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Bioactivity evaluation of collagen-based scaffolds containing a series of Sr-doped melt-quench derived phosphate-based glasses

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

Phosphate-based glasses have been attracting attention due to their possible medical applications arising from unique dissolution characteristics in the human body leading to the possibility of new tissue regeneration. In this study, the leaching kinetics of a series of melt-quenched Sr-doped phosphate glasses are presented. Regardless of the presence of Sr, all the glasses have an initial linear and sustained release of the ions followed by a plateau. To guarantee proper nutritional support to the growing tissue during regeneration and to mimic the 3-dimensional architecture of tissues, organic scaffold systems have been developed. However, their poor mechanical strength has limited their application. To overcome this problem, cross-linkers can be used although this then limits the solubility of the materials. To succeed in dealing with such a limitation, in this paper, by freeze-drying, the aforementioned soluble melt-quenched phosphate glasses were combined as powders with collagen fibres from bovine achilles tendon to make degradable scaffolds. The scaffolds were characterized by SEM, EDX and BET. Changes to the dissolution behaviour of the glasses arising from the presence of collagen interacting with the ions leached were reported. Furthermore, the ability of the scaffolds to induce hydroxyapatite (HA) formation was evaluated: one the elaborated scaffold could grow an HA-like layer after a week in SBF. Based on the results obtained, a possible application in restorative dentistry is proposed for one or more materials.

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Acknowledgements

The research leading to this article has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement no 608197. In addition, I would like to thank all the Lucideon’s staff for performing some tests described in this paper and for their help and support in discussing and interpreting the results.

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Authors and Affiliations

  1. Université Claude Bernard Lyon 1, CNRS, Laboratoire des Multimatériaux et Interfaces, Université Lyon, Villeurbanne, France

    Vincenzo Farano, Kerstin Gritsch, Brigitte Grosgogeat & Jean-Christophe Maurin

  2. Faculté d’Odontologie, Université Claude Bernard Lyon 1, Lyon, France

    Vincenzo Farano, Kerstin Gritsch, Nina Attik, Brigitte Grosgogeat & Jean-Christophe Maurin

  3. Lucideon Limited, Queens Road, Penkhull, Stoke-on-Trent, Staffordshire, ST4 7LQ, UK

    Mark Cresswell & Phil Jackson

  4. Service d’Odontologie, Hospices Civils de Lyon, Lyon, France

    Kerstin Gritsch, Brigitte Grosgogeat & Jean-Christophe Maurin

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  1. Vincenzo Farano
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  2. Mark Cresswell
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Correspondence to Jean-Christophe Maurin.

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Farano, V., Cresswell, M., Gritsch, K. et al. Bioactivity evaluation of collagen-based scaffolds containing a series of Sr-doped melt-quench derived phosphate-based glasses. J Mater Sci: Mater Med 29, 101 (2018). https://doi.org/10.1007/s10856-018-6110-0

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  • DOI: https://doi.org/10.1007/s10856-018-6110-0

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