Skip to main content
SpringerLink
Log in

Synthesis, Structure and DNA-Binding Studies of Oxamido-Bridged Binuclear Copper(II) Complex: [Cu2(heap)](bipy)(ClO4)2

  • Original Paper
  • Published:
Journal of Chemical Crystallography Aims and scope Submit manuscript

Abstract

A new μ-oxamido-bridged copper(II)–copper(II) binuclear complex with formula of [Cu2(heap)](bipy)(ClO4)2, where H2heap and bipy are N,N′-bis(N-hydroxyethylaminopropyl)-oxamide and 4,4′-bipyridine, respectively, has been synthesized and characterized by elemental analyses, molar conductivity measurement, IR and electronic spectra studies, and single-crystal X-ray diffraction. The single-crystal X-ray analysis reveals that the complex has two embedded inversion centers at the mid-points of the C6–C6i bond of the oxamido group and the C7–C7ii bond of the 4,4′-bipyridine, respectively [symmetry code: (i) 2−x, 1−y, 1−z; (ii) =2−x, −y, 1−z]. Copper(II) atom is in a square-planar coordination geometry. The Cu···Cu separation through the oxamido birdge is 5.1430(8) Å. The bridging ligand (heap2−) adopts a bis-tetradentate trans conformation. A one-dimensional hydrogen bonding supramolecular structure parallel to the [2 1 0] direction is found in the crystal. The interaction of the binuclear copper(II) complex with herring sperm DNA (HS-DNA) was investigated by using absorption and emission spectra, electrochemical techniques and viscometry. The results suggest that the binuclear copper(II) complex interacts with HS-DNA by electrostatic interaction with intrinsic binding constant of 1.54 × 104 M−1.

Graphical Abstract

A new µ-oxamido-bridged copper(II)–copper(II) binuclear has been synthesized and characterized by single-crystal X-ray diffraction. The interaction of the binuclear copper(II) complex with herring sperm DNA (HS-DNA) was investigated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Chifotides HT, Dunbar KR (2005) Acc Chem Res 38:146

