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In vitro studies of novel CaO–SiO2–MgO system composite bioceramics

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Abstract

In this study, a series of CaO–SiO2–MgO composites with different β-CaSiO3 (CS)/Mg2SiO4 (M2S) composite ratios were prepared to produce new bioactive and biodegradable biomaterials for potential bone repair. The mechanical properties of CS–M2S composites increased steadily with the increase of M2S ratios in composites. Dissolution tests in Tris–HCl buffer solution showed obvious differences with different CS initial composite ratio in composites. The dissolution rate increased with the increase of CS composite ratio, which suggested that the solubility of composites could be tailored by adjusting the initial CS/M2S composite ratio. Formation of bone-like apatite on a range of CS–M2S composites with CS weight percentage ranging from 0 to 100 has been investigated in simulated body fluid (SBF). The presence of bone-like apatite layer on the composite surface after soaking in SBF was demonstrated by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM). The results showed that the apatite formation ability of the CS–M2S composite with 70% CS was detected after 10 days immersion. In vitro cell experiments showed that the 50 and 70% CS composites supported greater osteoblast-like cell proliferation as compared with pure M2S (p < 0.05). The results of this study suggested that the CS–M2S composites with 50 and 70% initial CS composite amount might be more suitable for preparation of bone repair materials.

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Acknowledgements

This work is supported by the National Basic Science Research Program of China (973 Program) (Grant No. 2005CB522700) and Science and Technology Commission of Shanghai Municipality (Grant No. 02JC14009).

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Authors and Affiliations

  1. Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, 201620, China

    Siyu Ni

  2. Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China

    Siyu Ni & Jiang Chang

  3. Department of Biomaterials, Goldman School of Dental Medicine, Boston University, Boston, MA, 02118, USA

    Lee Chou

Authors
  1. Siyu Ni
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  2. Jiang Chang
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  3. Lee Chou
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Correspondence to Siyu Ni.

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Ni, S., Chang, J. & Chou, L. In vitro studies of novel CaO–SiO2–MgO system composite bioceramics. J Mater Sci: Mater Med 19, 359–367 (2008). https://doi.org/10.1007/s10856-007-3186-3

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  • DOI: https://doi.org/10.1007/s10856-007-3186-3

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