Abstract
Hydroxyapatite (HAp)/gelatin (GEL) nanocomposite was prepared by the solution-precipitation process using Ca(OH)2 in water and aqueous solution of H3PO4 in GEL. Before the co precipitation process the GEL powders were dissolved in the aqueous phosphoric acid solution for the phosphorylation of GEL molecules. The chemical variation of the phosphorylated GEL macromolecules was investigated by using attenuated total reflection (ATR) measurement. The crystal growth of HAp became bigger with the long-time aging of the GEL molecules in the phosphoric acid solution, and it resulted from the reduction of length scale of the GEL molecules. The degree of the organic–inorganic interaction was decreased because of the degradation of the GEL macromolecules.
Similar content being viewed by others
References
M.C. Chang, W.H. Douglas, J. Tanaka, J. Mater. Sci. Mater. Med. 17, 387 (2006)
M.C. Chang, C.-C. Ko, W.H. Douglas, Biomaterials 24, 2853 (2003)
M.C. Chang, C.-C. Ko, W.H. Douglas, Biomaterials 24, 3087 (2003)
M.C. Chang, T. Ikoma, M. Kikuchi, J. Tanaka, J. Mater. Sci. Mater. Med. 13, 993 (2002)
R.A. Young, Clin. Orthopedics 113, 249 (1975)
S. Mann, G.A. Ozin, Nature 365, 499 (1996)
E. Dujardin, S. Mann, Adv. Eng. Mater. 4(7), 461 (2002)
A. Veis, The Macromolecular Chemistry of Gelatin (Academic Press, London, 1964)
A.G. Ward, A. Courts, The Science and Technology of Gelatin (Academic Press, London, 1977)
M.C. Chang, W.H. Douglas, J. Mater. Sci. Mater. Med. 18, 2045 (2007)
R.Z. Legeros, Monogr. Oral. Sci. Vol. 15, Calcium Phosphates in Oral Biology and Medicine (Kager, Basel, 1998), p. 1
M. Iijima, Monogr. Oral. Sci. Vol. 18, Octacalcium Phosphate, Formation of Octacalcium Phosphate In Vitro (Kager, Basel, 1998), pp. 16–49
L.C. Chow, J. Ceram. Soc. Jpn. 99, 954 (1991)
A.L. Boskey, A.S. Posner, J. Phys. Chem. 80, 40 (1976)
W.P. Inskee, J.C. Silvertooth, Geochim. Chosmochim. Acta 52, 1883 (1988)
R.J. Jakobsen, L.L. Brown, T.B. Hutson, D.J. Fink, A. Veis, Science 220, 1288 (1983)
E.P. Paschalis, E. Dicarlo, E. Betts, P. Shermann, R. Mendelsohn, A.L. Boskey, Calcif. Tissue Int. 59, 480 (1996)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chang, M.C. Organic–inorganic interaction between hydroxyapatite and gelatin with the aging of gelatin in aqueous phosphoric acid solution. J Mater Sci: Mater Med 19, 3411–3418 (2008). https://doi.org/10.1007/s10856-008-3488-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10856-008-3488-0