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Hybrid Salt–Cocrystal Solvate: p-Coumaric Acid and Quinine System

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Abstract

A hybrid salt–cocrystal methanol water solvate of p-coumaric acid (p-CA) and quinine (Q) with unexpected stoichiometry was prepared by the slow evaporation technique. The crystals were analysed using single crystal X-ray diffraction. The structure was solved in the monoclinic space group P21 with unit cell dimensions: a = 6.4061(4) Å, b = 26.232(2) Å, c = 10.9639(8) Å and β = 103.707(2)°. The asymmetric unit contains one quininium cation, one p-coumarate anion and one molecule of p-CA, with water and methanol molecules playing a bridging role in the crystal structure. The thermal analyses of the crystals are reported together with kinetics of desolvation for the loss of methanol.

Graphical Abstract

A hybrid salt–cocrystal solvate whereby the asymmetric unit contains one quininium cation, one p-coumarate anion, one molecule of p-coumaric acid, with water and methanol molecules playing a bridging role in the crystal structure.

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Acknowledgments

We thank the Cape Peninsula University of Technology and the National Research Foundation (Pretoria) for funding.

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Authors and Affiliations

  1. Department of Chemistry, Cape Peninsula University of Technology, PO Box 652, Cape Town Campus, Cape Town, 8000, South Africa

    Ayesha Jacobs & Francoise M. Amombo Noa

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  1. Ayesha Jacobs
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  2. Francoise M. Amombo Noa
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Correspondence to Ayesha Jacobs.

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Jacobs, A., Amombo Noa, F.M. Hybrid Salt–Cocrystal Solvate: p-Coumaric Acid and Quinine System. J Chem Crystallogr 44, 57–62 (2014). https://doi.org/10.1007/s10870-013-0480-4

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  • DOI: https://doi.org/10.1007/s10870-013-0480-4

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