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Assessment of Sleep Disorders in Patients with CVID

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Abstract

Inborn errors of immunity have been associated with reduced health-related quality of life and increased fatigue. Sleep disorders, which have been shown to contribute to fatigue and other health concerns, are prevalent in the general population, but there are limited studies evaluating these conditions in patients with common variable immunodeficiency (CVID). Our aim was to evaluate the prevalence of fatigue, sleep disturbances, and sleep-disordered breathing in adults with CVID. Patients completed 4 validated, self-administered questionnaires and a 1-night disposable home sleep apnea test. Our results demonstrated increased median Patient-Reported Outcomes Measurement Information System fatigue scores of 58.7 in patients with CVID in addition to clinically significant fatigue as measured by Fatigue Severity Scale score (median, 5.2) and overall poor sleep quality based on global Pittsburgh Sleep Quality Index score (median, 9.0). For CVID patients who completed the home sleep apnea test, 76.9% met criteria for sleep-disordered breathing with an Apnea-Hypopnea Index score of 5 or greater. The results of our study indicate that patients with CVID may have increased rates of undiagnosed sleep disorders that may contribute to increased fatigue and reduced health-related quality of life.

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Data Availability

The additional data that support the findings of this study are available on request from the corresponding author, JDS. The data are not publicly available for the privacy of research participants.

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Funding

This study was supported by an internal grant from the Mayo Clinic Stimulating and Advancing Research in DOM (STARDOM) program. The funding organization had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Author information

Authors and Affiliations

  1. Kadlec Regional Medical Center, Richland, Washington, USA

    Mantavya Punj & Seyed Sina Neshat

  2. Research Fellow in the Division of Pulmonary, Allergy, and Sleep Medicine, Mayo Clinic, Jacksonville, Florida, USA

    Joseph Cheung

  3. Mayo Clinic, Jacksonville, Florida, USA

    Alejandra Yu Lee Mateus

  4. Division of Pulmonary, Allergy, and Sleep Medicine, Mayo Clinic, Jacksonville, FL, USA

    Jacqueline D. Squire

Authors
  1. Mantavya Punj
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  2. Seyed Sina Neshat
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  3. Alejandra Yu Lee Mateus
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  4. Joseph Cheung
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  5. Jacqueline D. Squire
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Contributions

MP contributed to collection, analysis, and interpretation of data; drafting and critical revision of the manuscript; and generation tables. SSN and AYLM contributed to collection of data and critical revision of the manuscript. JC contributed to conception and design, analysis and interpretation of data, and critical revision of the manuscript. JDS contributed to conception and design; collection, analysis, and interpretation of data; and drafting and critical revision of the manuscript. All authors approved the final draft.

Corresponding author

Correspondence to Jacqueline D. Squire.

Ethics declarations

Ethics Approval

This study was approved by the Mayo Clinic Institutional Review Board (IRB 21-008882).

Presented at the Clinical Immunology Society Annual Meeting, St. Louis, Missouri, May 19, 2023.

Consent to Participate

Written patient consent was obtained.

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Not applicable.

Competing Interests

The authors have no relevant financial or non-financial interests to disclose.

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Punj, M., Neshat, S., Mateus, A.L. et al. Assessment of Sleep Disorders in Patients with CVID. J Clin Immunol 44, 109 (2024). https://doi.org/10.1007/s10875-024-01711-y

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  • DOI: https://doi.org/10.1007/s10875-024-01711-y

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