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Synthesis of nano-sized biphasic calcium phosphate ceramics with spherical shape by flame spray pyrolysis

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Abstract

Nanometer size biphasic calcium phosphate (BCP) powders with various Ca/P molar ratios satisfied with appropriate phase ratios of HA/β-TCP were prepared by high temperature flame spray pyrolysis process. The BCP powders had spherical shapes and narrow size distributions irrespective of the ratios of Ca/P. The mean size of the BCP powders measured from the TEM image was 38 nm. The composition ratio of Ca/P was controlled from 1.500 to 1.723 in the spray solution, and required phase ratios of HA/TCP are controlled systematically. The calcium dissolution of the pellets obtained from the BCP powders directly prepared by flame spray pyrolysis in buffer solution increased with the decrease of Ca/P ratios except with the Ca/P ratio of 1.713. The pellet surface with Ca/P ratio of 1.500, which consisted of β-TCP, was eroded dramatically for 7 days. On the other hand, the pellet surface with Ca/P ratio of 1.667 was stable and did not disintegrate after immersion in Tris–HCl buffer solution based on the SEM observation.

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Authors and Affiliations

  1. Department of Chemical Engineering, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Korea

    Jung Sang Cho, You Na Ko, Hye Young Koo & Yun Chan Kang

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  1. Jung Sang Cho
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  2. You Na Ko
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Correspondence to Yun Chan Kang.

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Cho, J.S., Ko, Y.N., Koo, H.Y. et al. Synthesis of nano-sized biphasic calcium phosphate ceramics with spherical shape by flame spray pyrolysis. J Mater Sci: Mater Med 21, 1143–1149 (2010). https://doi.org/10.1007/s10856-009-3980-1

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  • DOI: https://doi.org/10.1007/s10856-009-3980-1

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