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In vitro release kinetics and physical, chemical and mechanical characterization of a POVIAC ® /CaCO 3 /HAP-200 composite

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Abstract

Coralline calcium-hydroxyapatite and calcium carbonate from Porites Porites coral were added to a polymeric matrix based on polyvinyl acetate (POVIAC®), to obtain a novel bone substitute composite as well as a system for the controlled drug (cephalexin) release. Composite samples with different compositions were characterized by physical–chemical and mechanical methods. Furthermore, the in vitro release profile of cephalexin and the kinetic behavior of its release from these composites were analyzed by appropriate mathematical models. It was shown that there is no chemical interaction between the inorganic filler and the polymer matrix, each conserving the original properties of the raw materials. The compressive mechanical strength and Young modulus of the composite with 17.5% of POVIAC®, has better mechanical properties than those of cancellous bone. The variation of POVIAC® content can affect the cephalexin release kinetic in the composite. The cephalexin release mechanism from the composites can be considered as the result of the joint contribution of a prevailing Fickian diffusion and of polymer chain relaxation. It was also demonstrated that cephalexin is occluded inside the composites and not on their surface.

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Acknowledgments

We thank FONDAZIONE ISI and the Association for the Promotion of the Scientific and Technological Development of Piedmont (ASP) for their financial support to this scientific project.

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Authors and Affiliations

  1. National Center for Scientific Research, Havana, Cuba

    Javier Aragón

  2. Center for Neuroscience, Havana, Cuba

    Ramón González

  3. Biomaterials Center, University of Havana, Havana, Cuba

    Gastón Fuentes

  4. Department of Advanced Science and Technology, University of Piemonte Orientale “A. Avogadro”, Alessandria, Italy

    Luca Palin, Gianluca Croce & Davide Viterbo

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  1. Javier Aragón
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  2. Ramón González
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  3. Gastón Fuentes
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  4. Luca Palin
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  5. Gianluca Croce
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  6. Davide Viterbo
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Correspondence to Javier Aragón.

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Aragón, J., González, R., Fuentes, G. et al. In vitro release kinetics and physical, chemical and mechanical characterization of a POVIAC ® /CaCO 3 /HAP-200 composite. J Mater Sci: Mater Med 23, 259–270 (2012). https://doi.org/10.1007/s10856-011-4514-1

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