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Synthesis and properties of O-carboxymethyl chitosan/methoxy poly(ethylene glycol) graft copolymers

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Abstract

O-carboxymethyl chitosan/methoxy poly(ethylene glycol) graft copolymers (OCMCS-g-MPEGs) with different degrees of substitution (DS) were synthesized by reductive N-alkylation of chitosan with poly(ethylene glycol) aldehyde. The properties of OCMCS-g-MPEGs, including the solubility, structure, hydrodynamic behaviors, isoelectric point (IEP) and interaction with water-soluble chitosan, were investigated. As a PEGylated polyampholyte, OCMCS-g-MPEGs can resolve in water over all pH range and the pH value at IEP (pHIEP) decreases when DS increases. The hydrodynamic behaviors of OCMCS-g-MPEGs in deionized H2O are markedly affected by DS and pHIEP in the experiment concentration range. The particle size of the complexes of OCMCS-g-MPEGs with water-soluble chitosan is strongly affected by the concentration of water-soluble chitosan and the pH value.

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Acknowledgements

This work had been supported by Program for New Century Excellent Talents in University of China and Programme of Introducing Talents of Discipline to Universities (No: B06006).

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  1. Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, P.R. China

    An-Jie Dong, Meng-Huang Feng, Hai-Ying Qi, Shan-Shan Li & Lian-Dong Deng

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Dong, AJ., Feng, MH., Qi, HY. et al. Synthesis and properties of O-carboxymethyl chitosan/methoxy poly(ethylene glycol) graft copolymers. J Mater Sci: Mater Med 19, 869–876 (2008). https://doi.org/10.1007/s10856-007-3183-6

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