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Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel

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Abstract

The drug release characteristics of calcium alginate hydrogels, (Ca-Alg), under an electric field assisted transdermal drug delivery system were systematically investigated. The Ca-Alg hydrogels were prepared by the solution-casting using CaCl2 as a crosslinking agent. The diffusion coefficients and the release mechanism of the anionic model drugs, benzoic acid and tannic acid, and a cationic model drug, folic acid on the Ca-Alg hydrogels were determined and investigated using a modified Franz-Diffusion cell in an MES buffer solution of pH 5.5, at a temperature of 37°C, for 48 h. The influences of the crosslinking ratio, —the mole of the crosslinking agent to the mole of the alginate monomer—mesh size, model drug size, drug charge, electric field strength, and electrode polarity were systematically studied. The drug diffusion coefficient decreased with an increasing crosslinking ratio and drug size for all of the model drugs. The drug diffusion coefficient is precisely controlled by an applied electric field and the electrode polarity depending on the drug charge, suitable for a tailor-made transdermal drug delivery system.

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Acknowledgment

The authors wish to express their thanks for the financial support provided by the Thailand Research Fund (RGJ PHD/0285/2551, and BRG), the Conductive and Electroactive Polymer Research Unit of Chulalongkorn University, the Royal Thai Government, and the Petroleum Petrochemical and Advanced Materials Consortium.

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Authors and Affiliations

  1. Conductive and Electroactive Polymers Research Unit, The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, 10330, Thailand

    Nophawan Paradee & Anuvat Sirivat

  2. Department of Materials and Metallurgical Engineering, Faculty of Engineering, Rajamangala University of Technology Thanyaburi, Klong 6, Pathumthani, 12110, Thailand

    Sumonman Niamlang

  3. Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok, 10800, Thailand

    Walaiporn Prissanaroon-Ouajai

Authors
  1. Nophawan Paradee
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  2. Anuvat Sirivat
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  3. Sumonman Niamlang
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  4. Walaiporn Prissanaroon-Ouajai
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Correspondence to Anuvat Sirivat.

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Paradee, N., Sirivat, A., Niamlang, S. et al. Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel. J Mater Sci: Mater Med 23, 999–1010 (2012). https://doi.org/10.1007/s10856-012-4571-0

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  • DOI: https://doi.org/10.1007/s10856-012-4571-0

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