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Novel production method of porous surface Ti samples for biomedical application

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Abstract

A porous implant material with adequate pore structure and the appropriate mechanical properties for bone ingrowth has long been sought. This article presents details of the development, characterization and in vivo evaluations of powder metallurgy-processed titanium samples exhibiting a dense core with an integrated porous surface for biomedical applications. A space-holder method was applied to investigate the effects of different percentages and particle sizes of the urea on bone neoformation in 30 rabbits. The samples were previously characterized using scanning electron microscopy and mechanical testing. After 8 and 12 weeks of implantation, bone ingrowth was histologically and histometrically analyzed and push-out testing was performed. This study demonstrated that the association of a dense core integrated with the greatest number of interconnected pores of the smallest size is a promising biomaterial for bone tissue engineering. This sample exhibits appropriate mechanical properties combined with increased bone ingrowth, providing enhanced resistance to displacement.

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Acknowledgment

This study was supported by research grant 2005/03709-4, awarded by the State of São Paulo Research (FAPESP), Brazil.

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Authors and Affiliations

  1. Department of Bioscience and Oral Diagnosis, São Jose dos Campos School of Dentistry, Universidade Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777 Jd. São Dimas, São José dos Campos, SP, 12245-000, Brazil

    Luana Marotta Reis de Vasconcellos, Fernanda Nascimento Oliveira, Daniel de Oliveira Leite, Luis Gustavo Oliveira de Vasconcellos, Renata Falchete do Prado, Carolina Judica Ramos, Carlos Alberto Alves Cairo & Yasmin Rodarte Carvalho

  2. Division of Materials, Air and Space Institute, CTA, Praça Mal. do Ar Eduardo Gomes, 14, São José dos Campos, SP, 12904-000, Brazil

    Mário Lima de Alencastro Graça

Authors
  1. Luana Marotta Reis de Vasconcellos
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  2. Fernanda Nascimento Oliveira
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  3. Daniel de Oliveira Leite
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  4. Luis Gustavo Oliveira de Vasconcellos
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  5. Renata Falchete do Prado
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  6. Carolina Judica Ramos
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  7. Mário Lima de Alencastro Graça
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  8. Carlos Alberto Alves Cairo
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  9. Yasmin Rodarte Carvalho
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Correspondence to Luana Marotta Reis de Vasconcellos.

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Vasconcellos, L.M.R., Oliveira, F.N., Leite, D.O. et al. Novel production method of porous surface Ti samples for biomedical application. J Mater Sci: Mater Med 23, 357–364 (2012). https://doi.org/10.1007/s10856-011-4515-0

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  • DOI: https://doi.org/10.1007/s10856-011-4515-0

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