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Prolongation of the degradation period and improvement of the angiogenesis of zein porous scaffolds in vivo

  • Tissue Engineering Constructs and Cell Substrates
  • Original Research
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Abstract

Zein porous scaffolds modified with fatty acids have shown great improvement in mechanical properties and good cell compatibility in vitro, indicating the potential application as a bone tissue engineering substitute. The present study was conducted to systematically investigate whether the addition of fatty acids affects the short-term (up to 12 weeks) and long-term (up to 1 year) behaviors of scaffolds in vivo, mainly focusing on changes in the degradation period and inflammatory responses. Throughout the implantation period, no abnormal signs occurred and zein porous scaffolds modified with oleic acid showed good tolerance in rabbits, characterized by the growth of relatively more blood vessels in the scaffolds and only a slight degree of fibrosis histology. Moreover, the degradation period was prolonged from 8 months to 1 year as compared to the control. These results affirmed further that zein could be used as a new kind of natural biomaterial suitable for bone tissue engineering.

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Acknowledgments

The authors gratefully acknowledge the financial support provided by the International S&T Cooperation Program of China (2012DFA30270, 2015DFG32730), the Shanghai Municipal Science and Technology Commission (12JC1403400, 15540723900).

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Author notes

  1. Hua-Jie Wang

    Present address: Center for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou, 451191, P.R. China

Authors and Affiliations

  1. School of Biomedical Engineering, Shanghai Jiao Tong University, Dongchuan Road, Shanghai, 200240, China

    Hua-Jie Wang & Jin-Ye Wang

  2. Key Lab of Biological Evaluation of Medical Devices, Shandong Quality Inspection Center for Medical Devices, Jinan, 250101, Shandong, China

    Jing-Chun Huang & Li Hou

  3. Food Biotechnology Innovation Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai, 980-0845, Japan

    Teruo Miyazawa

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  1. Hua-Jie Wang
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Correspondence to Jin-Ye Wang.

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Wang, HJ., Huang, JC., Hou, L. et al. Prolongation of the degradation period and improvement of the angiogenesis of zein porous scaffolds in vivo. J Mater Sci: Mater Med 27, 92 (2016). https://doi.org/10.1007/s10856-016-5697-2

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  • DOI: https://doi.org/10.1007/s10856-016-5697-2

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