Abstract
Hollow Microspheres of hydroxyapatite-polymer composite can be used as carriers in drug delivery and fillers in tissue engineering. Based on the concept of soft chemistry, a battery of technique is available in the literature to synthesize hollow microspheres, however, an economically viable synthesis route, having good control over the microarchitect and easy to be scaled up, is yet to be developed. Polymer matrix mediated synthesis of inorganic nanoparticles is known to synthesize nanoparticles with controlled morphology and dimensions. It is termed as biomimetic synthesis. Integrating the biomimetic synthesis of nano-particles and spray drying techniques, a novel process of producing hydroxyapatite-polymer composite hollow microspheres is briefly discussed here.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
H. W. KIM, H. E. KIM and V. SALIH, Biomaterial 26 (2005) 5221
H. W. KIM, J. C. KNOWELS and H. E. KIM, J. Biomed. Mater. Res. 72A (2005) 136
T. KATSUMURA, T. KOSHINO and T. SAITO, Biomaterial 19 (1998) 1839
M. SIVAKUMAR and T. P. RAO, Biomaterial 23, 3175 (2002)
N. K. VARDE and D. W. PACK, Expert Opin. Biol. Th. 4 (2004) 35
A. J. WANG, Y. P. LU and R. X. SUN, Mater. Sci. Engg. A. 460–461 (2007) 1
F. NAGATA, T. MIYAJIMA and Y. YOKOGAWA, J. Eur. Cer. Soc. 26 (2006) 533
Q. Q. QIU, P. DUCHEYNE and P. S. AYYASWAMY, Ann. NY Acad. Sci. 974 (2002) 556
J. G. ZHANG, S. Q. XU and E. KUMACHEVA, J. Am. Chem. Soc. 126 (2004) 7908
A. SINHA, S. NAYAR, A. AGRAWAL, V. RAO and P. RAMACHANDRA RAO, Indian patent on “A process for preparatin of nanosized hydroxyapatite by a biomimetic route” Patent Number: 192392 Dated 28 Feb. 2005
A. SINHA, S. K. DAS, V. RAO and P. RAMACHANDRARAO, Scripta Met. Mater. 44 (2001) 1933
A. SINHA, S. KUMAR DAS, V. RAO and P. RAMACHANDRARAO, J. Mater. Res. 46 (2001) 1846
A. SINHA, S. NAYAR, A. AGRAWAL, D. BHATTACHARYA and P. RAMACHANDRARAO, J. Am. Cer. Soc. 86 (2003) 357
S. NAYAR and A. SINHA, Coll. Surf. B. 35 (2004) 29
B. JURGEN, B. JAN and K. ROLF, Chem. Eng. Technol. 27 (2004) 829
P. LUO and T. G. NIEH, Mater. Sci. Eng. C3 (1995) 75
R. X. SUN, M. S. LI and Y. P. LU, Mater. Rev. 19 (2005) 10
A. M. GOULA and K. G. ADAMOPOULOS, J. Food Eng. 66 (2005) 35
M. G. ATHANASIA and G. A. KOUSTANTINOS, J. Food Eng. 66 (2005) 25
I. FERRY, G. LEON and O. KIKUO, J. Colloid Interf. Sci. 265 (2003) 296
V. M. RUSU, N. CHUEN-HOW, M. WILKE, T. BRIGTTE, F. PETER and M. G. PETER, Biomaterial 26, 5414 (2005)
E. LANDI, A. TAMPIERI, G. CELOTTI and S. SPRIO, J. Eur. Ceram. Soc. 20 (2000) 2377
N. DEGIRMENBASI, D. M. KALYON and E. BIRINCI, Coll. Surf. B 48 (2006) 42
Acknowledgements
Author (AS) acknowledges the financial support received from Department of Biotechnology (DBT) New Delhi for Biomimetics project.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sinha, A., Mishra, T. & Ravishankar, N. Polymer assisted hydroxyapatite microspheres suitable for biomedical application. J Mater Sci: Mater Med 19, 2009–2013 (2008). https://doi.org/10.1007/s10856-007-3286-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10856-007-3286-0