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Phase assemblage study and cytocompatibility property of heat treated potassium magnesium phosphate–silicate ceramics

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Abstract

This article reports the study on a new generation bioactive ceramic, based on MgKPO4 (Magnesium Potassium Phosphate, abbreviated as MKP) for biomedical applications. A series of heat treatment experiments on the slip cast silica (SiO2) containing MKP ceramics were carried out at 900, 1,000 and 1,100°C for 4 h in air. The density of the slip cast ceramic increases to 2.5 gm/cm3 upon heat treatment at 900°C. However, no significant change in density is measured upon heat treatment to higher temperature of 1,000 and 1,100°C. On the basis of XRD results, the presence of K2MgSi5O12 and dehydrated MgKPO4 were confirmed and complementary information has also been obtained using FT-IR and Raman spectroscopy. In order to confirm the in vitro cytocompatibility property, the cell culture tests were carried out on selected samples and the results reveal good cell adhesion and spreading of L929 mouse fibroblast cells. MTT assay analysis with L929 cells confirmed non-cytotoxic behavior of MKP containing ceramics and the results are comparable with sintered HAp ceramics. It is expected that the newly developed MKP based materials could be a good substitute for hydroxyapatite (HAp or HA) based bioceramics.

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Acknowledgements

The authors gratefully acknowledge Dr. Rajeev Gupta for his co-operation in getting Raman spectroscopy results.

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Authors and Affiliations

  1. Laboratory for Advanced Ceramics, Department Materials and Metallurgical Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India

    Ravi Kumar, Sushma Kalmodia, Shekhar Nath & Bikramjit Basu

  2. Nuclear Engineering Division, Argonne National Laboratory, Argonne, IL, USA

    Dileep Singh

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  1. Ravi Kumar
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  2. Sushma Kalmodia
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  3. Shekhar Nath
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  4. Dileep Singh
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  5. Bikramjit Basu
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Correspondence to Bikramjit Basu.

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Kumar, R., Kalmodia, S., Nath, S. et al. Phase assemblage study and cytocompatibility property of heat treated potassium magnesium phosphate–silicate ceramics. J Mater Sci: Mater Med 20, 1689–1695 (2009). https://doi.org/10.1007/s10856-009-3725-1

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  • DOI: https://doi.org/10.1007/s10856-009-3725-1

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