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Fabrication of Gallic Acid Loaded SeNPs and their Neuroprotection Effect for Treatment of Ischemic Stroke

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Abstract

Ischemic stroke (IS) is a usual cerebrovascular ailment having high mortality and morbidity globally. The approaches for the treatment and prevention of cerebral ischemia–reperfusion injury (CIRI) are very limited. In this study, a delivery system of selenium nanoparticles loaded with gallic acid (GA-SeNPs) was developed utilizing ascorbic acid (AA) as a reducing agent and gallic acid (GA) as a capping agent. In pharmacokinetic study, GA-SeNPs clearly increases the AUC of the plasma concentration–time and extended GA half-life. In vitro effects of GA-SeNPs in the middle cerebral artery occlusion (MCAO) model and the oxygen glucose deprivation (OGD) model was measured. Finally, GA-SeNPs can be utilized as an efficient vehicle for delivery of GA in CIRI treatment.

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Authors and Affiliations

  1. Department of Neurosurgery, The First Affiliated Hospital of Airforce Medical University, Xi’an, 710000, Shaanxi, China

    Chao Lv, Yan-Wei Chen, Shu-Hui Dai, Xiao-Fan Jiang & Xia Li

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  1. Chao Lv
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  2. Yan-Wei Chen
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  3. Shu-Hui Dai
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  4. Xiao-Fan Jiang
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  5. Xia Li
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Correspondence to Xia Li.

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Lv, C., Chen, YW., Dai, SH. et al. Fabrication of Gallic Acid Loaded SeNPs and their Neuroprotection Effect for Treatment of Ischemic Stroke. J Clust Sci 33, 1427–1433 (2022). https://doi.org/10.1007/s10876-021-02070-z

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  • DOI: https://doi.org/10.1007/s10876-021-02070-z

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