Skip to main content
SpringerLink
Log in

Synthesis and Crystal Structure of a New Mestranol Acetate

  • Original Paper
  • Published:
Journal of Chemical Crystallography Aims and scope Submit manuscript

Abstract

A new mestranol acetate, 17α-ethinyl-17-hydroxy-3-methoxyestra-1,3,5(10)-triene-6-one-17-acetate, was synthesized by an efficient three-step sequence starting from norethindrone. The structure of the new steroid was characterized by 1H NMR, 13C NMR, MS, IR spectrum and X-ray single crystal diffraction. It crystallizes in the triclinic system, space group P1. The molecules are arranged in a head-to-tail fashion without intra- and intermolecular hydrogen bonding.

Index Abstract

17α-Ethinyl-17-hydroxy-3-methoxyestra-1,3,5(10)-triene-6-one-17-acetate was synthesized and its X-ray single crystal structure showed that the molecules were arranged in a head-to-tail fashion without intra- and intermolecular hydrogen bonding.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Rao PN (1974) Steroids 23:173

    Article  CAS  Google Scholar 

  2. Kazhnitková H, Zamrazilová L, Hill M, Lapčík O, Pouzar V, Hampl R (2007) Steroids 72:342

    Article  Google Scholar 

  3. Jordan VC, Brodie AMH (2007) Steroids 72:7

    Article  CAS  Google Scholar 

  4. Saxena HO, Faridi U, Kumar JK, Luqman S, Darokar MP, Shanker K, Chanotiya CS, Gupta MM, Negi AS (2007) Steroids 72:892

    Article  CAS  Google Scholar 

  5. Li H, Song Y, Peng X (2008) Steroids 73:488

    Article  CAS  Google Scholar 

  6. Li J, Li H, Li Y (2010) Chem Cent J 4:18

    Article  Google Scholar 

  7. Ekhato IV, Hurley T, Lovdahl M, Revitte TJ, Guo L, Huang Y, Clipper S, Colson C (2002) Steroids 67:165

    Article  CAS  Google Scholar 

  8. Bruker (2001) SMART and SAINT. Bruker AXS Inc, Madison

    Google Scholar 

  9. Sheldrick GM (2008) Acta Crystallogr A64:112

    CAS  Google Scholar 

  10. Hofmeister H, Laurent H, Wiechert R (1973) Chem Ber 106:723

    Article  CAS  Google Scholar 

  11. Cotter ML, Levine SD, Mallory R, Shaw C (1978) Tetrahedron Lett (22):1939

  12. Steiner T, Lutz B, van der Maas J, Veldman N, Schreurs AMM, Kroon J, Kanters JA (1997) Chem Commun (2):191

  13. Li H, Song Y, Ge F (2008) Acta Crystallogr E 64:o783

    Article  Google Scholar 

Download references

Acknowledgments

Financial support of the project by Shanghai Natural Science Foundation (No. 06ZR14001) was acknowledged.

Author information

Authors and Affiliations

  1. Key Laboratory of Science & Technology of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 Renmin North Road, Shanghai, 201620, China

    Hongqi Li, Haichuan Qian & Jinxing Li

  2. Faculty of Food Science, College of Life Science and Engineering, Northwest Minorities University, Lanzhou, 730030, China

    Shuwen Ma

Authors
  1. Hongqi Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Haichuan Qian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jinxing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shuwen Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hongqi Li.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, H., Qian, H., Li, J. et al. Synthesis and Crystal Structure of a New Mestranol Acetate. J Chem Crystallogr 41, 1208–1213 (2011). https://doi.org/10.1007/s10870-011-0074-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10870-011-0074-y

Keywords

Search

Navigation