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Poly(ε-caprolactone) and poly(d,l-lactic acid-co-glycolic acid) scaffolds used in bone tissue engineering prepared by melt compression–particulate leaching method

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Abstract

Porous bioresorbable polymers have been widely used as scaffolds in tissue engineering. Most of the bioresorbable scaffolds are aliphatic polyesters and the methods employed to prepare the porous morphology may vary. This work describes and evaluates the in vitro degradation of porous and dense scaffolds of poly(ε-caprolactone) (PCL) and poly(d,l-lactic acid-co-glycolic acid) (50/50) (PLGA50) prepared by particulate leaching-melt compression process. Biological evaluation was carried out using osteoblast cell cultures. The results showed an autocatalytic effect on the dense samples. Osteoblasts presented intermediate adhesion and the cell morphology on the surface of these materials was dispersed, which indicated a good interaction of the cells with the surface and the material.

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Acknowledgments

This work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq) (Grant 141582).

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Authors and Affiliations

  1. Department of Materials Engineering, Faculty of Mechanical Engineering, State University of Campinas (UNICAMP), Campinas, SP, Brazil

    Samuel H. Barbanti, Cecília A. C. Zavaglia & Eliana A. R. Duek

  2. Department of Physiological Sciences, Faculty of Biological Sciences, Pontificial Catholic University of São Paulo (PUCSP), Sorocaba, SP, Brazil

    Samuel H. Barbanti & Eliana A. R. Duek

  3. Natural and Human Sciences Center, Federal University of the ABC (UFABC), Santo André, SP, Brazil

    Arnaldo R. Santos Jr

Authors
  1. Samuel H. Barbanti
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  2. Arnaldo R. Santos Jr
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  3. Cecília A. C. Zavaglia
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  4. Eliana A. R. Duek
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Correspondence to Samuel H. Barbanti.

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Barbanti, S.H., Santos, A.R., Zavaglia, C.A.C. et al. Poly(ε-caprolactone) and poly(d,l-lactic acid-co-glycolic acid) scaffolds used in bone tissue engineering prepared by melt compression–particulate leaching method. J Mater Sci: Mater Med 22, 2377 (2011). https://doi.org/10.1007/s10856-011-4398-0

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  • DOI: https://doi.org/10.1007/s10856-011-4398-0

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