Skip to main content
SpringerLink
Log in

Technique to optimize magnetic response of gelatin coated magnetic nanoparticles

  • Biomaterials Synthesis and Characterization
  • Original Research
  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

The paper describes the results of optimization of magnetic response for highly stable bio-functionalize magnetic nanoparticles dispersion. Concentration of gelatin during in situ co-precipitation synthesis was varied from 8, 23 and 48 mg/mL to optimize magnetic properties. This variation results in a change in crystallite size from 10.3 to 7.8 ± 0.1 nm. TEM measurement of G3 sample shows highly crystalline spherical nanoparticles with a mean diameter of 7.2 ± 0.2 nm and diameter distribution (σ) of 0.27. FTIR spectra shows a shift of 22 cm−1 at C=O stretching with absence of N–H stretching confirming the chemical binding of gelatin on magnetic nanoparticles. The concept of lone pair electron of the amide group explains the mechanism of binding. TGA shows 32.8–25.2 % weight loss at 350 °C temperature substantiating decomposition of chemically bind gelatin. The magnetic response shows that for 8 mg/mL concentration of gelatin, the initial susceptibility and saturation magnetization is the maximum. The cytotoxicity of G3 sample was assessed in Normal Rat Kidney Epithelial Cells (NRK Line) by MTT assay. Results show an increase in viability for all concentrations, the indicative probability of a stimulating action of these particles in the nontoxic range. This shows the potential of this technique for biological applications as the coated particles are (i) superparamagnetic (ii) highly stable in physiological media (iii) possibility of attaching other drug with free functional group of gelatin and (iv) non-toxic.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Pankhurst QA, Connolly J, Jones SK, Dobson J. Applications of magnetic nanoparticles in biomedicine. J Phys D. 2003;36:R167–81.

    Article  Google Scholar 

  2. Dobson J. Magnetic nanoparticles for drug delivery. Drug Dev Res. 2006;67:55–60.

    Article  Google Scholar 

  3. Gupta AK, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials. 2005;26:3995–4021.

    Article  Google Scholar 

  4. Arruebo M, Fernández-Pacheco R, Ricardo Ibarra M, Santamaría J. Magnetic nanoparticles for drug delivery. Nanotoday. 2007;2:22–32.

    Article  Google Scholar 

  5. Krishnan Kannan M. Biomedical nanomagnetics: a spin through possibilities in imaging, diagnostics, and therapy. IEEE Trans Magn. 2010;46:2523–58.

    Article  Google Scholar 

  6. Kumar RV, Koltypin Y, Cohen YS, Cohen Y, Aurbach D, Palchik O, Felner I, Gedanken A. Preparation of amorphous magnetite nanoparticles embedded in polyvinyl alcohol using ultrasound radiation. J Mater Chem. 2000;10:1125–9.

    Article  Google Scholar 

  7. Bychkova AV, Sorokina ON, Rosenfeld MA, Kovarski AL. Multifunctional biocompatible coatings on magnetic nanoparticles. Russ Chem Rev. 2012;81:1026–50.

    Article  Google Scholar 

  8. Guannan W, Xingguang S. The synthesis and bio-applications of magnetic and fluorescent bifunctional composite nanoparticles. Analyst. 2011;136:1783–98.

    Article  Google Scholar 

  9. Bao G, Mitragotri S, Tong S. Multifunctional nanoparticles for drug delivery and molecular imaging. Annu Rev Biomed Eng. 2013;15:253–82.

    Article  Google Scholar 

  10. Koffie RM, Farrar CT, Saidi L, William CM, Hyman BT, Spires-Jones TL. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proc Natl Acad Sci. 2011;46:18837–42.

    Article  Google Scholar 

  11. Xu H, Yan F, Monson EE, Kopelman R. Room‐temperature preparation and characterization of poly (ethylene glycol)‐coated silica nanoparticles for biomedical applications. J Biomed Mater Res. 2003;66(4):870–9.

    Article  Google Scholar 

  12. Sell SA, Wolfe PS, Garg K, McCool JM, Rodriguez IA, Bowlin GL. The use of natural polymers in tissue engineering: a focus on electrospun extracellular matrix analogues. Polymers. 2010;2:522–33.

    Article  Google Scholar 

  13. Samal SK, Dash M, Vlierberghe SV, Kalpan DL, Chiellini E, van Blitterswijk C, Moroni L, Dubreul P. Cationic polymers and their therapeutic potential. Chem Soc Rev. 2012;41:7147–94.

    Article  Google Scholar 

  14. Cordente N, Respaud M, Senocq F, Casanove M-J, Amiens C, Chaudret B. Synthesis and magnetic properties of nickel nanorods. Nano Lett. 2001;1(10):565–8.

    Article  Google Scholar 

  15. Gaihre B, Khil MS, Kang HK, Kim HY. Bioactivity of gelatin coated magnetic iron oxide nanoparticles: in vitro evaluation. J Mater Sci. 2009;20:573–81.

    Google Scholar 

  16. Young S, Wong M, Tabata Y, Mikos AG. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release. 2005;109:256–74.

    Article  Google Scholar 

  17. Ziv O, Avtailion R, Margel S. Immunogenicity of bioactive magnetic nanoparticles: natural and acquired antibodies. J Biomed Mater Res Part A. 2008;85:1011–21.

    Article  Google Scholar 

  18. Chen G, Qiao C, Wang Y, Yao J. Synthesis of magnetic gelatin and its adsorption property for Cr (VI). Ind Eng Chem Res. 2014;53(40):15576–81.

    Article  Google Scholar 

  19. Allouche J, Chanéac C, Brayner R, Boissière M, Coradin T. Design of magnetic gelatine/silica nanocomposites by nanoemulsification: encapsulation versus in situ growth of iron oxide colloids. Nanomaterials. 2014;4:612–27.

    Article  Google Scholar 

  20. Gaihre B, Khil MS, Ko JA, Kim HY. Techniques of controlling hydrodynamic size of ferrofluid of gelatin-coated magnetic iron oxide nanoparticles. J Mater Sci. 2008;43:6881–9.

    Article  Google Scholar 

  21. Giorgio B. Hysteresis in magnetism, for physicist, material scientists and engineers. San Diego: Academy Press; 1998. p. 317.

    Google Scholar 

  22. Parekh Kinnari. Effect of preparative conditions on magnetic properties of CoFe (2) O (4) nanoparticles. Indian J Pure Appl Phys. 2010;48:581.

    Google Scholar 

  23. Jiles D. Introduction to magnetism and magnetic materials. London: Chapman & Hall publisher; 1991.

    Book  Google Scholar 

Download references

Acknowledgments

Authors would like to thank DST, Govt. of India for providing financial support to NP under technology development project No. 161-G.

Author information

Authors and Affiliations

  1. Dr. K C Patel R & D Center, Charotar University of Science & Technology, Dist. Anand, Changa, 388 421, India

    Nidhi Parikh & Kinnari Parekh

Authors
  1. Nidhi Parikh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kinnari Parekh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kinnari Parekh.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Parikh, N., Parekh, K. Technique to optimize magnetic response of gelatin coated magnetic nanoparticles. J Mater Sci: Mater Med 26, 202 (2015). https://doi.org/10.1007/s10856-015-5534-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10856-015-5534-z

Keywords

Search

Navigation