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Boron Neutron Capture Therapy Study of 10B Enriched Nanostructured Boron Carbide Against Cervical Cancer and Glioblastoma Cell Line

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Abstract

Boron carbide enriched with 10B isotope (10B4C) was synthesized by simple and low cost solvothermal method. Structural, morphological and optical analysis has been done. Hexagonal phase of the synthesized material show emission in visible region and makes it a promising material for cancer diagnosis. Cytotoxicity analysis has been done to analyze its suitability for biomedical applications. Boron neutron capture therapy (BNCT) has been performed using thermal neutron source in comparison to clinically studied compound on tumor cell lines (HeLa and U-87MG).

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Acknowledgements

This study was funded by the Science and Engineering Research Board (SERB), Department of Science and Technology, India, Project No. EMR/2016/002815.

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Authors and Affiliations

  1. Advanced Functional Materials Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, 140 407, India

    Manjot Kaur, Paviter Singh & Akshay Kumar

  2. Nanotoxicology Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110 067, India

    Ramovatar Meena

  3. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama, 226-8503, Japan

    Fumiko Nakagawa & Hiroyuki Nakamura

  4. Particle Radiation Oncology Research Center Research Reactor Institute, Kyoto University, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, Japan

    Minoru Suzuki

Authors
  1. Manjot Kaur
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  2. Paviter Singh
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  3. Ramovatar Meena
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  4. Fumiko Nakagawa
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  5. Minoru Suzuki
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  6. Hiroyuki Nakamura
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  7. Akshay Kumar
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Correspondence to Akshay Kumar.

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Kaur, M., Singh, P., Meena, R. et al. Boron Neutron Capture Therapy Study of 10B Enriched Nanostructured Boron Carbide Against Cervical Cancer and Glioblastoma Cell Line. J Clust Sci 32, 221–225 (2021). https://doi.org/10.1007/s10876-020-01773-z

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  • DOI: https://doi.org/10.1007/s10876-020-01773-z

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