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Application of K/Sr co-doped calcium polyphosphate bioceramic as scaffolds for bone substitutes

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Abstract

Ion doping is one of the most important methods to modify the properties of bioceramics for better biodegrade abilities, biomechanical properties, and biocompatibilities. This paper presents a novel ion doping method applied in calcium polyphosphate (CPP)-based bioceramic scaffolds substituted by potassium and strontium ions (K/Sr) to form (K/Sr–CPP) scaffolds for bone tissue regeneration. The microstructure and crystallization of the scaffolds were detected by scanning electron microscopy and X-ray diffraction. Compressive strength and degradation tests were assessed to evaluate the mechanical and chemical stabilities of K/Sr–CPP in vitro. The cell biocompatibility was measured with respect to the cytotoxicity of the extractions of scaffolds. Muscle pouches and bone implantation were performed to evaluate the biodegradability and osteoconductivity of the scaffolds. The results indicated that the obtained K/Sr–CPP scaffolds had a single beta-CPP phase. The unit cell volume and average grain size increased but the crystallization decreased after the ions were doped into the CPP structure. The K/Sr–CPP scaffolds yielded a higher compressive strength and a better degradation property than the pure CPP scaffold. The MTT assay and in vivo results reveal that the K/Sr–CPP scaffolds exhibited a better cell biocompatibility and a tissue biocompatibility than CPP and hydroxyapatite scaffolds. This study proves the potential applications of K/Sr–CPP scaffolds in bone repair.

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Acknowledgment

The authors would like to acknowledge NSFC Grant No.30870614 for its support to this project. They wish to thank the Centre of Analysis and Testing of Sichuan University for SEM and XRD measurements.

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Authors and Affiliations

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610061, People’s Republic of China

    Huixu Xie, Qingsong Ye & Longjiang Li

  2. Department of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, People’s Republic of China

    Changxiu Wan

  3. School of Chemistry and Environment, Beihang University, Beijing, 100191, People’s Republic of China

    Qianbin Wang

  4. Department of Orthodontics, School of Medicine and Dentistry, James Cook University, Cairns, QLD, 4878, Australia

    Qingsong Ye

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  1. Huixu Xie
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  2. Qianbin Wang
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  3. Qingsong Ye
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  4. Changxiu Wan
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  5. Longjiang Li
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Corresponding author

Correspondence to Longjiang Li.

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Huixu Xie and Qianbin Wang contributed equally to this work.

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Xie, H., Wang, Q., Ye, Q. et al. Application of K/Sr co-doped calcium polyphosphate bioceramic as scaffolds for bone substitutes. J Mater Sci: Mater Med 23, 1033–1044 (2012). https://doi.org/10.1007/s10856-012-4556-z

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  • DOI: https://doi.org/10.1007/s10856-012-4556-z

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