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Rheological behavior of anionic collagen injectable gels in the presence of rhamsan for plastic surgery applications

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Abstract

The present paper describes the rheological properties of anionic collagen gels and anionic collagen:rhamsan composites gels in the concentration of 0.7, 4 and 6%, estimated to be used as injectable biomaterials for plastic reconstruction. Rheological studies of these gels showed that independently of pH, composition and concentration the viscoelastic behavior was dependent on the frequency, with the storage modulus always greater than the loss modulus (G′ > G″ and δ < 45°). Creep experiments showed that anionic collagen:rhamsan composites equilibrated at pH 7.4 were less elastic and more susceptible to deformation in comparison to gels equilibrated at pH 3.5. Flow experiments indicated that the force needed for the extrusion of anionic collagen:rhamsan composites, in comparison to anionic collagen, was significantly smaller and with a smoother flow, suggesting the association with rhamsan may be a good alternative in the replacement of glutaraldehyde to stabilize the microfibril assembly of commercial collagen gel preparations. Finally, on the basis of dynamic viscosity profiles found for different preparations, some of these composites are potential candidates to be utilized in laryngology.

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Acknowledgment

The authors would like to acknowledge Ézer Biazin and Glauco D. Broch for their technical assistance, FAPESP for the financial support (contract n° 99/04806-0 and 01/06165-4) given to this research and Angela Cristina P. Giampedro for the text revision. Dr. Márcio de Paula is grant holder RHAE-CNPq, modality DTI, in RHAE of BIOMEDICAL PROLINE LTDA project coordinated by Dr. Gilberto Goissis.

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Authors and Affiliations

  1. Laboratório de Bioquímica/Biomateriais. Departamento de Química e Física Molecular do Instituto de Química de São Carlos, Universidade de São Paulo, Av. do Trabalhador Sãocarlense, 400 São Carlos, Sao Paulo, CEP 13560-970, SP, Brasil

    Márcio de Paula, Gilberto Goissis & Virginia Conceição Amaro Martins

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  1. Márcio de Paula
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  2. Gilberto Goissis
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  3. Virginia Conceição Amaro Martins
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Correspondence to Márcio de Paula.

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de Paula, M., Goissis, G. & Martins, V.C.A. Rheological behavior of anionic collagen injectable gels in the presence of rhamsan for plastic surgery applications. J Mater Sci: Mater Med 18, 1683–1690 (2007). https://doi.org/10.1007/s10856-007-3058-x

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  • DOI: https://doi.org/10.1007/s10856-007-3058-x

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