    Article  CAS  Google Scholar 

  2. Bruijinin PC, Sadler PJ (2008) Curr Opin Chem Biol 12:197

    Article  Google Scholar 

  3. Mancin F, Scrimin P, Tacilla P, Tonellato U (2005) J Chem Soc, Chem Commun 28(20):2540

    Google Scholar 

  4. Karlin KD, Tyeklar Z (1993) Bioinorganic Chemistry of Copper. Chapman & Hill, New York

    Google Scholar 

  5. Psomas G (2008) J Inorg Biochem 102:1798

    Article  CAS  Google Scholar 

  6. Efthimiadou EK, Katsaros N, Karaliota A, Psomas G (2007) Inorg Chim Acta 360:4093

    Article  CAS  Google Scholar 

  7. Gupta SK, Hitchcock PB, Kushwah YS, Argal GS (2007) Inorg Chim Acta 360:2145

    Article  CAS  Google Scholar 

  8. Raman N, Jeyamurugan R (2009) J Coord Chem 62:2375

    Article  CAS  Google Scholar 

  9. Jiang M, Li YT, Wu ZY, Liu ZQ, Yan CW (2009) J Inorg Biochem 103:833

    Article  CAS  Google Scholar 

  10. Thomas AM, Neelakanta G, Mahadevan S, Nethaji M, Chakravarty AR (2002) Eur J Inorg Chem 2002(10):2720

    Article  Google Scholar 

  11. Ojima H, Nonoyama K (1988) Coord Chem Rev 92:85

    Article  CAS  Google Scholar 

  12. Sheldrick GM (1997) SHSLXL97, program for crystal structure refinement. University of Göttingen, Germany

    Google Scholar 

  13. Marmur J (1961) J Mol Biol 3:208

    Article  CAS  Google Scholar 

  14. Reichmann ME, Rice SA, Thomas CA, Doty PJ (1954) J Am Chem Soc 76:3047

    Article  CAS  Google Scholar 

  15. Barton JK, Goldberg JM, Kumar CV, Turro NJ (1986) J Am Chem Soc 108:2081

    Article  CAS  Google Scholar 

  16. Chaires JB, Dattagupta N, Crothers DM (1982) Biochemistry 21:3933

    Article  CAS  Google Scholar 

  17. Cohen G, Eisenberg H (1969) Biopolymers 8:45

    Article  CAS  Google Scholar 

  18. Geary WJ (1971) Coord Chem Rev 7:81

    Article  CAS  Google Scholar 

  19. Radecka-Paryzek W (1979) Inorg Chim Acta 34:5

    Article  CAS  Google Scholar 

  20. Tang JK, Yang Y, Zhou HB, Li YZ, Liao DZ, Jiang ZH, Yan SP (2005) Cryst Growth Des 5(2):813

    Article  CAS  Google Scholar 

  21. Cremer D, Pople JA (1975) J Am Chem Soc 97:1354

    Article  CAS  Google Scholar 

  22. Lou JF, Li YT, Wu ZY, Wang DQ, Dou JM (2005) Acta Cryst C61:m400

    CAS  Google Scholar 

  23. Sun F, Li YT, Wu ZY, Song YL, Jiang M (2006) Acta Cryst C62:m584

    CAS  Google Scholar 

  24. Wolf A, Shimer GH Jr, Meehan T (1987) Biochemistry 26:6392

    Article  Google Scholar 

  25. Jiang CW, Chao H, Li H, Ji LN (2003) J Inorg Biochem 93:247

    Article  CAS  Google Scholar 

  26. Pyle AM, Rehmann JP, Meshoyrer R, Kumar CV, Turro NJ, Barton JK (1989) J Am Chem Soc 111:3051

    Article  CAS  Google Scholar 

  27. Le Pecq JB, Paoletti C (1967) J Mol Biol 27:87

    Article  CAS  Google Scholar 

  28. Li JH, Wang JT, Zhang LY, Chen ZN, Mao ZW, Ji LN (2009) J Coord Chem 62(11):1775

    Article  CAS  Google Scholar 

  29. Xiao YN, Zhan CX (2002) J Appl Polym Sci 84:887

    Article  CAS  Google Scholar 

  30. Indumathy R, Radhika S, Kanthimathi M, Weyhermuller T, Nair BU (2007) J Inorg Biochem 101:434

    Article  CAS  Google Scholar 

  31. Stern O, Volmer M (1919) Z Phy 20:183

    CAS  Google Scholar 

  32. Mahadevan S, Palaniandavar M (1998) Inorg Chem 37:693

    Article  CAS  Google Scholar 

  33. Rodriguez M, Bard AJ (1990) Anal Chem 62:2658

    Article  CAS  Google Scholar 

  34. Carter MT, Rodriguez M, Bard AJ (1989) J Am Chem Soc 111:8901

    Article  CAS  Google Scholar 

  35. Carter MT, Bard AJ (1987) J Am Chem Soc 109:7528

    Article  CAS  Google Scholar 

  36. Satyanarayana S, Dabrowiak JC, Chaires JB (1992) Biochemistry 31:9319

    Article  CAS  Google Scholar 

  37. Jin L, Yang P (1997) J Inorg Biochem 68:79

    Article  CAS  Google Scholar 

  38. Li Y, Wu Y, Zhao J, Yang P (2007) J Inorg Biochem 101:283

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This project was supported by the National Natural Science Foundation of China (No. 21071133), and the Natural Science Foundation of Qingdao City (No. 09-1-3-73-jch).

Author information

Authors and Affiliations

  1. Marine Drug and Food Institute, Ocean University of China, 5 Yushan Road, Qingdao, People’s Republic of China

    Yu Yu & Yan-Tuan Li

  2. Key Laboratory of Marine Drug, Chinese Ministry of Education, Ocean University of China, Qingdao, People’s Republic of China

    Xiao-Wen Li, Lu-Yan Jiang & Zhi-Yong Wu

  3. College of Marine Life Science, Ocean University of China, Qingdao, 266003, People’s Republic of China

    Cui-Wei Yan

Authors
  1. Yu Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiao-Wen Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lu-Yan Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yan-Tuan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhi-Yong Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Cui-Wei Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yan-Tuan Li or Cui-Wei Yan.

Additional information

Yu Yu and Xiao-Wen Li contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yu, Y., Li, XW., Jiang, LY. et al. Synthesis, Structure and DNA-Binding Studies of Oxamido-Bridged Binuclear Copper(II) Complex: [Cu2(heap)](bipy)(ClO4)2 . J Chem Crystallogr 41, 959–965 (2011). https://doi.org/10.1007/s10870-011-0025-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10870-011-0025-7

Keywords

Search

Navigation