the degradation of organic dye and as an electrocatalyst for overall water splitting. Cryst Growth Des 21:4242–4248

    Article  CAS  Google Scholar 

  6. Fan L, Zhao D, Li B, Wang F, Deng Y, Peng Y, Wang X, Zhang X (2022) Luminescent binuclear Zinc(II) organic framework as bifunctional water-stable chemosensor for efficient detection of antibiotics and Cr(VI) anions in water. Spectrochim Acta A 264:120232

    Article  CAS  Google Scholar 

  7. Li RF, Li RH, Liu XF, Chang XH, Feng X (2020) Lanthanide complexes based on a conjugated pyridine carboxylate ligand: structures, luminescence and magnetic properties. RSC Adv 10:6192–6199

    Article  CAS  Google Scholar 

  8. Li RF, Zhang YW, Liu XF, Chang XH, Feng X (2020) The synthesis, structural elucidation and fluorescent sensitization detection to Hg2+ based on two lanthanide-organic complexes. Inorg Chim Acta 502:119370

    Article  CAS  Google Scholar 

  9. Ma C, Du H, Liu J, Kang L, Du X, Xi X, Ran H (2021) High-temperature stability of dielectric and energy-storage properties of weakly-coupled relaxor (1–x)BaTiO3-xBi(Y1/3Ti1/2)O3 ceramics. Ceram Int 47:25029–25036

    Article  CAS  Google Scholar 

  10. Ran HP, Du HL, Ma CY, Zhao YY, Feng DN, Xu H (2021) Effects of A/B-site co-doping on microstructure and dielectric thermal stability of AgNbO3 ceramics. Sci Adv Mater 13:741–747

    Article  CAS  Google Scholar 

  11. Feng X, Feng YQ, Guo N, Sun YL, Zhang T, Ma LF, Wang LY (2017) Series d−f heteronuclear metal−organic frameworks: color tunability and luminescent probe with switchable properties. Inorg Chem 56:1713–1721

    Article  CAS  Google Scholar 

  12. Feng X, Li RF, Wang LY, Ng SW, Qin GZ, Ma LF (2015) A series of homonuclear lanthanide coordination polymers based on a fluorescent conjugated ligand: syntheses, luminescence and sensor. CrystEngComm 17:7878–7887

    Article  CAS  Google Scholar 

  13. Mahato S, Meheta N, Kotakonda M, Joshi M, Shit M, Choudhury AR, Biswas B (2021) Synthesis, structure, polyphenol oxidase mimicking and bactericidal activity of a zinc-schiff base complex. Polyhedron 194:114933

    Article  CAS  Google Scholar 

  14. Benabid W, Ouari K, Bendia S, Bourzami R, Ali MA (2020) Crystal structure, spectroscopic studies, DFT calculations, cyclic voltammetry and biological activity of a copper (II) Schiff base complex. J Mol Struct 1203:127313

    Article  CAS  Google Scholar 

  15. Razi SS, Koo YH, Kim W, Yang W, Wang Z, Gobeze H, D’Souza F, Zhao J, Kim D (2018) Ping-pong energy transfer in a boron dipyrromethane containing Pt(ii)–schiff base complex: synthesis, photophysical studies, and anti-stokes shift increase in triplet-triplet annihilation upconversion. Inorg Chem 57:4877–4890

    Article  CAS  Google Scholar 

  16. Jagadeesan S, Balasubramanian V, Baumann P, Neuburger M, Häussinger D, Palivan CG (2013) Water-soluble Co(III) complexes of substituted phenanthrolines with cell selective anticancer activity. Inorg Chem 52:12535–12544

    Article  CAS  Google Scholar 

  17. Sukanya P, Reddy CVR (2018) Synthesis, characterization and in vitro anticancer, DNA binding and cleavage studies of Mn (II), Co (II), Ni (II) and Cu (II) complexes of Schiff base ligand 3-(2-(1-(1H-benzimidazol-2-yl)ethylidene)hydrazinyl)quinoxalin-2(1H)-one and crystal structure. Appl Organomet Chem 32:e4526

    Article  Google Scholar 

  18. Raja DS, Bhuvanesh NSP, Natarajan K (2012) A novel water soluble ligand bridged cobalt(ii) coordination polymer of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone: evaluation of the DNA binding, protein interaction, radical scavenging and anticancer activity. Dalt Trans 41:4365–4377

    Article  CAS  Google Scholar 

  19. Shim AHR, Liu H, Focia PJ, Chen X, Lin PC (2010) He X (2010) Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. PNAS 107:11307–11312

    Article  CAS  Google Scholar 

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Author notes

  1. Yun Sun, Dong-Jie Xing contributed equally to this work.

Authors and Affiliations

  1. General Surgery Department, Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China

    Yun Sun

  2. Shandong College of Traditional Chinese Medicine, Yantai, Shandong, China

    Dong-Jie Xing

  3. Nuclear Medicine Department, The 940Th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, China

    Jing-Jun Wei

  4. Department of Medicine, Chongqing Medical University, Chongqing, China

    Wei-Zheng Ding & Shi-Rong Cheng

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  1. Yun Sun
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  2. Dong-Jie Xing
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  3. Jing-Jun Wei
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  4. Wei-Zheng Ding
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  5. Shi-Rong Cheng
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Correspondence to Jing-Jun Wei.

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Sun, Y., Xing, DJ., Wei, JJ. et al. A new Cu(II)-based coordination polymer: application values on liver cancer through down-regulating relative expression of miRNA9. Polym. Bull. 80, 607–619 (2023). https://doi.org/10.1007/s00289-021-04054-5

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  • DOI: https://doi.org/10.1007/s00289-021-04054-5

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