Abstract
In this study, magnetic iron oxide (IOPs) nanoparticles were coated with gelatin B, and various parameters were investigated to find out effects of those parameters in the overall hydrodynamic size of the colloidal dispersions. Two different types of coating techniques, viz., in situ and separately precipitation/coating technique were investigated. In in situ precipitation/coating technique, precipitation, and coating of the IOPs were done simultaneously, while in separately precipitation/coating technique, the IOPs particles were separately precipitated and purified before surface coating was done. The colloidal dispersion obtained from these two methods showed drastically different viscosities as well as hydrodynamic size. It was found that in situ precipitation/coating technique gave smaller-sized monodispersed particles compare to separately precipitation/coating technique. In addition to the above two techniques, the desolvation/cross-linking technique was also investigated and found to, further, reduce the size of the ferrofluid prepared by the in situ and separately precipitation/coating techniques. The ferrofluids prepared using in situ as well as separately precipitation techniques were highly stable and did not sediment for more than 1 month. However, the desolvation/cross-linking technique gave dispersion with reduced stability. Nevertheless, by adjusting suitable combination of acetone and glyceraldehydes, ferrofluid with better stability could be produced by this technique.
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Gupta AK, Gupta M (2005) Biomaterials 26:3995. doi:https://doi.org/10.1016/j.biomaterials.2004.10.012
Tiraferri A, Chen KL, Sethi R, Elimelech M (2008) J Colloid Interface Sci 324:71. doi:https://doi.org/10.1016/j.jcis.2008.04.064
Saravanan M, Bhaskar K, Maharajan G, Pillai KS (2004) Int J Pharm 283:71. doi:https://doi.org/10.1016/j.ijpharm.2004.06.023
Young S, Wong M, Tabata Y, Mikos AG (2005) J Control Release 109:256. doi:https://doi.org/10.1016/j.jconrel.2005.09.023
Coester C, Nayyar P, Samuel J (2006) Eur J Pharm Biopharm 62:306. doi:https://doi.org/10.1016/j.ejpb.2005.09.009
Gaihre B, Parajuli DC, Seo HC, Khil MS, Kim HY (2008) Adsorpt Sci Technol (in press).
Gaihre B, Aryal S, Khil MS, Kim HY (2008) J Microencapsul 25:21. doi:https://doi.org/10.1080/02652040701737697
Gaihre B, Khil MS, Kang HK, Kim HY (2008) J Mater Sci: Mater Med (in press)
Berry CC (2004) J Mater Chem 15:543. doi:https://doi.org/10.1039/b409715g
Zhang JL, Srivastava RS, Misra RDK (2007) Langmuir 23:6342. doi:https://doi.org/10.1021/la0636199
Zhang Y, Kohler N, Zhang M (2002) Biomaterials 23:1553. doi:https://doi.org/10.1016/S0142-9612(01)00267-8
Harris LA, Goff JD, Carmichael AY, Riffle JS, Harburn JJ, Pierre TGS et al (2003) Chem Mater 15:1367. doi:https://doi.org/10.1021/cm020994n
Bourlinos AB, Bakandritsos A, Georgakilas V, Petridis D (2000) Chem Mater 14:3226. doi:https://doi.org/10.1021/cm020404l
Loeb J (1924) Proteins and the theory of colloidal behavior. McGraw-Hill, New York
Kunitz M (1927) J Gen Physiol 10:811. doi:https://doi.org/10.1085/jgp.10.5.811
Northrop JH (1928) J Gen Physiol 12:529. doi:https://doi.org/10.1085/jgp.12.4.529
Kamyshny A, Toledano O, Magdassi S (1999) Colloids Surf B Biointerfaces 13:187. doi:https://doi.org/10.1016/S0927-7765(99)00012-0
Bele M, Gaberscek M, Dominko R, Drofenik J, Zupan K, Komac P et al (2002) Carbon 40:1117. doi:https://doi.org/10.1016/S0008-6223(01)00257-3
Hone JHE, Howe AM, Whitesides TH (2000) Colloids Surf A Physicochem Eng Asp 161:283. doi:https://doi.org/10.1016/S0927-7757(99)00377-5
Leo E, Vandelli MA, Cameroni R, Forni F (1997) Int J Pharm 155:75. doi:https://doi.org/10.1016/S0378-5173(97)00149-X
Shirad A, Huang Y, Chen H, McQuarrie S, Abrams D, Rao W et al (2006) J Pharm Pharm Sci 9:124
Alma JK, Gerard HME, Jeroen K, Sebastian AJZ, Jacob D, Jan F (1999) J Biomater Sci Polym Ed 11:225
Cornell RM, Schwertmann U (2000) The iron oxides. Wiley, Weinheim, Germany
Illes E, Tombacz E (2006) J Colloid Interface Sci 295:115. doi:https://doi.org/10.1016/j.jcis.2005.08.003
Acknowledgements
This research was supported by the Regional Research Center Program of the Korean Ministry of Education (KRF-2005-211-D00054) and Korean Research Foundation Grant Funded by the Korean Government (MOEHRD) the center for Healthcare Technology Development, Jeonju 561–756, Republic of Korea.
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Gaihre, B., Khil, M.S., Ko, J.A. et al. Techniques of controlling hydrodynamic size of ferrofluid of gelatin-coated magnetic iron oxide nanoparticles. J Mater Sci 43, 6881–6889 (2008). https://doi.org/10.1007/s10853-008-3003-5
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DOI: https://doi.org/10.1007/s10853-008-3003-5