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Facile Development of Hybrid Bulk-Nanostructured SnSe/SnS for Antibacterial Activity with Negligible Cytotoxicity

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Abstract

The growing appearance of multidrug-resistant bacteria represents one of the greatest challenges in the medical supervision of infectious diseases, and requires the growth of novel antimicrobial agents. Owing to the lower toxicity and cheapness, we have reported facile development of SnS, SnSe and their bulk-nanocomposite (SnSe/SnS) for antimicrobial application. In addition, we have also revealed corresponding hemolytic activities to ensure the effectuality of their antimicrobial capabilities. The antimicrobial properties of SnSe, SnS and SnSe/SnS were studied against Staphylococcus aureus (Gram positive bacteria) and Escherichia coli (Gram negative bacteria), reflecting a considerable control over their growth. SnSe picturized a higher antibacterial potential against the selected bacterial strains as compared to SnS. Notably, SnSe not only exhibited extremely low cytotoxicity itself but it also decreased the cytotoxicity of SnS in SnSe/SnS nanostructure. Relatively lower cytotoxicity of SnSe and SnSe/SnS against erythrocytes affirmed their novel and systematic application as an antimicrobial material compared to SnS.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Institute of Space Technology, Islamabad, 44000, Pakistan

    Allishba Qazi, Madiha Nazir, Sajid Butt & Muhammad Abdul Basit

  2. Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan

    Muhammad Shahid

  3. Department of Materials Science and Chemical Engineering, Hanyang University, Ansan, 15588, Republic of Korea

    Muhammad Abdul Basit

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  1. Allishba Qazi
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  2. Madiha Nazir
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  3. Muhammad Shahid
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  5. Muhammad Abdul Basit
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Correspondence to Sajid Butt or Muhammad Abdul Basit.

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Qazi, A., Nazir, M., Shahid, M. et al. Facile Development of Hybrid Bulk-Nanostructured SnSe/SnS for Antibacterial Activity with Negligible Cytotoxicity. J Clust Sci 32, 665–672 (2021). https://doi.org/10.1007/s10876-020-01824-5

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