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Evaluation of an injectable, photopolymerizable three-dimensional scaffold based on d,l-lactide and ɛ-caprolactone in a tibial goat model

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Abstract

An in situ crosslinkable, biodegradable, methacrylate-encapped porous bone scaffold composed of d,l-lactide, ɛ-caprolactone, 1,6-hexanediol and poly(ortho-esters), in which crosslinkage is achieved by photoinitiators, was developed for bone tissue regeneration. Three different polymer mixtures (pure polymer and 30% bioactive glass or α-tricalcium phosphate added) were tested in a uni-cortical tibial defect model in eight goats. The polymers were randomly applicated in one of four (6.0 mm diameter) defects leaving a fourth defect unfilled. Biocompatibility and bone healing properties were evaluated by serial radiographies, histology and histomorphometry. The pure polymer clearly showed excellent biocompatibility and moderate osteoconductive properties. The addition of α-TCP increased the latter characteristics. This product offers potentials as a carrier for bone healing promoter substances.

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Acknowledgments

The authors thank Cindy De Baere, Bart De Pauw, Liliana Standaert and Lobke De Bels for technical assistance.

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Authors and Affiliations

  1. Department of Surgery and Anaesthesiology of Domestic Animals, Faculty of Veterinary Medicine Ghent, Salisburylaan 133, Merelbeke, 9820, Belgium

    Geert Vertenten, Lieven Vlaminck & Frank Gasthuys

  2. Polymer Material Research Group, Faculty of Sciences Ghent, Krijgslaan 281 (S4), Ghent, 9000, Belgium

    Tomasz Gorski & Etienne Schacht

  3. Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine Ghent, Salisburylaan 133, Merelbeke, 9820, Belgium

    Elke Schreurs

  4. Department of Morphology, Faculty of Veterinary Medicine Ghent, Salisburylaan 133, Merelbeke, 9820, Belgium

    Wim Van Den Broeck

  5. Department of Physiology and Biometry, Faculty of Veterinary Medicine Ghent, Salisburylaan 133, Merelbeke, 9820, Belgium

    Luc Duchateau

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  1. Geert Vertenten
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  2. Lieven Vlaminck
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  3. Tomasz Gorski
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Correspondence to Geert Vertenten.

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Vertenten, G., Vlaminck, L., Gorski, T. et al. Evaluation of an injectable, photopolymerizable three-dimensional scaffold based on d,l-lactide and ɛ-caprolactone in a tibial goat model. J Mater Sci: Mater Med 19, 2761–2769 (2008). https://doi.org/10.1007/s10856-008-3404-7

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  • DOI: https://doi.org/10.1007/s10856-008-3404-7

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