Skip to main content

Advertisement

SpringerLink
Log in

Synthesis and characterization of tricalcium phosphate with Zn and Mg based dopants

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

The purpose of this study is to prepare tricalcium phosphate (TCP) ceramic by dual dopants of magnesium (Mg) and zinc (Zn), and investigate the influence of dopants on the physical, mechanical and biological properties of TCP. TCP were synthesized with 1 wt% Mg, 0.3 wt% Zn and dual dopants using the precipitation process. Phase composition and microstructures were characterized. Mechanical properties and dissolution behavior in vitro were investigated. Human osteoblast cell culture was used to determine the influence of dopants on cell-materials interactions. XRD analysis indicated that Mg delayed phase transformation from β to α-TCP and pure β-TCP phase was obtained for Mg-doped TCP after sintered at 1250°C. Addition of Mg improved densification behavior of TCP. Compression strength also increased from 24.0 MPa to 77.2 MPa after doping with Mg and Zn. Furthermore, Mg additive reduced the solubility of TCP in vitro. Osteoblast culture studies indicated that the presence of Mg stabilized the cell-material interface and thus improved cell attachment and growth. Zn-doped TCP exhibited good bioactivity, which enhanced cell differentiation and alkaline phosphatase (ALP) expression. The highest cell proliferation and ALP expression were found on dual Mg and Zn doped TCP. The results indicate that Mg and Zn dopants play a significant role towards improving mechanical properties and cell-materials interactions of TCP. This work also demonstrates the potential for dual Mg and Zn doped TCP to be used in orthopedics and dentistry, which displays high mechanical strength, low resorption and improved cell-material interaction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. M. Hashizume, M. Yamaguchi, Mol. Cell. Biochem. 122, 59 (1993)

    Article  CAS  Google Scholar 

  2. S. Kishi, M. Yamaguchi, Biochem. Pharmacol. 48, 1225 (1994)

    Article  CAS  Google Scholar 

  3. B.S. Moonga, D.W. Dempster, J. Bone Miner. Res. 10, 453 (1995)

    Article  CAS  Google Scholar 

  4. H. Kawamura, A. Ito, S. Miyakawa, P. Layrolle, K. Ojima, H. Naito, N. Ichnose, T. Tateishi, J. Biomed. Mater. Res. 50, 184 (2000)

    Article  CAS  Google Scholar 

  5. T.H. Hyun, E. Barrett-Connor, D.B. Milne, Am. J. Clin. Nutr. 80, 715 (2004)

    CAS  Google Scholar 

  6. E. Fujii, M. Ohkubo, K. Tsuru, S. Hayakawa, A. Osaka, K. Kawabata, C. Bonhomme, F. Babonneau, Acta Biomaterialia. 2, 69 (2006)

    Article  Google Scholar 

  7. H. Storrie, S.I. Stupp, Biomaterials 26, 5492 (2005)

    Article  CAS  Google Scholar 

  8. Y. Sogo, A. Ito, K. Fukasawa, T. Sakurai, N. Ichinose, Mater. Sci. Tech. 20, 1079 (2004)

    Article  CAS  Google Scholar 

  9. A. Ito, M. Otsuka, H. Kawamura, M. Ikeuchi, H. Ohgushi, Y. Sogo, N. Ichinose, Curr. Appl. Phys. 5, 402 (2005)

    Article  Google Scholar 

  10. M. Otsuka, Y. Ohshita, S. Marunaka, Y. Matsuda, A. Ito, N. Ichinose, K. Otsuka, W.I. Higuchi, J. Biomed. Mater. Res. Part A 69, 552 (2004)

    Article  CAS  Google Scholar 

  11. H. Kawamura, A. Ito, T. Muramatsu, S. Miyakawa, N. Ochiai, T. Tateishi, J. Biomed. Mater. Res. Part A 65, 468 (2003)

    Article  CAS  Google Scholar 

  12. A. Ito, H. Kawamura, S. Miyakawa, P. Layrolle, N. Kanzaki, G. Treboux, K. Onuma, S.T. Sutsumi, J. Biomed. Mater. Res. 60, 224 (2002)

