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Three dimensional printed bioglass/gelatin/alginate composite scaffolds with promoted mechanical strength, biomineralization, cell responses and osteogenesis

  • Special Issue: CESB 2019
  • Original Research
  • Published:
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Abstract

In this study, porous bioglass/gelatin/alginate bone tissue engineering scaffolds were fabricated by three-dimensional printing. The compressive strength and in vitro biomineralization properties of the bioglass–gelatin–alginate scaffolds (BG/Gel/SA scaffolds) were significantly improved with the increase of bioglass content until 30% weight percentage followed by a rapid decline in strength. In addition, the cells attach and spread on the BG/Gel/SA scaffolds surfaces represents good adhesion and biocompatibility. Furthermore, the cells (rat bone marrow mesenchymal stem cells, mBMSCs) proliferation and osteogenic differentiation on the BG/Gel/SA scaffolds were also promoted with the increase of bioglass content. Overall, the adding of bioglass in Gel/SA scaffolds promotes mechanical strength and in vitro osteogenic properties and the 30 BG scaffold (30%wt BG) has potential applications in bone tissue engineering and bone regenerative repair because of good compressive strength, biocompatibility, and in vitro osteogenesis.

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Funding

The authors funding support from the National Nature Science Foundation of China (31500762), Guangdong Science and Technology Program (2014B010133001, 2016A010103009), National key research and development plan project (2016YFC1100600).

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Author notes

  1. These authors contributed equally: Qing Ye, Ying Zhang

Authors and Affiliations

  1. School of Material Science and Engineering, South China University of Technology, 510641, Guangzhou, PR China

    Qing Ye & Fei Hang

  2. National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, 510006, Guangzhou, PR China

    Qing Ye, Ying Zhang, Kun Dai & Lei Zeng

  3. Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, 510006, Guangzhou, PR China

    Qing Ye, Kun Dai & Xiaofeng Chen

  4. Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, 510006, Guangzhou, PR China

    Ying Zhang & Lei Zeng

  5. School of Biomedical Science and Engineering, South China University of Technology, Guangzhou International Campus, 510641, Guangzhou, PR China

    Xiaofeng Chen

  6. School of Engineering, University of Glasgow, Scotland, G11 6BZ, UK

    Hannah Mae Read

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  1. Qing Ye
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Correspondence to Lei Zeng or Fei Hang.

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Ye, Q., Zhang, Y., Dai, K. et al. Three dimensional printed bioglass/gelatin/alginate composite scaffolds with promoted mechanical strength, biomineralization, cell responses and osteogenesis. J Mater Sci: Mater Med 31, 77 (2020). https://doi.org/10.1007/s10856-020-06413-6

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  • DOI: https://doi.org/10.1007/s10856-020-06413-6

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