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A new strategy for assembling multifunctional nanocomposites with iron oxide and amino-terminated PAMAM dendrimers

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Abstract

A new strategy for assembling multifunctional nanocomposites with magnetic particles and amino dendrimers was reported. In this strategy, the amino terminated PAMAM G5.0 and Fe3O4 NPs prepared by co-deposition method and further modified by aminosilane by two sol–gel processes were combined with the hydrophilic spacer of PEG dicarboxylate by amidation. The nanocomposites were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), atom force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, and hydrophilicity analysis. The results showed that the multifunctional nanocomposites were spherical with the mean diameter of 180 nm and exhibited good dispersion and hydrophilicity. The new strategy put forward here provides an effective route to functionalizing Fe3O4 NPs with various amino dendrimers for drug and gene delivery as well as biological detection.

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Acknowledgments

This work was supported by National Natural Science Foundation of China under Grant No. 50331030 and 50831006.

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Authors and Affiliations

  1. Shenyang National Laboratory for Materials Science, Institute of Metal Research and International Centre for Materials Physics, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang, 110016, Peoples’ Republic of China

    Ying Zhang, Fang Yang, Ya-Jing Zhang, Qi Yao, Tie-Yu Cui & Zhi-Dong Zhang

  2. College of Pharmaceutical Engineering, Shen Yang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Peoples’ Republic of China

    Ying Zhang, Jing-Ying Liu & Xiang Zhao

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  1. Ying Zhang
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Correspondence to Ying Zhang.

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Zhang, Y., Liu, JY., Yang, F. et al. A new strategy for assembling multifunctional nanocomposites with iron oxide and amino-terminated PAMAM dendrimers. J Mater Sci: Mater Med 20, 2433–2440 (2009). https://doi.org/10.1007/s10856-009-3808-z

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