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Fabrication of transparent quaternized PVA/silver nanocomposite hydrogel and its evaluation as an antimicrobial patch for wound care systems

  • Engineering and Nano-engineering Approaches for Medical Devices
  • Original Research
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Abstract

Grafting of quaternary nitrogen atoms into the backbone of polymer is an efficient way of developing new generation antimicrobial polymeric wound dressing. In this study, an elastic, non-adhesive and antimicrobial transparent hydrogel based dressing has been designed, which might be helpful for routine observation of wound area without removing the dressing material along with maintaining a sterile environment for a longer period of time. Green synthesized silver nanoparticles have been loaded into the quaternized PVA hydrogel matrix to improve its antimicrobial property. Silver nanoparticles loaded quaternized PVA hydrogel showed enhanced mechanical and swelling properties compared to native quaternized PVA hydrogel. Release kinetics evaluated by atomic absorption spectroscopy revealed that the release mechanism of silver nanoparticles from the hydrogel follows Fickian diffusion. Antimicrobial efficacy of the hydrogels was evaluated by disk diffusion test on Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli. After 96 h of release in phosphate buffer, the growth inhibition zone created by silver nanoparticless loaded quaternized PVA hydrogel is comparable to that created by ampicillin. These observations assert that the silver nanoparticles loaded quaternized PVA hydrogel acts as a reservoir of silver nanoparticles, which helps in maintaining a sterile environment for longer time duration by releasing Ag nanocrystallite in sustained manner.

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Acknowledgments

The authors acknowledge IIT Delhi for the financial support

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Authors and Affiliations

  1. Max Bergmann Center of Biomaterials, Technische Universität Dresden, Budapester Straße 27, Dresden, 01069, Germany

    Sirsendu Bhowmick

  2. Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India

    Sirsendu Bhowmick & Veena Koul

  3. Biomedical Engineering Unit, All India Institute of Medical Sciences, New Delhi, 110029, India

    Sirsendu Bhowmick & Veena Koul

  4. Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, 110029, India

    Sujata Mohanty

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  1. Sirsendu Bhowmick
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Correspondence to Veena Koul.

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Bhowmick, S., Mohanty, S. & Koul, V. Fabrication of transparent quaternized PVA/silver nanocomposite hydrogel and its evaluation as an antimicrobial patch for wound care systems. J Mater Sci: Mater Med 27, 160 (2016). https://doi.org/10.1007/s10856-016-5772-8

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