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Two Novel Salts of Tris(hydroxymethyl)aminomethane (THAM): Synthesis, Crystal Structure, Thermal and Hirshfeld Surfaces Analysis

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Abstract

The crystals of two organic salts of tris(hydroxymethyl)aminomethane (THAM) with p-hydroxybenzoic acid (PHBA) and salicylic acid (SA) were obtained. Their crystal structures were characterized by single-crystal X-ray diffraction, IR spectra, differential scanning calorimetry, thermogravimetric analyses and hot stage microscopy. Wherein, 1 forms a 1:1 (THAM:PHBA) salt, and 2 forms a 2:2:1 (THAM:SA:H2O) salt. The structure determination shows that the two salts are all primarily stabilized by strong O···H hydrogen bonds interaction between THAM and the two acids. The Hirshfeld surfaces and fingerprint plots of the reported salts were prepared and analyzed and reveal that the structures are stabilized by O···H, H···H, C···H, O···O and O···C intermolecular interactions.

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The paper is about synthesis, crystal structure, thermal and Hirshfeld surfaces analysis of two THAM salts.

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Acknowledgments

This work has been supported by the prospective joint research project of Jiangsu province (BY2012193), Fundamental Research Funds for the Central Universities (CXZZ12 _0119), Natural Science Foundation of China (21371031) and Funds for the Ministry of Science and Technology (212401025).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210096, People’s Republic of China

    Chen-Guang Zhang, Yuan Li, Yang-Hui Luo & Bai-Wang Sun

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  1. Chen-Guang Zhang
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  2. Yuan Li
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  3. Yang-Hui Luo
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  4. Bai-Wang Sun
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Correspondence to Bai-Wang Sun.

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Zhang, CG., Li, Y., Luo, YH. et al. Two Novel Salts of Tris(hydroxymethyl)aminomethane (THAM): Synthesis, Crystal Structure, Thermal and Hirshfeld Surfaces Analysis. J Chem Crystallogr 43, 576–584 (2013). https://doi.org/10.1007/s10870-013-0463-5

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  • DOI: https://doi.org/10.1007/s10870-013-0463-5

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