    Article  CAS  Google Scholar 

  13. A. Tas, S.B. Bhaduri, S. Jalota, Mater. Sci. Eng. C 27, 394 (2007)

    Article  CAS  Google Scholar 

  14. A. Bandyopadhyay, E.A. Withey, J. Moore, S. Bose, Mater. Sci. Eng. C 27, 14 (2007)

    Article  CAS  Google Scholar 

  15. M. Percival, Appl. Nutr. Sci. Rep. 5, 1 (1999)

    Google Scholar 

  16. K. Yoshida, N. Kondo, H. Kita, J. Am. Ceram. Soc. 88, 2315 (2005)

    Article  CAS  Google Scholar 

  17. B. Dickens, L.W. Schroeder, W.E. Brown, J. Sol. Stat. Chem. 10, 232 (1974)

    Article  CAS  Google Scholar 

  18. L.W. Schroeder, B. Dickens, W.E. Brown, J. Sol. Stat. Chem. 22, 253 (1977)

    Article  CAS  Google Scholar 

  19. R. Enderle, F. Gotz-Neunhoeffer, M. Gobbels, F.A. Muller, P. Greil, Biomaterials 26, 3379 (2005)

    Article  CAS  Google Scholar 

  20. F.H. Lin, C.H. Liao, K.S. Chen, J.S. Sun, C.P. Lin, Biomaterials 22, 2981 (2001)

    Article  CAS  Google Scholar 

  21. C. Tardei, F. Grigore, I. Pasuk, S. Stoleriu, J. Optoelectr. Adv. Mater. 8, 568 (2006)

    CAS  Google Scholar 

  22. A. Bandyopadhyay, S. Bernard, W.C. Xue, S. Bose, J. Am. Ceram. Soc. 89, 2675 (2006)

    Article  CAS  Google Scholar 

  23. S.R. Winn, G. Randolph, H. Uludag, S.C. Wonng, G.A. Hair, J.O. Hollinger, J. Bone Mineral. Res. 14, 1721 (1999)

    Article  CAS  Google Scholar 

  24. L. Calderin, X. Yin, M.J. Stott, M. Sayer, Biomaterials 23, 4155 (2002)

    Article  Google Scholar 

  25. J. Marchi, A.C.S. Dantas, P. Greil, J.C. Bressiani, A.H.A. Bressiani, F.A. Muller, Mater. Res. Bull. 42, 1040 (2007)

    Article  CAS  Google Scholar 

  26. J.C. Elliot, in Structure and Chemistry of the Apatites and Other Calcium Orthophosphates (Elsvier Science, Amsterdam, 1994)

  27. S.R. Radin, P. Ducheyne, J. Biomed. Mater. Res. 27, 35 (1993)

    Article  CAS  Google Scholar 

  28. S.R. Radin, P. Ducheyne, J. Biomed. Mater. Res. 28, 1303 (1994)

    Article  CAS  Google Scholar 

  29. H.S. Ryu, H.J. Youn, K.S. Hong, B.S. Chang, C.K. Lee, S.S. Chung, Biomaterials 23, 909 (2002)

    Article  CAS  Google Scholar 

  30. R. Famery, P.B. Richard, Ceram. Int. 20, 327 (1994)

    Article  CAS  Google Scholar 

  31. X. Wei, M. Akinc, in Advances in Bioceramics and Biocomposites: Ceramic Engineering and Science Proceedings, vol 26, ed. by D. Zhu, W. Kriven (2005), pp 129

Download references

Acknowledgements

The authors gratefully acknowledge the financial support from National Science Foundation (Grant # 0134476) and the Office of Naval Research (Grant Nos: N00014-1-04-0644 and N00014-1-05-0583).

Author information

Authors and Affiliations

  1. W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, USA

    Weichang Xue, Kelli Dahlquist, Ashis Banerjee, Amit Bandyopadhyay & Susmita Bose

Authors
  1. Weichang Xue
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kelli Dahlquist
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ashis Banerjee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Amit Bandyopadhyay
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Susmita Bose
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Susmita Bose.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Xue, W., Dahlquist, K., Banerjee, A. et al. Synthesis and characterization of tricalcium phosphate with Zn and Mg based dopants. J Mater Sci: Mater Med 19, 2669–2677 (2008). https://doi.org/10.1007/s10856-008-3395-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-008-3395-4

Keywords

Search

Navigation